4-Bromo-2-(trifluoromethyl)phenol

Product Name: 4-Bromo-2-(trifluoromethyl)phenol
CAS No.: 50824-04-9
Chemical Name: 4-Bromo-2-(trifluoromethyl)phenol
Synonyms: 5-Bromo-2-hydroxyBenzotrifluoride;4-BROMO-2-(TRIFLUOROMETHYL)PHENOL;4-BroMo-2-(trifluoroMethyl)phenol4;4-BROMO-2-(TRIFLUOROMETHYL)BENZENOL;4-Beromo-2-(trifluoromethyl)benzenol;Phenol, 4-bromo-2-(trifluoromethyl)-;4-Bromo-2-(trifluoromethyl)phenol >5-Bromo-2-hydroxybenzotrifluoride 99%;4-broMo -2-three fluorineMethyl phenol;4-Bromo-2-(trifluoromethyl)phenol, 4-Bromo-alpha,alpha,alpha-trifluoro-o-cresol
CBNumber: CB8179670
Molecular Formula: C7H4BrF3O
Formula Weight: 241.01
MOL File: 50824-04-9.mol

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4-Bromo-2-(trifluoromethyl)phenol Property

Melting point:: 83-85°
Boiling point:: 203.4±35.0 °C(Predicted)
Density: 1.752±0.06 g/cm3(Predicted)
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
pka: 7.41±0.43(Predicted)
form: Crystalline Powder
color: White
InChI: InChI=1S/C7H4BrF3O/c8-4-1-2-6(12)5(3-4)7(9,10)11/h1-3,12H
InChIKey: PDPGERGWEOJVDC-UHFFFAOYSA-N
SMILES: C1(O)=CC=C(Br)C=C1C(F)(F)F

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Safety

Hazard Codes: T
HazardClass: IRRITANT
HS Code: 2908190090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: KOB0023
Product name: 4-Bromo-2-(trifluoromethyl)benzenol
Packaging: 1 g
Price: $179
Updated: 2025/07/31

TCI Chemical

Product number: B4493
Product name: 4-Bromo-2-(trifluoromethyl)phenol
Purity: >97.0%(GC)
Packaging: 5g
Price: $59
Updated: 2025/07/31

TCI Chemical

Product number: B4493
Product name: 4-Bromo-2-(trifluoromethyl)phenol
Purity: >97.0%(GC)
Packaging: 25g
Price: $236
Updated: 2025/07/31

TRC

Product number: B695958
Product name: 4-Bromo-2-trifluoromethylphenol
Packaging: 500mg
Price: $65
Updated: 2021/12/16

AK Scientific

Product number: J50923
Product name: 4-Bromo-2-(trifluoromethyl)phenol
Packaging: 1g
Price: $10
Updated: 2021/12/16

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4-Bromo-2-(trifluoromethyl)phenol Chemical Properties,Usage,Production

Chemical Properties

light yellow crystalline

Synthesis

444-30-4

50824-04-9

General procedure for the synthesis of 4-bromo-2-trifluoromethylphenol from o-trifluoromethylphenol: o-trifluoromethylphenol (6.0 g, 37 mmol) was dissolved in trifluoroacetic acid (30 ml), then bromine (5.91 g, 37 mmol) was added slowly and dropwise at room temperature. The reaction mixture was stirred for 2 hours. After completion of the reaction, ethyl acetate (200 ml) was added for extraction. The organic phase was washed sequentially with brine (50 mL x 2), saturated sodium carbonate solution (50 mL x 2) and brine (50 ml), and then dried with anhydrous sodium sulfate. The organic phase was concentrated under reduced pressure to give 4-bromo-2-trifluoromethylphenol (gray solid, 8.9 g, yield: 100%).

References

[1] Patent: CN105732602, 2016, A. Location in patent: Paragraph 0094; 0096; 0097; 0098; 0099
[2] Journal of Medicinal Chemistry, 2014, vol. 57, # 5, p. 2107 - 2120
[3] Patent: WO2014/209034, 2014, A1. Location in patent: Paragraph 541; 542; 543
[4] Synthesis, 1999, # 11, p. 1878 - 1880
[5] Bulletin of the Chemical Society of Japan, 2004, vol. 77, # 12, p. 2257 - 2263

4-Bromo-2-(trifluoromethyl)phenol Preparation Products And Raw materials

Raw materials

Preparation Products

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4-Bromo-2-(trifluoromethyl)phenol Suppliers

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View Lastest Price from 4-Bromo-2-(trifluoromethyl)phenol manufacturers

Career Henan Chemical Co

Product: 4-Bromo-2-(trifluoromethyl)phenol 50824-04-9
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 100KG
Release date: 2020-01-02

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50824-04-9

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