ChemicalBook > CAS DataBase List > PROSTACYCLIN SODIUM SALT

PROSTACYCLIN SODIUM SALT

Product Name
PROSTACYCLIN SODIUM SALT
CAS No.
61849-14-7
Chemical Name
PROSTACYCLIN SODIUM SALT
Synonyms
PGI2;Flolan;PG12-NA;PGI2-NA;PGI2 sodium;Sodium PGI2;EPOPROSTENOL;Eprostol sodium;PROSTAGLANDIN I2;Prostaglandin 12
CBNumber
CB8167138
Molecular Formula
C20H33NaO5
Formula Weight
376.47
MOL File
61849-14-7.mol
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PROSTACYCLIN SODIUM SALT Property

Melting point:
168-170 °C
RTECS 
UK8008700
storage temp. 
-20°C
solubility 
H2O: 1 mg/mL Hydrolyzes to 6-ketoprostaglandin F1α in aqueous solution.
form 
powder
color 
white
Water Solubility 
Soluble to 100 mM in water
Sensitive 
Moisture Sensitive
Merck 
13,7967
BRN 
6472195
Stability:
Light Sensitive, Temperature Sensitive
CAS DataBase Reference
61849-14-7(CAS DataBase Reference)
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Safety

Hazard Codes 
Xn
Risk Statements 
20/21/22
Safety Statements 
22-26-36
WGK Germany 
3
F 
3-10
HS Code 
29329900
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H312Harmful in contact with skin

H332Harmful if inhaled

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P321Specific treatment (see … on this label).

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
1237600
Product name
Epoprostenol sodium
Purity
United States Pharmacopeia (USP) Reference Standard
Packaging
100mg
Price
$3490
Updated
2024/03/01
Alfa Aesar
Product number
J67115
Product name
Prostaglandin I2 sodium salt, 99%
Packaging
1mg
Price
$159
Updated
2023/06/20
Cayman Chemical
Product number
18220
Product name
Prostaglandin I2 (sodium salt)
Purity
≥98%
Packaging
1mg
Price
$73
Updated
2024/03/01
Cayman Chemical
Product number
18220
Product name
Prostaglandin I2 (sodium salt)
Purity
≥98%
Packaging
5mg
Price
$324
Updated
2024/03/01
Sigma-Aldrich
Product number
P6188
Product name
Prostaglandin I2 sodium salt
Purity
≥96% (HPLC), synthetic, powder
Packaging
1mg
Price
$435
Updated
2024/03/01
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PROSTACYCLIN SODIUM SALT Chemical Properties,Usage,Production

Description

Epoprostenol is a naturally occurring prostaglandin indicated for the preservation of platelet function during cardiopulmonary bypass, prevention of platelet aggregation during charcoal hemoperfusion of patients in hepatic failure, and as an alternative to heparin during renal dialysis.

Chemical Properties

Epoprostenol is white crystalline powder

Originator

Burroughs Wellcome (United Kingdom)

Uses

Prostaglandin I2 sodium salt has been used:

  • in the preparation of stock solution for platelet washing procedure
  • as supplement in platelet-rich-plasma, for platelet preparation
  • to prevent platelet activation

Uses

Epoprostenol is an Eicosanoid which prevents the formation of platelet plugs and is an effective vasodilator.

Manufacturing Process

Preparation of prostacyclin:
Pig aortas were stripped of adventitia, snap frozen in liquid nitrogen, crushed into a fine powder, resuspended in 0.05 M Tris buffer (pH 7.5) (1:4, w:v) andhomogenised at high speed in a Polytron (KIMENATIC, LUCERNE, SWITZERLAND) homogenizer. The homogenate was centrifuged for 15 min and the resulting supernatant centrifuged again for 5 min. The pellet was discarded, while the pellet obtained after centrifugation of the supernatant was resuspended in deionized water and lyophilized. An average yield of 150 mg of aortic microsomal powder (51% protein) per 100 g of aortic tissue was obtained.

brand name

Flolan (GlaxoSmithKline);CYCLO-PROSTIN.

Therapeutic Function

Platelet aggregation inhibitor, Antimetastatic

Biological Activity

Epoprostenol is a potent agonist at IP prostanoid receptors. Inhibits platelet aggregation and induces vasodilation.

