Diflubenzuron
Description- Product Name
- Diflubenzuron
- CAS No.
- 35367-38-5
- Chemical Name
- Diflubenzuron
- Synonyms
- DIMILIN;Largon;3-(2,6-Difluorobenzoyl)-1-(4-chlorophenyl)urea;th6040;PH60-40;ph-6040;oms1804;DIMILAN;astonex;th60-40
- CBNumber
- CB8162496
- Molecular Formula
- C14H9ClF2N2O2
- Formula Weight
- 310.68
- MOL File
- 35367-38-5.mol
Diflubenzuron Property
- Melting point:
- 230-232°C
- Density
- 1.4301 (estimate)
- vapor pressure
- 1.2 x l0-4 mPa (25 °C)
- storage temp.
- 0-6°C
- solubility
- DMF: 10 mg/ml,DMSO: 10 mg/ml,DMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml
- pka
- 8.78±0.46(Predicted)
- form
- Solid
- Water Solubility
- 0.008 g/100 mL
- Merck
- 13,3166
- BRN
- 2162461
- CAS DataBase Reference
- 35367-38-5(CAS DataBase Reference)
- NIST Chemistry Reference
- Difluron(35367-38-5)
- EPA Substance Registry System
- Diflubenzuron (35367-38-5)
Safety
- Hazard Codes
- C,N
- Risk Statements
- 50/53
- Safety Statements
- 60-61
- RIDADR
- 3077
- WGK Germany
- 2
- RTECS
- YS6200000
- HazardClass
- 9
- PackingGroup
- III
- HS Code
- 2924210090
- Hazardous Substances Data
- 35367-38-5(Hazardous Substances Data)
- Toxicity
- LD50 in mice, rats (formulation with 50% kaolin) (g/kg): 4.64, >10 orally (Mulder, Gijswijt)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H312Harmful in contact with skin
H410Very toxic to aquatic life with long lasting effects
- Precautionary statements
-
P273Avoid release to the environment.
P280Wear protective gloves/protective clothing/eye protection/face protection.
N-Bromosuccinimide Price
- Product number
- 77070
- Product name
- Diflubenzuron
- Purity
- certified reference material, TraceCERT
- Packaging
- 50mg
- Price
- $247
- Updated
- 2024/03/01
- Product number
- 45446
- Product name
- Diflubenzuron
- Purity
- PESTANAL
- Packaging
- 250mg
- Price
- $81.3
- Updated
- 2024/03/01
- Product number
- 23095
- Product name
- Diflubenzuron
- Packaging
- 50mg
- Price
- $32
- Updated
- 2024/03/01
- Product number
- 23095
- Product name
- Diflubenzuron
- Packaging
- 100mg
- Price
- $61
- Updated
- 2024/03/01
- Product number
- D445520
- Product name
- Diflubenzuron
- Packaging
- 10g
- Price
- $275
- Updated
- 2021/12/16
Diflubenzuron Chemical Properties,Usage,Production
Description
Diflubenzuron is an insecticide of the benzoylurea class.It is used in forest management and on field crops to selectively control insect pests, particularly forest tent caterpillar moths, boll weevils, gypsy moths, and other types of moths.It is a widely used larvicide in India for control of mosquito larvae by public health authorities. Diflubenzuron is approved by the WHO Pesticide Evaluation Scheme.
Description
Diflubenzuron is a benzoylphenylurea insecticide that inhibits chitin synthesis in insects with an IC50 value of 0.611 nM for 14C-labeled N-acetyl-D-glucosamine incorporation in the cockroach. Specifically, it inhibits chitin synthetase at the egg and larval stages, leading to an inability to exit the egg or exocuticle, respectively. Diflubenzuron is genotoxic and mutagenic in mice at doses of 0.3, 1, and 3 mg/kg. Formulations containing diflubenzuron are used primarily in agricultural applications but are also used to control insects in livestock production.
Description
Diflubenzuron is produced by the reaction of 2,6-difluorobenzamide with 4-chlorophenylisocyanate. Diflubenzuron was first registered as a pesticide in the United States in 1979. Environmental Protection Agency issued a Registration Standard for diflubenzuron in September 1985 (PB86-176500). In 1991, a Data Call-In was made to require additional residue chemistry and ecological effects data. The current Reregistration Eligibility Decision Document was issued in August 1997, reflecting analysis of the new data.
Uses
Diflubenzuron is used for the control of a wide range of leaf-eating insects in forestry, woody ornamentals and fruit. It controls major pests on cotton, soyabean, citrus and tea and it also controls larvae of flies, mosquitoes and locusts. Diflubenzuron is also used as an ectoparasiticide.
Uses
Diflubenzuron is a benzoylurea-based pesticide belonging to the benzamide class. Diflubenzuron is a chitin synthesis inhibitor. Diflubenzuron is used in both agriculture and forest management to selec tively control insect pests, particularly moths and weevils.
Uses
Insecticide.
Uses
An inhibitor of TCDD-induced CYP1a1 expression in HepG2 cells.
Uses
nsystemic insecticide used to control leaf-eating larvae and leaf miners in forestry, woody ornamentals and fruit trees.
