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Abacavir-d4

Product Name
Abacavir-d4
CAS No.
1260619-56-4
Chemical Name
Abacavir-d4
Synonyms
ABC-d4;Ziagen-d4;1592U89-d4;Abacavir-d4;Abacavir D4 HCl;Abacavir-d4;(1S,4R)-4-[2-AMino-6-(cyclopropylaMino-d4)-9H-purin-9-yl]-2-cyclopentene-1-Methanol;(1S,4R)-4-[2-Amino-6-[(cyclopropyl-d4)amino]-9H-purin-9-yl]-2-cycpentene-1-methanol;(1S-cis)-4-[2-AMino-6-(cyclopropylaMino-d4)-9H-purin-9-yl]-2-cyclopentene- 1-Methanol;((1S,4R)-4-(2-amino-6-((cyclopropyl-2,2,3,3-d4)amino)-9H-purin-9-yl)cyclopent-2-en-1-yl)methanol
CBNumber
CB81565155
Molecular Formula
C14H18N6O
Formula Weight
286.33232
MOL File
1260619-56-4.mol
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Abacavir-d4 Property

Melting point:
222-225°C
storage temp. 
-20°C Freezer
solubility 
DMSO (Slightly), Methanol (Slightly)
form 
Solid
color 
Off-White to Light Beige
Stability:
Very Hygroscopic
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
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N-Bromosuccinimide Price

Cayman Chemical
Product number
30076
Product name
Abacavir-d4
Packaging
500μg
Price
$117
Updated
2024/03/01
Cayman Chemical
Product number
30076
Product name
Abacavir-d4
Packaging
1mg
Price
$222
Updated
2024/03/01
Usbiological
Product number
001009
Product name
Abacavir-d4
Packaging
1mg
Price
$496
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
RDL0006640
Product name
ABACAVIR-D4
Purity
95.00%
Packaging
1MG
Price
$779.63
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
RDL0006640
Product name
ABACAVIR-D4
Purity
95.00%
Packaging
10MG
Price
$2194.5
Updated
2021/12/16
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Abacavir-d4 Chemical Properties,Usage,Production

Description

Abacavir-d4 is intended for use as an internal standard for the quantification of abacavir by GC- or LC-MS. Abacavir is a nucleoside analog and an inhibitor of HIV-1 reverse transcriptase (Ki = 2.1 μM for the wild-type enzyme). It inhibits replication of a variety of HIV-1 and HIV-2 strains, including strains resistant to 3''-azido-3''-deoxythymidine (zidovudine; ) or 2'',3''-dideoxyinosine (didanosine; ), in HeLa cells stably expressing CD4 (IC50s = 5.8-21 μM). Abacavir inhibits replication of eight HIV-1 clinical isolates in phytohemagglutinin-stimulated isolated human peripheral blood lymphocytes with a mean IC50 value of 0.26 μM. It inhibits hepatitis B virus (HBV) DNA synthesis in HepG2 cells (IC50 = 7 μM) and is also active against human cytomegalovirus (CMV) strain AD169 and the Petaluma strain of feline immunodeficiency virus (FIV) in plaque reduction assays (IC50s = 32 and 0.4 μM, respectively). Formulations containing abacavir have been used in the treatment of HIV infection.

Chemical Properties

White Solid

Uses

A labelled nucleoside reverse transcriptase inhibitor (NRTI)

Uses

Abacavir-d4 is deuterium labeled Abacavir (A104990). Abacavir is a carbocyclic 2''-deoxyguanosine nucleoside reverse transcriptase inhibitor and an anti-HIV drug used to treat HIV infection (1). Intracellular enzymes convert Abacavir to its active form, carbovir-triphosphate (CBV-TP), which then selectively inhibits HIV reverse transcriptase by incorporating into viral DNA (2). Abacavir is metabolized in the liver by uridine diphosphate glucuronyltransferase and alcohol dehydrogenase resulting in inactive glucuronide and carboxylate metabolites, respectively.

Abacavir-d4 Preparation Products And Raw materials

Raw materials

Preparation Products

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Abacavir-d4 Suppliers

Canada 2 China 21 France 1 India 4 United States 5 Global 33
Toronto Research Chemicals
Tel
--
Fax
--
Email
info@trc-canada.com
Country
Canada
ProdList
6038
Advantage
71
TLC PharmaChem Inc.
Tel
--
Fax
--
Email
research@tlcpharmachem.com
Country
Canada
ProdList
921
Advantage
60

1260619-56-4, Abacavir-d4Related Search:

Abacavir (1S–4R)-4-(2-amino-6-chloro-9H-purin-9-yl)-2-cyclopentene-1-methanol hydrochloride Abacavir Abacavir 5’-Phosphate 2-Cyclopentene-1-methanol, 4-[2-amino-6-(cyclopropylamino)-9H-purin-9-yl]-, (1R-cis)- Abacavir Abacavir Carboxylate (1R,3S)-3-[2-AMino-6-(cyclopropylaMino)-9H-purin-9-yl]cyclopentaneMethanol 2-Amino-6-cyclopropylamino-9H-purine Abacavir 5'-Glucuronide Abacavir (1S,4R)-(4-Aminocyclopent-2-enyl)methanol hydrochloride Abacavir Related CoMpound D trans-Abacavir Hydrochloride Abacavir sulfate 6-aminocarbovir Abacavir Impurity 1 Abacavir Impurity 6

  • (1S,4R)-4-[2-Amino-6-[(cyclopropyl-d4)amino]-9H-purin-9-yl]-2-cycpentene-1-methanol
  • Abacavir-d4
  • Ziagen-d4
  • Abacavir D4 HCl
  • (1S,4R)-4-[2-AMino-6-(cyclopropylaMino-d4)-9H-purin-9-yl]-2-cyclopentene-1-Methanol
  • (1S-cis)-4-[2-AMino-6-(cyclopropylaMino-d4)-9H-purin-9-yl]-2-cyclopentene- 1-Methanol
  • 1592U89-d4
  • ABC-d4
  • Abacavir-d<sub>4</sub>
  • ((1S,4R)-4-(2-amino-6-((cyclopropyl-2,2,3,3-d4)amino)-9H-purin-9-yl)cyclopent-2-en-1-yl)methanol
  • 1260619-56-4
  • C14H14N6OD4
  • C14H14D4N6O
  • Bases & Related Reagents
  • Intermediates & Fine Chemicals
  • Isotope Labeled Compounds
  • Nucleotides
  • Isotope Labelled Compounds
  • Pharmaceuticals