Biochem/physiol Actions

Prostacyclin therapy improves hemodynamics in pulmonary arterial hypertension.

storage

Desiccate at -80°C

PROSTACYCLIN SODIUM SALT Preparation Products And Raw materials

Raw materials

Preparation Products

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PROSTACYCLIN SODIUM SALT Suppliers

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View Lastest Price from PROSTACYCLIN SODIUM SALT manufacturers

Career Henan Chemical Co
Product
PROSTACYCLIN SODIUM SALT 61849-14-7
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
25kg
Release date
2019-07-12

61849-14-7, PROSTACYCLIN SODIUM SALTRelated Search:

PROSTAGLANDIN F1ALPHA Latanoprost Misoprostol Acid REMODULIN 5-Aminosalicylic acid 13,14-DIHYDROPROSTAGLANDIN E1 Prostaglandin F2a PROSTAGLANDIN D2 6(R)-(4-CARBOXYPHENYLTHIO)-5(S)-HYDROXY-7(E),9(E),11(Z),14(Z)-EICOSATETRAENOIC ACID L-161,982 11BETA-PROSTAGL AND IN F2ALPHA LEUKOTRIENE B4 DIMETHYL AMIDE LEUKOTRIENE D4 Epoprostenol PROSTACYCLIN SODIUM SALT 5-CAPROLEIC ACID 5-TRANS PROSTAGLANDIN F2ALPHA PROSTACYCLIN

  • EPOPROSTENOL
  • EPOPROSTENOL SODIUM
  • EPOPROSTENOL SODIUM SALT
  • (5-Z)-9-DEOXY-6,9ALPHA-EPOXY-PGF1ALPHA, SODIUM SALT
  • [5Z,9ALPHA,11ALPHA,13E,15S]-6,9-EPOXY-11,15-DIHYDROXYPROSTA-5,13-DIEN-1-OIC ACID SODIUM SALT
  • 6,9ALPHA-EPOXY-11ALPHA,15S-DIHYDROXY-PROSTA-5Z,13E-DIEN-1-OIC ACID, SODIUM SALT
  • PROSTACYCLINE SODIUM SALT
  • PROSTACYCLIN SODIUM SALT
  • PROSTAGLANDINS I2 SODIUM SALT
  • PROSTAGLANDIN I2
  • PROSTAGLANDIN I2 NA
  • PROSTAGLANDIN I2 SODIUM SALT
  • PG12-NA
  • PGI2
  • PGI2-NA
  • PGI2, SODIUM SALT
  • (5z,9α,11α,13e,15s)-6,9-epoxy-11,15-dihydroxyprosta-5,13-dien-1-oic acid sodium salt
  • Flolan
  • PGI2 sodium
  • Prosta-5,13-dien-1-oic acid, 6,9-epoxy-11,15-dihydroxy-, monosodium salt, (5Z,9α,11α,13E,15S)-
  • Prostacyclin sodium
  • Sodium PGI2
  • Sodium prostacyclin
  • Epoprostenol sodium salt, PGI2-Na, Prostacyclin sodium salt, (5Z,9α,11α,13E,15S)-6,9-Epoxy-11,15-dihydroxyprosta-5,13-dien-1-oic acid sodium salt
  • sodium (5Z,13E,15S)-6,9alpha-epoxy-11alpha,15-dihydroxyprosta-5,13-dien-1-oate
  • PROSTAGLANDIN I2 SODIUM
  • Prostaglandin 12
  • (5-Z)-9-DEOXY-6,9ALPHA-EPOXY-PGF1ALPHA, SODIUM SALT, 98%, STABILIZED
  • (5-Z)-9-Deoxy-6,9alpha-epoxy-PGF1alpha, sodium salt, stabilized
  • Sodium (5Z,13E,15S)-6,9a-epoxy-11a,15-dihydroxyprosta-5,13-dien-1-oate
  • cGMP Epoprostenol (sodium salt)
  • (5Z,13E,8R,9S,11R,12R,15S)-6,9-Epoxy-11,15-dihydroxyprosta-5,13-dien-1-oicacidsodiumsalt
  • Prostacyclin sodium salt Epoprostenol sodium
  • PGI2Na (Prostaglandin I2Na, Prostacyclin)
  • Prostaglandin I?, Sodium Salt
  • (5Z)-5-[(3aR,4R,5R,6aS)-5-hydroxy-4-[(E,3S)-3-hydroxyoct-1-enyl]-3,3a,4,5,6,6a-hexahydrocyclopenta[b]furan-2-ylidene]pentanoate
  • Prostaglandin I, Sodium Salt - CAS 61849-14-7 - Calbiochem
  • PROSTACYCLIN SODIUM SALT USP/EP/BP
  • Epoprostenol ELISA Kit
  • Epoprostenol sodiumQ: What is Epoprostenol sodium Q: What is the CAS Number of Epoprostenol sodium Q: What is the storage condition of Epoprostenol sodium Q: What are the applications of Epoprostenol sodium
  • TIANFU CHEM--PROSTACYCLIN SODIUM SALT
  • Epoprostenol Sodium (COLD SHIPMENT REQUIRED) (1237600)
  • Eprostol sodium
  • 61849-14-7
  • C20H32NaO5
  • C20H31O5Na
  • C20H31NaO5
  • Fatty Acids
  • Lipids
  • Prostaglandins
  • Biochemicals and Reagents
  • BioChemical
  • Chiral Reagents
  • Intermediates & Fine Chemicals
  • Pharmaceuticals