Definition
ChEBI: A benzoylurea insecticide that is urea in which a hydrogen attached to one of the nitrogens is replaced by a 4-chlorophenyl group, and a hydrogen attached to the other nitrogen is replaced bgy a 2,6-difluorobenzoyl group.
General Description
Colorless to yellow crystals. Used as a selective insecticide.
Air & Water Reactions
Hydrolyzed in alkaline solution above pH 9.0.
Reactivity Profile
A urea derivative.
Agricultural Uses
Insecticide, Larvicide: Diflubenzuron is used primarily on citrus, cattle feed, cotton, forestry, mushrooms, ornamentals, pastures, soybeans, standing water, sewage systems, and wide-area general outdoor treatment sites. The insecticide behaves as a chitin inhibitor to inhibit the growth of many leaf-eating larvae, mosquito larvae, aquatic midges, rust mite, boll weevil, and house-black-, and stable-flies. Diflubenzuron was first registered in the United States in 1979 for use as an insecticide.
Trade name
ADEPT®; ASTONEX®; DIMILIN®; DIMILIN® FLO; DIMILIN® WG-80; DU-112307®; DUPHAR® PH 60-40; ODC-45®; DIFLURON®; DU 112307®; LARGON®; LARVAKIL®; MICROMITE®; OMS 1804®; PDD 60401®; PH 60- 40®; PHILIPS-DUPHAR® PH 60-40; TH 60-40®; THOMPSON-HAYWARD® 6040; VIGILANTE®
Safety Profile
Moderately toxic by skin contact. Mildly toxic by ingestion. Mutation data reported. When heated to decomposition it emits very toxic fumes of Cl-, F-, and NOx.
Environmental Fate
Soil. The half-life in soil is <1 week (Hartley and Kidd, 1987). Di?ubenzuron degrades more rapidly in neutral or basic conditions but more slowly under acidic conditions (pH <6) (Ivie et al., 1980).
Chemical/Physical. Hydrolyzes in water to 4-chlorophenylurea (Verschueren, 1983).
Metabolic pathway
Diflubenzuron was the first active substance commercialised as a benzoylurea insect growth regulator and there is extensive published information on its degradation and metabolism. Detailed studies of the degradation in soils have shown that cleavage of the urea linkage is the major process. This also occurs in plants, insects and mammals but the formation of products in which diflubenzuron is hydroxylated in both rings is also an important metabolic process.
Degradation
Diflubenzuron was shown to be stable to hydrolysis in aqueous solution
at acidic pH (DT50> 56 days at pH 4) but was readily hydrolysed at pH 10
(DT50 <3 days). In distilled water the DTa was 7 days (Ivie et al., 1980).
The major degradation products isolated were 4-chlorophenylurea (2)
and 2,6-difluorobenzoic acid (3). An additional minor product was 2,6-
difluorobenzamide (4). The hydrolysis products are shown in Scheme 1.
Additional products were formed under extreme conditions (121 °C
under pressure).
Aqueous solutions of diflubenzuron are reported to be unstable to light
but the solid is stable in sunlight (PM).
Toxicity evaluation
Diflubenzuron is an odorless, white, crystalline solid with
a melting point of 230–232 C. It is almost insoluble in water (0.2 mg l1) and poorly soluble in apolar organic solvents.It is almost nonvolatile. It is relatively stable in
acidic and neutral media but hydrolyses under alkaline
conditions.
Diflubenzuron is difficult to be degraded in sterilized water
under neutral or acidic conditions. However, it is degraded
rapidly under field conditions. Application of diflubenzuron to
water resulted rapid partition to sediment; the parent
compound and 4-chlorophenylurea (CPU) may persist on
sediment for more than 30 days.
The rate of degradation of diflubenzuron in soil is strongly
dependent on the particle size. For larger particles
(10 microns), the half-life is 8–16 weeks and for smaller
particles (2 microns), it is 0.5–1 week. Almost all of the parent
compound breaks down to form 2,6-difluorobenzoic acid
(DFBA) and CPU. A very minor amount forms 4-chloroaniline
(PCA) which rapidly binds to the soil. Under field conditions,
diflubenzuron has very low mobility.
Very little diflubenzuron is absorbed, metabolized, or
translocated in plants. It also is not readily taken up from
treated soil.
Diflubenzuron has very low vapor pressure (<2×10-7 Pa
at 25°C) and its atmospheric half-life is only several hours.
Therefore, it is not expected that diflubenzuron will be present
in air for extended periods and the long-range transport and
redeposition of diflubenzuron is expected to be negligible.
Diflubenzuron Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Diflubenzuron manufacturers
- Product
- Diflubenzuron 35367-38-5
- Price
- US $120.00-65.00/kg
- Min. Order
- 1kg
- Purity
- 97%
- Supply Ability
- 20MT
- Release date
- 2024-04-17
- Product
- Diflubenzuron 35367-38-5
- Price
- US $200.00/Kg/Drum
- Min. Order
- 1KG
- Purity
- 97%;98%
- Supply Ability
- 20tons/month
- Release date
- 2020-09-01
- Product
- Diflubenzuron 35367-38-5
- Price
- US $10.00/Kg/Drum
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 10 ton
- Release date
- 2021-07-29