Abacavir-d4

Product Name: Abacavir-d4
CAS No.: 1260619-56-4
Chemical Name: Abacavir-d4
Synonyms: ABC-d4;Ziagen-d4;1592U89-d4;Abacavir-d4;Abacavir D4 HCl;Abacavir-d4;(1S,4R)-4-[2-AMino-6-(cyclopropylaMino-d4)-9H-purin-9-yl]-2-cyclopentene-1-Methanol;(1S,4R)-4-[2-Amino-6-[(cyclopropyl-d4)amino]-9H-purin-9-yl]-2-cycpentene-1-methanol;(1S-cis)-4-[2-AMino-6-(cyclopropylaMino-d4)-9H-purin-9-yl]-2-cyclopentene- 1-Methanol;((1S,4R)-4-(2-amino-6-((cyclopropyl-2,2,3,3-d4)amino)-9H-purin-9-yl)cyclopent-2-en-1-yl)methanol
CBNumber: CB81565155
Molecular Formula: C14H18N6O
Formula Weight: 286.33232
MOL File: 1260619-56-4.mol

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Abacavir-d4 Property

Melting point:: 222-225°C
storage temp.: -20°C Freezer
solubility: DMSO (Slightly), Methanol (Slightly)
form: Solid
color: Off-White to Light Beige
Stability:: Very Hygroscopic

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word: Warning

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 30076
Product name: Abacavir-d4
Packaging: 500μg
Price: $117
Updated: 2024/03/01

Cayman Chemical

Product number: 30076
Product name: Abacavir-d4
Packaging: 1mg
Price: $222
Updated: 2024/03/01

Usbiological

Product number: 001009
Product name: Abacavir-d4
Packaging: 1mg
Price: $496
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: RDL0006640
Product name: ABACAVIR-D4
Purity: 95.00%
Packaging: 1MG
Price: $779.63
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: RDL0006640
Product name: ABACAVIR-D4
Purity: 95.00%
Packaging: 10MG
Price: $2194.5
Updated: 2021/12/16

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Abacavir-d4 Chemical Properties,Usage,Production

Description

Abacavir-d₄ is intended for use as an internal standard for the quantification of abacavir by GC- or LC-MS. Abacavir is a nucleoside analog and an inhibitor of HIV-1 reverse transcriptase (K_i = 2.1 μM for the wild-type enzyme). It inhibits replication of a variety of HIV-1 and HIV-2 strains, including strains resistant to 3''-azido-3''-deoxythymidine (zidovudine; ) or 2'',3''-dideoxyinosine (didanosine; ), in HeLa cells stably expressing CD4 (IC₅₀s = 5.8-21 μM). Abacavir inhibits replication of eight HIV-1 clinical isolates in phytohemagglutinin-stimulated isolated human peripheral blood lymphocytes with a mean IC₅₀ value of 0.26 μM. It inhibits hepatitis B virus (HBV) DNA synthesis in HepG2 cells (IC₅₀ = 7 μM) and is also active against human cytomegalovirus (CMV) strain AD169 and the Petaluma strain of feline immunodeficiency virus (FIV) in plaque reduction assays (IC₅₀s = 32 and 0.4 μM, respectively). Formulations containing abacavir have been used in the treatment of HIV infection.

Chemical Properties

White Solid

Uses

A labelled nucleoside reverse transcriptase inhibitor (NRTI)

Uses

Abacavir-d4 is deuterium labeled Abacavir (A104990). Abacavir is a carbocyclic 2''-deoxyguanosine nucleoside reverse transcriptase inhibitor and an anti-HIV drug used to treat HIV infection (1). Intracellular enzymes convert Abacavir to its active form, carbovir-triphosphate (CBV-TP), which then selectively inhibits HIV reverse transcriptase by incorporating into viral DNA (2). Abacavir is metabolized in the liver by uridine diphosphate glucuronyltransferase and alcohol dehydrogenase resulting in inactive glucuronide and carboxylate metabolites, respectively.

Abacavir-d4 Preparation Products And Raw materials

Raw materials

Preparation Products

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Abacavir-d4 Suppliers

Canada 2 China 21 France 1 India 4 United States 5 Global 33

Chemsky（shanghai）International Co.,Ltd.

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Shenzhen SUNGENING Bio-Medical Co., Ltd.

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Nanjing Shizhou Biology Technology Co.,Ltd

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TargetMol Chemicals Inc.

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Beijing Boaolong Immunology Technology Co., Ltd.

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1260619-56-4, Abacavir-d4Related Search:

Abacavir (1S–4R)-4-(2-amino-6-chloro-9H-purin-9-yl)-2-cyclopentene-1-methanol hydrochloride Abacavir Abacavir 5’-Phosphate 2-Cyclopentene-1-methanol, 4-[2-amino-6-(cyclopropylamino)-9H-purin-9-yl]-, (1R-cis)- Abacavir Abacavir Carboxylate (1R,3S)-3-[2-AMino-6-(cyclopropylaMino)-9H-purin-9-yl]cyclopentaneMethanol 2-Amino-6-cyclopropylamino-9H-purine Abacavir 5'-Glucuronide Abacavir (1S,4R)-(4-Aminocyclopent-2-enyl)methanol hydrochloride Abacavir Related CoMpound D trans-Abacavir Hydrochloride Abacavir sulfate 6-aminocarbovir Abacavir Impurity 1 Abacavir Impurity 6

(1S,4R)-4-[2-Amino-6-[(cyclopropyl-d4)amino]-9H-purin-9-yl]-2-cycpentene-1-methanol

Abacavir-d4

Ziagen-d4

Abacavir D4 HCl

(1S,4R)-4-[2-AMino-6-(cyclopropylaMino-d4)-9H-purin-9-yl]-2-cyclopentene-1-Methanol

(1S-cis)-4-[2-AMino-6-(cyclopropylaMino-d4)-9H-purin-9-yl]-2-cyclopentene- 1-Methanol

1592U89-d4

ABC-d4

Abacavir-d<sub>4</sub>

((1S,4R)-4-(2-amino-6-((cyclopropyl-2,2,3,3-d4)amino)-9H-purin-9-yl)cyclopent-2-en-1-yl)methanol

1260619-56-4

C14H14N6OD4

C14H14D4N6O

Bases & Related Reagents

Intermediates & Fine Chemicals

Isotope Labeled Compounds

Nucleotides

Isotope Labelled Compounds

Pharmaceuticals