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Omeprazole

Product Name
Omeprazole
CAS No.
73590-58-6
Chemical Name
Omeprazole
Synonyms
OMEPRAZOL;PRILOSEC;LOSEC;OMEPRAZOLE BASE;5-METHOXY-2[(4-METHOXY-3,5-DIMETHYL-2-PYRIDYL)METHYLSULFINYL]-1H-BENZIMIDAZOLE;miol;elgam;zimor;ANTRA;aulcer
CBNumber
CB8160492
Molecular Formula
C17H19N3O3S
Formula Weight
345.42
MOL File
73590-58-6.mol
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Omeprazole Property

Melting point:
156°C
Boiling point:
600.0±60.0 °C(Predicted)
Density 
1.332 g/cm3
Flash point:
9℃
storage temp. 
2-8°C
solubility 
H2O: 0.5 mg/mL
form 
solid
pka
pKa 4.14/8.9(H2O,t =25,I=0.025) (Uncertain)
color 
white
Water Solubility 
Soluble in water (0.5 mg/ml), DMSO (25 mg/ml), and ethanol (4.5 mg/ml).
Merck 
14,6845
BCS Class
2
Stability:
Stable, but hygroscopic and photosensitive. Incompatible with strong oxidizing agents. Store in the dark.
InChIKey
SUBDBMMJDZJVOS-UHFFFAOYSA-N
CAS DataBase Reference
73590-58-6(CAS DataBase Reference)
EPA Substance Registry System
1H-Benzimidazole, 6-methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]sulfinyl]- (73590-58-6)
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Safety

Hazard Codes 
Xi,T,F
Risk Statements 
36/37/38-39/23/24/25-23/24/25-11
Safety Statements 
26-36-37/39-45-36/37-16-7
RIDADR 
UN1230 - class 3 - PG 2 - Methanol, solution
WGK Germany 
2
RTECS 
DD9087000
HS Code 
29333990
Hazardous Substances Data
73590-58-6(Hazardous Substances Data)
Toxicity
LD50 in mice, rats (g/kg): 0.08, >0.05 i.v.; >4, >4 orally (Ekman)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H225Highly Flammable liquid and vapour

H303May be harmfulif swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

H370Causes damage to organs

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P311Call a POISON CENTER or doctor/physician.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
19329
Product name
Omeprazole
Purity
analytical standard
Packaging
50mg
Price
$83.8
Updated
2024/03/01
Sigma-Aldrich
Product number
1478505
Product name
Omeprazole
Purity
United States Pharmacopeia (USP) Reference Standard
Packaging
200mg
Price
$436
Updated
2024/03/01
Sigma-Aldrich
Product number
BP765
Product name
Omeprazole
Purity
British Pharmacopoeia (BP) Reference Standard
Packaging
100MG
Price
$242
Updated
2023/06/20
Sigma-Aldrich
Product number
O-021
Product name
Omeprazole solution
Purity
1.0?mg/mL in methanol, ampule of 1?mL, certified reference material, Cerilliant?
Packaging
1mL
Price
$55.4
Updated
2022/05/15
TCI Chemical
Product number
O0359
Product name
Omeprazole
Purity
>98.0%(HPLC)(T)
Packaging
5g
Price
$104
Updated
2024/03/01
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Omeprazole Chemical Properties,Usage,Production

Description

Omeprazole is a potent gastric antisecretory agent with selective inhibitory effect on the H+,K+-ATPase proton pump. It is highly effective in the treatment of duodenal ulcer and Zollinger-Ellison syndrome, and is reportedly superior to ranitidine in the management of reflux esophagitis.

Chemical Properties

White Crystalline Solid

Originator

Astra (Sweden)

Uses

Omeprazole is a proton pump inhibitor used to treat diseases like gastroesophageal reflux disease (GERD), used for gastric and duodenal ulcers, reflux or erosive esophagitis, and Zollinger-Ellison syndrome. It is also effective for gastric and duodenal ulcers that are ineffective with H2 receptor antagonists. Injections of Omeprazole can also be used for: 1 gastrointestinal bleeding, such as peptic and anastomic ulcer bleeding, and the prevention of severe diseases (such as cerebral hemorrhage, severe trauma, etc.) and gastric surgery caused by upper intestinal bleeding; 2 acute gastric mucosal damage complicated by stress or nonsteroidal anti-inflammatory drugs; 3 general anesthesia, post-surgery, or coma patients, to prevent acid reflux and aspiration pneumonia; 4 Combined with amoxicillin and clarithromycin, or with metronidazole and clarithromycin, it can effectively kill Helicobacter pylori (Hp).

