5-Nitrobenzothiophene
- Product Name
- 5-Nitrobenzothiophene
- CAS No.
- 4965-26-8
- Chemical Name
- 5-Nitrobenzothiophene
- Synonyms
- 5-nitrobenzo[b]thiophene;5-NITROBENZOTHIOPHENE;5-nitro-1-benzothiophene;Benzo[b]thiophene, 5-nitro-;5-Nitrobenzothiophene ISO 9001：2015 REACH
- CBNumber
- CB8208222
- Molecular Formula
- C8H5NO2S
- Formula Weight
- 179.2
- MOL File
- 4965-26-8.mol
5-Nitrobenzothiophene Property
- Melting point:
- 149-150 °C
- Boiling point:
- 324.6±15.0 °C(Predicted)
- Density
- 1.435±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C(protect from light)
- Appearance
- Light yellow to brown Solid
Safety
- HS Code
- 2934999090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- N495033
- Product name
- 5-Nitrobenzo[b]thiophene
- Packaging
- 100mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- CS-W006433
- Product name
- 5-Nitrobenzo[b]thiophene
- Purity
- ≥98.0%
- Packaging
- 250mg
- Price
- $61
- Updated
- 2021/12/16
- Product number
- OR938440
- Product name
- 5-Nitrobenzothiophene
- Purity
- 95%
- Packaging
- 250mg
- Price
- $115
- Updated
- 2021/12/16
- Product number
- Y9213
- Product name
- 5-Nitrobenzo[b]thiophene
- Packaging
- 250mg
- Price
- $154
- Updated
- 2021/12/16
- Product number
- CS-W006433
- Product name
- 5-Nitrobenzo[b]thiophene
- Purity
- ≥98.0%
- Packaging
- 5g
- Price
- $188
- Updated
- 2021/12/16
5-Nitrobenzothiophene Chemical Properties,Usage,Production
Synthesis
6345-55-7
4965-26-8
5-Nitro-1-benzothiophene-2-carboxylic acid (40 g, 179 mmol) was dissolved in quinoline (350 mL) under mechanical stirring followed by addition of copper powder (11.3 g, 179 mmol). The reaction mixture was heated to 190°C until complete gas release. After completion of the reaction, the mixture was cooled to room temperature and poured into crushed ice and acidified with concentrated hydrochloric acid. The resulting suspension was extracted with ethyl acetate and the organic layer was separated and washed sequentially with 2N hydrochloric acid, water and saturated brine. The organic layer was dried over anhydrous sodium sulfate and concentrated to give 5-nitrobenzothiophene (30.5 g, 95% yield). The structure of the product was confirmed by 1H NMR (DMSO-d6, 400 MHz) and LC-MS (electrospray): 1H NMR δ 8.85 (d, 1H), 8.31 (d, 1H), 8.18 (dd, 1H), 8.06 (d, 1H), 7.73 (d, 1H); LC-MS m/z = 180 [M + H]+.
References
[1] Bioorganic and Medicinal Chemistry, 2016, vol. 24, # 3, p. 403 - 427
[2] ACS Medicinal Chemistry Letters, 2016, vol. 7, # 8, p. 735 - 740
[3] ACS Medicinal Chemistry Letters, 2017, vol. 8, # 3, p. 338 - 343
[4] Patent: WO2006/66172, 2006, A1. Location in patent: Page/Page column 27
[5] Synthetic Communications, 1991, vol. 21, # 7, p. 959 - 964
5-Nitrobenzothiophene Preparation Products And Raw materials
Raw materials
Preparation Products
5-Nitrobenzothiophene Suppliers
- Tel
- --
- Fax
- --
- eburon@innet.be
- Country
- Belgium
- ProdList
- 490
- Advantage
- 66
View Lastest Price from 5-Nitrobenzothiophene manufacturers
- Product
- 5-Nitrobenzothiophene 4965-26-8
- Price
- US $1.00/g
- Min. Order
- 1g
- Purity
- ≥98%
- Supply Ability
- g/kg/T
- Release date
- 2019-12-24