Danusertib

Product Name: Danusertib
CAS No.: 827318-97-8
Chemical Name: Danusertib
Synonyms: CS-1856;CS-1969;PHA-739358;danusertib;Unii-m3X659D0fy;Danusertib USP/EP/BP;Danusertib(PHA-739358);PHA-739358(Danusertib);PHA-739358 Danusertib PHA739358;PHA-739358; PHA739358; PHA 739358
CBNumber: CB81518500
Molecular Formula: C26H30N6O3
Formula Weight: 474.55
MOL File: 827318-97-8.mol

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Danusertib Property

Melting point:: >145°C (dec.)
Boiling point:: 664.1±55.0 °C(Predicted)
Density: 1.322
storage temp.: Refrigerator
solubility: DMSO (Slightly), Methanol (Slightly)
form: Solid
pka: 13.70±0.20(Predicted)
color: Pale Beige

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 18387
Product name: Danusertib
Purity: ≥95%
Packaging: 1mg
Price: $44
Updated: 2024/03/01

Cayman Chemical

Product number: 18387
Product name: Danusertib
Purity: ≥95%
Packaging: 5mg
Price: $193
Updated: 2024/03/01

Cayman Chemical

Product number: 18387
Product name: Danusertib
Purity: ≥95%
Packaging: 10mg
Price: $341
Updated: 2024/03/01

Cayman Chemical

Product number: 18387
Product name: Danusertib
Purity: ≥95%
Packaging: 50mg
Price: $1148
Updated: 2024/03/01

Usbiological

Product number: 474091
Product name: Danusertib
Packaging: 100mg
Price: $1932
Updated: 2021/12/16

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Danusertib Chemical Properties,Usage,Production

Uses

An Aurora kinase inhibitor, used to treat patients with chromic myeloid leukemia. It is a COVID19-related research product.

Uses

Danusertib is an Aurora kinase inhibitor, used to treat patients with chromic myeloid leukemia.

Definition

ChEBI: N-[5-[(2R)-2-methoxy-1-oxo-2-phenylethyl]-4,6-dihydro-1H-pyrrolo[3,4-c]pyrazol-3-yl]-4-(4-methyl-1-piperazinyl)benzamide is a member of piperazines.

Biological Activity

danusertib (previously known as pha-739358), a 3-aminopyrazole derivative identified during the development of the pyrrolopyrazole sub-series, is a potent small-molecule inhibitor of aurora kinases family members with a dominant inhibition for aurora b kinase (abk). this pan-aurora kinases inhibitor is also able to inhibit several tyrosine kinases, including t315i mutant, ret, trk-a and fibroblast growth factor receptor-1 (fgfr-1), which are involved in multiple malignancies, such as chronic myelogenous leukemia (cml), acute lymphoblastic leukemia (all), thyroid prostate and breast carcinoma. thus, in many previous studies, danusertib exhibits remarkable antitumor activity in a number of different xengorafts, spontaneous, and transgenic animal tumor models with a favorable pharmacokinetic and safety profile.carpinelli p, ceruti r, giorgini ml, cappella p, gianellini l, croci v, degrassi a, texido g, rocchetti m, vianello p, rusconi l, storici p, zugnoni p, arrigoni c, soncini c, alli c, patton v, marsiglio a, ballinari d, pesenti e, fancelli d, moll j. pha-739358, a potent inhibitor of aurora kinases with a selecyive target inhibiton profile relevant to cancer. mol cancer ther 2007; 6(12 pt 1): 3158-3168

target

Aurora A/B/C

Danusertib Preparation Products And Raw materials

Raw materials

Preparation Products

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Danusertib Suppliers

Canada 1 China 93 Germany 1 India 2 United Kingdom 2 United States 17 Global 116

AdooQ BioScience, LLC

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827318-97-8, DanusertibRelated Search:

N-ACETYL-L-TYROSINE ETHYL ESTER Anisole Pralmorelin 2-Methoxyethanol (Trifluoromethoxy)benzene 4-Methoxyphenylacetone p-Anisaldehyde 4-Methoxybenzylchloride 4'-Methoxyacetophenone p-Anisidine Pyrrolidine PHA-793887 Tadalafil Dasatinib Danusertib Methoxy

PHA-739358

(R)-N-(5-(2-methoxy-2-phenylacetyl)-1,4,5,6-tetrahydropyrrolo[3,4-c]pyrazol-3-yl)-4-(4-methylpiperazin-1-yl)benzamide,PHA739358

Benzamide, 4-(4-methyl-1-piperazinyl)-N-(1,4,5,6-tetrahydro-5-((2R)- methoxyphenylacetyl)pyrrolo(3,4-C)pyrazol-3-yl)-

Unii-m3X659D0fy

Danusertib(PHA-739358)

danusertib

N-[5-((2R)-2-Methoxy-2-phenylethanoyl)-1,4,5,6-tetrahydropyrrolo[3,4-c]pyrazol-3-yl]-4-(4-methylpiperazin-1-yl)benzamide

PHA-739358(Danusertib)

4-(4-Methyl-1-piperazinyl)-N-[1,4,5,6-tetrahydro-5-[(2R)-2-Methoxy-2-phenylacetyl]pyrrolo[3,4-c]pyrazol-3-yl]benzaMide

N-{5-[(2R)-2-Methoxy-2-phenylacetyl]-1H,4H,5H,6H-pyrrolo[3,4-c]pyrazol-3-yl}-4-(4-Methylpiperazin-1-yl)benzaMide

(R)-N-(5-(2-Methoxy-2-phenylacetyl)-1,4,5,6-tetrahydropyrrolo[3,4-c]pyrazol-3-yl)-4-(4-Methylpiperazin-1-yl)benz

(R)-N-(5-(2-methoxy-2-phenylacetyl)-1,4,5,6-tetrahydropyrrolo[3,4-c]pyrazol-3-yl)-4-(4-methylpiperazin-1-yl)benzamide

Danusertib N-[5-((2R)-2-Methoxy-2-phenylethanoyl)-1,4,5,6-tetrahydropyrrolo[3,4-c]pyrazol-3-yl]-4-(4-methylpiperazin-1-yl)benzamide

PHA-739358; PHA739358; PHA 739358

(R)-N-(5-(2-Methoxy-2-phenylacetyl)-1,4,5,6-tetrahydropyrrolo-[3,4-c]pyrazol-3-yl)-4-(4-methyl

N-[5-((2R)-2-Methoxy-2-phenylethanoyl)-1,4,5,6-tetrahydropyrrolo[3,4-c]pyrazol-3-yl]-4-(4-methylpiperazin-1-yl)benzamide Danusertib (PHA-739358)

CS-1856

CS-1969

Benzamide, 4-(4-methyl-1-piperazinyl)-N-[1,4,5,6-tetrahydro-5-[(2R)-2-methoxy-2-phenylacetyl]pyrrolo[3,4-c]pyrazol-3-yl]-

Danusertib USP/EP/BP

N-[5-[(2R)-2-methoxy-2-phenylacetyl]-4,6-dihydro-1H-pyrrolo[3,4-c]pyrazol-3-yl]-4-(4-methylpiperazin-1-yl)benzamide

PHA-739358 Danusertib PHA739358

827318-97-8

C26H30N6O

Inhibitor

Apis

Inhibitors

Intermediates & Fine Chemicals

Pharmaceuticals