Preparation

The antiulcer agent omeprazole is produced from 2,3,5-trimethylpyridine N-oxide.
Synthesis and Structure of Omeprazole

Steps: 2-(Lithium methyl sulphinyl)-5-methoxy-1H benzimidazole 20g was reacted with 2-chloro-3,5-dimethyl-4-methoxy pyridine 21 g to form sulphide intermediate and then converted to Omeprazole when treated with m-CPBA which used as anoxidizingagents. The acetamide-sulfide compounds modification are oxidised to form the amide sulfinyl compound and gives the sulfinyl carboxylate or salts upon alkaline hydrolysis.On further decarboxylation leads to the target molecules. The residual, unreacted salt, inorganic by-products and other minor by-products can be easily purified by a simple washing from omeprazole or lansoprazole. The amide compounds containing crystalline solids as opposed to the sulphide and sulfoxides of the reported procedures.
DOI: http://dx.doi.org/10.20902/IJPTR.2019.120307

Application

Omeprazole is a benzimidazole with selective and irreversible proton pump inhibition activity. Omeprazole forms a stable disulfide bond with the sulfhydryl group of the hydrogen-potassium (H+ - K+) ATPase found on the secretory surface of parietal cells, thereby inhibiting the final transport of hydrogen ions (via exchange with potassium ions) into the gastric lumen and suppressing gastric acid secretion. This agent exhibits no anticholinergic activities and does not antagonize histamine H2 receptors. Omeprazole Pellets are used in the treatment of Gastroesophageal reflux disease (GERD): A condition in which backward flow of acid from the stomach causes heartburn and injury of the food pipe (esophagus).

Definition

ChEBI: Omeprazole is a member of the class of benzimidazoles that is 1H-benzimidazole which is substituted by a [4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl group at position 2 and a methoxy group at position 5.

brand name

Prilosec (Astra Zeneca).

Therapeutic Function

Antiulcer

World Health Organization (WHO)

Omeprazole was introduced in the 1980s. It belongs to a group of agents that have an inhibitory effect on the secretion of hydrochloric acid in the stomach (gastric acid proton pump inhibitors) and is used in the treatment of upper gastrointestinal tract disorders. The Committee for Proprietary Medicinal Products of the European Commission has concluded that a causal association between the reactions reported in Germany and the use of omeprazole had not been established. Nevertheless oral administration should be preferred. (Reference: (CPMPPO) Pharmacovigilance Opinion, No.16 , , 25 July 1994)

General Description

Omeprazole, 5-methoxy-2-(((4-methoxy-3, 5-dimethyl-2-pyridinyl)methyl) sulfinyl)-1Hbenzimidazole(Losec), is a white to off-white crystallinepowder with very slight solubility in water. Omeprazole isan amphoteric compound (pyridine N, pKa 4.06; benzimidazoleN-H, pKa 0.79), and consistent with the proposedmechanism of action of the substituted benzimidazoles, isacid labile. Hence, the omeprazole product is formulatedas delayed-release capsules containing enteric-coatedgranules.
The absolute bioavailability of orally administeredorneprazole is 30% to 40% related to substantial first-passbiotransformation. The drug has a plasmahalf-life of about 1 hour. Most (77%) of an oral dose ofomeprazole is excreted in the urine as metabolites with insignificantantisecretory activity. The primary metabolitesof omeprazole are 5-hydroxyomeprazole (CYP2C19) andomeprazole sulfone (CYP3A4). The antisecretory actions ofomeprazole persist for 24 to 72 hours, long after the drughas disappeared from plasma, which is consistent with itssuggested mechanism of action involving irreversible inhibitionof the proton pump.
Omeprazole is approved for the treatment of heartburn,GERD, duodenal ulcer, erosive esophagitis, gastric ulcer,and pathological hypersecretory conditions.

Biological Activity

H + ,K + -ATPase inhibitor (IC 50 = 5.8 μ M) that displays antisecretory and antiulcer activity. Inhibits gastric acid secretion (IC 50 = 0.16 μ M for histamine-induced acid formation) and reduces gastric lesion formation induced by a variety of ulcerative stimuli. Antibacteral against Helicobacter pylori in vitro . Also inhibits CYP2C19, CYP2C9 and CYP3A (K i values are 3.1, 40.1 and 84.4 μ M respectively) and blocks swelling-dependent chloride channels (ICIswell).

Biochem/physiol Actions

Omeprazole binds covalently to proton pump (H+, K+-ATPase) and inhibits gastric secretion. It is useful in ameliorating the effects of peptic oesophagitis, duodenal and gastric ulcer. Omeprazole is preferred over antagonists of histamine H2-receptor and ranitidine for its higher efficiency. It is also useful in treating Zollinger-Ellison syndrome.

