ChemicalBook > CAS DataBase List > 5-[[5-(4-Fluoro-2-hydroxyphenyl)-2-furanyl]methylene]-2,4-thiazolidinedione

5-[[5-(4-Fluoro-2-hydroxyphenyl)-2-furanyl]methylene]-2,4-thiazolidinedione

Product Name
5-[[5-(4-Fluoro-2-hydroxyphenyl)-2-furanyl]methylene]-2,4-thiazolidinedione
CAS No.
900515-16-4
Chemical Name
5-[[5-(4-Fluoro-2-hydroxyphenyl)-2-furanyl]methylene]-2,4-thiazolidinedione
Synonyms
CS-182;S-252424;AS-252424;AS-252424cas;AS-252424;AS 252424;5-[[5-(4-Fluoro-2-hydroxyphenyl)-2-furanyl]methylene]-2,4-thiazolidinedione;(Z)-5-((5-(4-fluoro-2-hydroxyphenyl)furan-2-yl)methylene)thiazolidine-2,4-dione;(E)-5-((5-(4-fluoro-2-hydroxyphenyl)furan-2-yl)Methylene)thiazolidine-2,4-dione;(5Z)-5-[[5-(4-Fluoro-2-hydroxyphenyl)-2-furanyl]methylene]-2,4-thiazolidinedione;2,4-Thiazolidinedione, 5-[[5-(4-fluoro-2-hydroxyphenyl)-2-furanyl]methylene]-, (5Z)-
CBNumber
CB82093286
Molecular Formula
C14H8FNO4S
Formula Weight
305.28
MOL File
900515-16-4.mol
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5-[[5-(4-Fluoro-2-hydroxyphenyl)-2-furanyl]methylene]-2,4-thiazolidinedione Property

Melting point:
>235oC (dec.)
Density 
1.559±0.06 g/cm3(Predicted)
storage temp. 
2-8°C
solubility 
DMSO: >20mg/mL
pka
7.20±0.20(Predicted)
form 
solid
color 
yellow
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Safety

WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
A8981
Product name
AS-252424
Purity
≥98% (HPLC), solid
Packaging
5mg
Price
$328
Updated
2022/05/15
Cayman Chemical
Product number
10009052
Product name
AS-252424
Purity
≥95%
Packaging
1mg
Price
$39
Updated
2024/03/01
Cayman Chemical
Product number
10009052
Product name
AS-252424
Purity
≥95%
Packaging
5mg
Price
$106
Updated
2024/03/01
Cayman Chemical
Product number
10009052
Product name
AS-252424
Purity
≥95%
Packaging
10mg
Price
$189
Updated
2024/03/01
Cayman Chemical
Product number
10009052
Product name
AS-252424
Purity
≥95%
Packaging
25mg
Price
$425
Updated
2024/03/01
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5-[[5-(4-Fluoro-2-hydroxyphenyl)-2-furanyl]methylene]-2,4-thiazolidinedione Chemical Properties,Usage,Production

Uses

AS-252424 is a novel, potent, and selective phosphoinositide 3-kinase gamma (PI3Kγ) inhibitor. It is also an inhibitor of Casein kinase and PI3K p110α.

Biological Activity

as-252424 is a potent, selective and novel small-molecule pi3kγ inhibitor (ic50= 30 nm)pi3k (phosphatidylinositol-4,5-bisphosphate 3-kinase) is a family of enzymes involved in cellular functions such as cell growth, proliferation, differentiation, motility, survival and intracellular trafficking, which in turn are involved in cancer. it plays a key role in pi3k/akt/mtor pathway.in thp-1 (human monocytic cell line), as-252424 inhibited the phosphorylation of pkb/akt due to mcp1 binding to the gpcr receptor ccr2 at lowest ic50 values of 0.4 μm. in primary monocytes and monocytic wild-type cell line thp-1, as-252424 inhibited mcp-1-mediated chemotaxis in a concentration-dependent manner (ic50 value= 52 μm and 53 μm, respectively). [1] in capan 1 and hpaf (pancreatic cancer cell lines), as52424 specifically inhibited the cell proliferation. [2]in a mouse model of thioglycollate-induced peritonitis, oral administration of as-252424 at 10 mg/kg led to moderate reduction of neutrophil recruitment (35% ±14%). [1]

Biochem/physiol Actions

AS-252424 is a potent and selective phosphoinositide 3-kinase PI3Kγ inhibitor with IC50 = 30 nM in a mouse model.

