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4-Bromo-2-(trifluoromethyl)phenol

Product Name
4-Bromo-2-(trifluoromethyl)phenol
CAS No.
50824-04-9
Chemical Name
4-Bromo-2-(trifluoromethyl)phenol
Synonyms
5-Bromo-2-hydroxyBenzotrifluoride;4-BROMO-2-(TRIFLUOROMETHYL)PHENOL;4-BroMo-2-(trifluoroMethyl)phenol4;4-BROMO-2-(TRIFLUOROMETHYL)BENZENOL;4-Beromo-2-(trifluoromethyl)benzenol;Phenol, 4-bromo-2-(trifluoromethyl)-;4-Bromo-2-(trifluoromethyl)phenol >5-Bromo-2-hydroxybenzotrifluoride 99%;4-broMo -2-three fluorineMethyl phenol;4-Bromo-2-(trifluoromethyl)phenol, 4-Bromo-alpha,alpha,alpha-trifluoro-o-cresol
CBNumber
CB8179670
Molecular Formula
C7H4BrF3O
Formula Weight
241.01
MOL File
50824-04-9.mol
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4-Bromo-2-(trifluoromethyl)phenol Property

Melting point:
83-85°
Boiling point:
203.4±35.0 °C(Predicted)
Density 
1.752±0.06 g/cm3(Predicted)
storage temp. 
Keep in dark place,Sealed in dry,Room Temperature
pka
7.41±0.43(Predicted)
form 
Crystalline Powder
color 
White
InChI
InChI=1S/C7H4BrF3O/c8-4-1-2-6(12)5(3-4)7(9,10)11/h1-3,12H
InChIKey
PDPGERGWEOJVDC-UHFFFAOYSA-N
SMILES
C1(O)=CC=C(Br)C=C1C(F)(F)F
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Safety

Hazard Codes 
T
HazardClass 
IRRITANT
HS Code 
2908190090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
KOB0023
Product name
4-Bromo-2-(trifluoromethyl)benzenol
Packaging
1 g
Price
$179
Updated
2025/07/31
TCI Chemical
Product number
B4493
Product name
4-Bromo-2-(trifluoromethyl)phenol
Purity
>97.0%(GC)
Packaging
5g
Price
$59
Updated
2025/07/31
TCI Chemical
Product number
B4493
Product name
4-Bromo-2-(trifluoromethyl)phenol
Purity
>97.0%(GC)
Packaging
25g
Price
$236
Updated
2025/07/31
TRC
Product number
B695958
Product name
4-Bromo-2-trifluoromethylphenol
Packaging
500mg
Price
$65
Updated
2021/12/16
Biosynth Carbosynth
Product number
FB67200
Product name
4-Bromo-2-(trifluoromethyl)phenol
Packaging
25g
Price
$75
Updated
2021/12/16
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4-Bromo-2-(trifluoromethyl)phenol Chemical Properties,Usage,Production

Chemical Properties

light yellow crystalline

Synthesis

444-30-4

50824-04-9

General procedure for the synthesis of 4-bromo-2-trifluoromethylphenol from o-trifluoromethylphenol: o-trifluoromethylphenol (6.0 g, 37 mmol) was dissolved in trifluoroacetic acid (30 ml), then bromine (5.91 g, 37 mmol) was added slowly and dropwise at room temperature. The reaction mixture was stirred for 2 hours. After completion of the reaction, ethyl acetate (200 ml) was added for extraction. The organic phase was washed sequentially with brine (50 mL x 2), saturated sodium carbonate solution (50 mL x 2) and brine (50 ml), and then dried with anhydrous sodium sulfate. The organic phase was concentrated under reduced pressure to give 4-bromo-2-trifluoromethylphenol (gray solid, 8.9 g, yield: 100%).

References

[1] Patent: CN105732602, 2016, A. Location in patent: Paragraph 0094; 0096; 0097; 0098; 0099
[2] Journal of Medicinal Chemistry, 2014, vol. 57, # 5, p. 2107 - 2120
[3] Patent: WO2014/209034, 2014, A1. Location in patent: Paragraph 541; 542; 543
[4] Synthesis, 1999, # 11, p. 1878 - 1880
[5] Bulletin of the Chemical Society of Japan, 2004, vol. 77, # 12, p. 2257 - 2263

4-Bromo-2-(trifluoromethyl)phenol Preparation Products And Raw materials

Raw materials

Preparation Products

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4-Bromo-2-(trifluoromethyl)phenol Suppliers

Americas 1 China 139 Europe 1 Germany 3 India 6 Italy 1 Japan 1 United Kingdom 12 United States 25 Global 189
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View Lastest Price from 4-Bromo-2-(trifluoromethyl)phenol manufacturers

Career Henan Chemical Co
Product
4-Bromo-2-(trifluoromethyl)phenol 50824-04-9
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
100KG
Release date
2020-01-02

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