Clinical Use

Omeprazole is a proton-pump inhibitor used in the management and treatment of several conditions, including uncomplicated heartburn, peptic ulcer disease, gastrointestinal reflux disease, Zollinger-Ellison syndrome, multiple endocrine adenomas, systemic mastocytosis, erosive esophagitis, gastric ulcers, and helicobacter pylori infection.

Side effects

The aforementioned adverse events published as case reports seem to be extremely rare relative to the large number of treatment courses with omeprazole of well above 100 million. Some of these adverse effects, however, disappeared upon cessation of omeprazole therapy and reappeared upon rechallenge suggesting a causal relationship. These include cases of myopathy , neuromyositis , erythema nodosum , arthralgia , pityriasis rosea-like skin eruption , hemolytic anemia , interstitial nephritis , , CNSsymptoms , , and acute gout .

Veterinary Drugs and Treatments

Omeprazole is potentially useful in treating both gastroduodenal ulcer disease and to prevent or treat gastric erosions caused by ulcerogenic drugs (e.g., aspirin). An oral paste product is labeled for the treatment and prevention of recurrence of gastric ulcers in horses.

Drug interactions

Potentially hazardous interactions with other drugs
Anticoagulants: effect of coumarins possibly enhanced.
Antiepileptics: effects of phenytoin possibly enhanced.
Antifungals: absorption of itraconazole and ketoconazole reduced; avoid with posaconazole; concentration increased by voriconazole.
Antivirals: reduced atazanavir concentration - avoid; AUC of saquinavir increased by 82% (increased risk of toxicity) - avoid; concentration of raltegravir possibly increased - avoid; concentration of rilpivirine reduced - avoid; concentration of omeprazole reduced by tipranavir.
Ciclosporin: variable response; mostly increase in ciclosporin level.
Cilostazol: increased cilostazol concentration - reduce cilostazol dose.
Clopidogrel: avoid due to reduced efficacy of clopidogrel.
Cytotoxics: possibly reduced excretion of methotrexate; avoid with erlotinib and vandetanib; possibly reduced dasatinib and lapatinib absorption - avoid with dasatinib; possibly reduced absorption of pazopanib.
Tacrolimus: may increase tacrolimus concentration.
Ulipristal: reduced contraceptive effect, avoid with high dose ulipristal.

Metabolic pathway

When male humans are given 14C-omeprazole orally, an average of 79% of the dose is recovered in the urine in 96 h. Omeprazole is completely metabolized and at least six metabolites are identified. Two major metabolites are hydroxyomeprazole and omeprazole acid.

Metabolism

Omeprazole is completely metabolised in the liver by the cytochrome P450 system to form inactive metabolites which are excreted mostly in the urine and to a lesser extent in bile. CYP2C19 produces hydroxyomeprazole, the major metabolite, CYP3A4 produces omeprazole sulphone.

Mode of action

Omeprazole is a proton pump inhibitor which can specifically act on gastric parietal cell proton pump sites and transform into the active form of sulfonamide, then irreversibly binds to the proton pumps through disulfide bonds, generating a sulfonamide and proton pump compound (H + -K + -ATP), thereby inhibiting the enzymatic activity, preventing the H+ in parietal cells from being transported to the stomach cavity. It has a strong and persistent inhibitory role on gastric acid secretion caused by basal gastric acid and pentapeptide gastric acid secretions, greatly reducing gastric acid within the gastric juice. Rapid, reversible, and no H2 antagonist-induced psychiatric side effects.

References

1) Satoh?et al.?(1989),?Antisecretory and antiulcer activities of a novel proton pump inhibitor AG-1749 in dogs and rats; J. Pharmacol. Exp. Ther.,?248?806
2) Kuzin?et al.?(2018),?Effects of the Proton Pump Inhibitors Omeprazole and Pantoprazole on the Cytochrome P450-Mediated Metabolism of Venlafaxine; Clin. Pharmacokinet,?57?729
3) Schmarda?et al.?(2000)?The gastric H,K-ATPase blocker Iansoprazole is an inhibitor of chloride channels; Br. J. Pharmacol.,?129?598
4) Maejima?et al.?(2020),?Oral oxytocin delivery with proton pump inhibitor pretreatment decreases food intake; Peptides,?128?170312
5) Wantanabe?et al.?(2020),?Selective Targeting of Virus Replication by Proton Pump Inhibitors; Sci. Rep.,?10?4003
6) Bojkova?et al.?(2020),?SARS-CoV2 and SARS-CoV differ in their cell tropism and drug sensitivity profiles;?bioRxiv, epub ahead of print?DOI: 10.1101/2020.04.03.024257