References

1. pomel v, klicic j, covini d et al. furan-2-ylmethylene thiazolidinediones as novel, potent, and selective inhibitors of phosphoinositide 3-kinase gamma. j med chem. 2006 jun 29;49(13):3857-71.2. edling ce, selvaggi f, buus r et al. key role of phosphoinositide 3-kinase class ib in pancreatic cancer. clin cancer res. 2010 oct 15;16(20):4928-37.

5-[[5-(4-Fluoro-2-hydroxyphenyl)-2-furanyl]methylene]-2,4-thiazolidinedione Preparation Products And Raw materials

Raw materials

Preparation Products

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5-[[5-(4-Fluoro-2-hydroxyphenyl)-2-furanyl]methylene]-2,4-thiazolidinedione Suppliers

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View Lastest Price from 5-[[5-(4-Fluoro-2-hydroxyphenyl)-2-furanyl]methylene]-2,4-thiazolidinedione manufacturers

Career Henan Chemical Co
Product
5-[[5-(4-Fluoro-2-hydroxyphenyl)-2-furanyl]methylene]-2,4-thiazolidinedione 900515-16-4
Price
US $2.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
100kg
Release date
2018-12-23

900515-16-4, 5-[[5-(4-Fluoro-2-hydroxyphenyl)-2-furanyl]methylene]-2,4-thiazolidinedioneRelated Search:

2'-Hydroxyacetophenone Dihydrocaffeic acid 2-HYDROXYACETOPHENONE Dihydroxybenzoic acid AS 604850 GSK2636771 Pictilisib IPI 145 CAL-101 LY 294002 HYDROCHLORIDE 4H-PYRIDO[1,2-A]PYRIMIDIN-4-ONE, 7-METHYL-2-(4-MORPHOLINYL)-9-[1-(PHENYLAMINO)ETHYL]-

  • 5-[[5-(4-Fluoro-2-hydroxyphenyl)-2-furanyl]methylene]-2,4-thiazolidinedione
  • AS-252424
  • (E)-5-((5-(4-fluoro-2-hydroxyphenyl)furan-2-yl)Methylene)thiazolidine-2,4-dione
  • (Z)-5-((5-(4-fluoro-2-hydroxyphenyl)furan-2-yl)methylene)thiazolidine-2,4-dione
  • AS 252424 5-[[5-(4-Fluoro-2-hydroxyphenyl)-2-furanyl]methylene]-2,4-thiazolidinedione
  • AS-252424;AS 252424
  • (5Z)-5-[[5-(4-Fluoro-2-hydroxyphenyl)-2-furanyl]methylene]-2,4-thiazolidinedione
  • CS-182
  • 2,4-Thiazolidinedione, 5-[[5-(4-fluoro-2-hydroxyphenyl)-2-furanyl]methylene]-, (5Z)-
  • (5Z)-5-{[5-(4-Fluoro-2-hydroxyphenyl)furan-2-yl]methylidene}-1,3-thiazolidine-2,4-dione
  • 5-[[5-(4-Fluoro-2-hydroxyphenyl)-2-furanyl]methylene]-2,4-thiazolidinedione USP/EP/BP
  • AS-252424cas
  • S-252424
  • 900515-16-4
  • C14H8FNO4S
  • Inhibitors
  • Akt
  • mTOR
  • PI3K
  • Phosphoinositide 3-kinase PI3-kinase p110γ inhibitor.
  • A phosphoinositide 3-kinase PI3-kinase p110γ inhibitor.