Omeprazole Preparation Products And Raw materials

Raw materials

Potassium ethylxanthate Benzimidazole 3-Chloroperoxybenzoic acid Chloroform 3,5-Dimethyl-4-methoxy-2-pyridinemethanol 2-MERCAPTO-5-METHOXYBENZIMIDAZOLE o-Phenylenediamine

Preparation Products

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View Lastest Price from Omeprazole manufacturers

Henan Suikang Pharmaceutical Co.,Ltd.
Product
Omeprazole 73590-58-6
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
0.99
Supply Ability
1tons
Release date
2024-04-26
Hebei Mujin Biotechnology Co.,Ltd
Product
Omeprazole Powder 73590-58-6
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US $150.00/Kg/Bag
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25Kg/Bag
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99.99%
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Release date
2021-10-08
Hebei Mujin Biotechnology Co.,Ltd
Product
Omeprazole 73590-58-6
Price
US $0.00/Kg/Bag
Min. Order
1Kg/Bag
Purity
99%
Supply Ability
5000kg/month
Release date
2021-10-12

73590-58-6, OmeprazoleRelated Search:

Dimethyl fumarate Dimethyl ether 2-Methoxyethanol ETHANE (Trifluoromethoxy)benzene 2,6-Lutidine Phenformin Dimethyl carbonate Benzimidazole Dimethyl phthalate Dimethyl sulfoxide N,N-Dimethylformamide Pantoprazole Rabeprazole Lansoprazole 4-Hydroxy Omeprazole Ufiprazole OMEPRAZOLE SULPHONE

  • 1h-benzimidazole,5-methoxy-2-(((4-methoxy-3,5-dimethyl-2-pyridinyl)methyl)sulf
  • 2-Chloromethyl-3,5-dinmethyl-4-methoxypyridine
  • 5-methoxy-2-(((4-methoxy-3,5-dimethyl-2-pyridyl)methyl)sulfinyl)benzimidazol
  • audazol
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  • belmazol
  • ceprandal
  • elgam
  • emeproton
  • gastrimut
  • indurgan
  • miol
  • omapren
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  • parizac
  • pepticum
  • prysma
  • sanamidol
  • secrepina
  • ulceral
  • ulcometion
  • ulcsep
  • zimor
  • 5-METHOXY-2-[[(4-METHOXY-3,5-DIMETHYL-2-PYRIDINYL)METHYL]SULFINYL]-1H-BENZIMIDAZOLE
  • 5-METHOXY-2[(4-METHOXY-3,5-DIMETHYL-2-PYRIDYL)METHYLSULFINYL]-1H-BENZIMIDAZOLE
  • 2-[(4-METHOXY-3,5-DIMETHYLPYRID-2-YL)-METHYLSULFO]-5-METHOXYBENZIMIDAZOLE
  • H 168/68
  • GASTROLOC
  • GASTROGARD
  • ANTRA
  • ZOLTUM
  • (S)-OMEPRAZOLE
  • R-(+)-OMEPRAZOLE
  • PRILOSEC
  • OMEPRAZOLE
  • OMEPRAL
  • MOPRAL
  • LOSEC
  • MEPRAL
  • OMEPRAZOL
  • 6-methoxy-2-[(4-methoxy-3,5-dimethyl-pyridin-2-yl)methylsulfinyl]-1H-benzimidazole
  • 6-methoxy-2-[(4-methoxy-3,5-dimethylpyridin-2-yl)methylsulfinyl]-1H-benzimidazole
  • 1H-Benzimidazole, 6-methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]sulfinyl]-
  • Omeprazole,5-Methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]sulfinyl]-1H-benzimidazole, Antra, Losec
  • OMeprazole Pellets 8.5%
  • 6-Methoxy-2-[(S)-[(4-Methoxy-3,5-diMethylpyridin-2-yl)Methane]sulfinyl]-1H-1,3-benzodiazole
  • OMeprazole, INN, Antra, Losec, Audazol, OMapren, BelMazol, Ceprandal, EMeproton, GastriMut, Indurgan
  • 6-Methoxy-2-[[(4-Methoxy-3,5-diMethyl-2-pyridinyl)Methyl]sulfinyl]-1H-benziMidazole
  • OMeprazole COS
  • EsoMeprazol iMpurity F
  • OMeprazole (EP)
  • (RS)-5-Methoxy-2-(4-methoxy-3,5-dimethyl-2-pyridylmethylsulphinyl)benzimidazole
  • EsoMeprazo API
  • OMeprazole 0.1
  • OMEPRAZOLE BASE
  • 6-methoxy-2-((4-methoxy-3,5-dimethylpyridin-2-yl)methylsulfinyl)-1H-benzo[d]imidazole
  • Esomeprazole Magnesium Trihydrate Imp. F (EP)
  • Omeprazole solution