4-Bromo-3-nitroanisole
- Product Name
- 4-Bromo-3-nitroanisole
- CAS No.
- 5344-78-5
- Chemical Name
- 4-Bromo-3-nitroanisole
- Synonyms
- TIMTEC-BB SBB009974;4-Brom-3-nitroanisol;4-Bromo-3-nitroanisol;4-BROMO-3-NITROANISOLE;4-Bromo-3-nitroanlsole;4-BROMO-3-NITROTHIOANISOLE;4-Bromo-3-nitroanisole >4-bromo-3-nitrobenzyl ether;3-nitro-4-bromobenzyl ether;4-Methoxy-2-nitrobromobenzene
- CBNumber
- CB8211332
- Molecular Formula
- C7H6BrNO3
- Formula Weight
- 232.03
- MOL File
- 5344-78-5.mol
4-Bromo-3-nitroanisole Property
- Melting point:
- 32-34 °C (lit.)
- Boiling point:
- 153-154 °C/13 mmHg (lit.)
- Density
- 1.8134 (rough estimate)
- refractive index
- 1.6090 (estimate)
- Flash point:
- >230 °F
- storage temp.
- Keep in dark place,Inert atmosphere,Room temperature
- form
- powder to lump to clear liquid
- color
- White or Colorles to Yellow to Orange
- BRN
- 2446617
- InChI
- InChI=1S/C7H6BrNO3/c1-12-5-2-3-6(8)7(4-5)9(10)11/h2-4H,1H3
- InChIKey
- KCOBIBRGPCFIGF-UHFFFAOYSA-N
- SMILES
- C1(Br)=CC=C(OC)C=C1[N+]([O-])=O
- CAS DataBase Reference
- 5344-78-5(CAS DataBase Reference)
- NIST Chemistry Reference
- 4-Bromo-3-nitroanisole(5344-78-5)
Safety
- Hazard Codes
- Xi
- Risk Statements
- 36/37/38
- Safety Statements
- 26-36-24/25
- WGK Germany
- 3
- HS Code
- 29093090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- 338737
- Product name
- 4-Bromo-3-nitroanisole
- Purity
- 97%
- Packaging
- 5g
- Price
- $31
- Updated
- 2025/07/31
- Product number
- B3420
- Product name
- 4-Bromo-3-nitroanisole
- Purity
- >96.0%(GC)
- Packaging
- 5g
- Price
- $39
- Updated
- 2025/07/31
- Product number
- B3420
- Product name
- 4-Bromo-3-nitroanisole
- Purity
- >96.0%(GC)
- Packaging
- 25g
- Price
- $127
- Updated
- 2025/07/31
- Product number
- B688138
- Product name
- 4-Bromo-3-nitroanisole
- Packaging
- 5g
- Price
- $75
- Updated
- 2021/12/16
- Product number
- CS-W008002
- Product name
- 1-Bromo-4-methoxy-2-nitrobenzene
- Packaging
- 25g
- Price
- $30
- Updated
- 2021/12/16
4-Bromo-3-nitroanisole Chemical Properties,Usage,Production
Chemical Properties
Yellow to dark brown solid
Uses
4-Bromo-3-nitroanisole was used in the synthesis of:
- 4-bromo-5-methoxyaniline
- 2-(4-methoxy-2-nitrophenylsulfanyl)benzoic acid
- 4-(1-diethylamino-4-pentylamino)-3-nitrochlorobenzene
General Description
FT-IR and FT-Raman spectra of 4-bromo-3-nitroanisole have been studied.
Synthesis
96-96-8
5344-78-5
The general procedure for the synthesis of 4-bromo-3-nitroanisole from ice-dyed diazo component 1 was as follows: a solution of sodium nitrite (11.8 g) in water (28 mL) was slowly added dropwise to a 40% solution of nitroaniline (125 mmol) in hydrobromic acid (110 g) over a period of 0.5 h. The temperature of the reaction was maintained at 10 °C. The reaction mixture was stirred at 0-10 °C for 40 min and then filtered. Subsequently, the filtrate was added dropwise to a purple solution of copper(I) bromide (209 mmol) in hydrobromic acid (74 mL) at 0 °C over a period of 1 hour. The reaction mixture was gradually warmed to room temperature and held for 30 min, then warmed to 60 °C for 0.5 h. The reaction was finally heated and refluxed for 1 h. The reaction was carried out at a temperature of 0.5 °F to 0.5 °F. After completion of the reaction, the mixture was partitioned between water (2.0 L) and dichloromethane (600 mL) and the aqueous phase was then extracted with dichloromethane (300 mL). All organic layers were combined and washed sequentially with 10% sodium hydroxide solution (200 mL), water (600 mL), 10% hydrochloric acid (300 mL) and water (600 mL). The organic layer was dried over magnesium sulfate and concentrated to give 4-bromo-3-nitroanisole in 83% yield as a yellow oil.
References
[1] Journal of Organic Chemistry, 1989, vol. 54, # 25, p. 5856 - 5866
[2] Journal of Organic Chemistry, 1992, vol. 57, # 24, p. 6380 - 6382
[3] Journal of the American Chemical Society, 1994, vol. 116, # 26, p. 11797 - 11810
[4] Tetrahedron Letters, 2006, vol. 47, # 16, p. 2739 - 2742
[5] Tetrahedron, 2010, vol. 66, # 37, p. 7418 - 7422
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Raw materials
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View Lastest Price from 4-Bromo-3-nitroanisole manufacturers
- Product
- 4-Bromo-3-Nitroanisole 5344-78-5
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 1
- Release date
- 2025-08-25
- Product
- 4-Bromo-3-nitroanisole 5344-78-5
- Price
- US $0.00/KG
- Min. Order
- 25KG
- Purity
- 98%min
- Supply Ability
- 30tons/month
- Release date
- 2023-01-12
- Product
- 4-Bromo-3-nitroanisole 5344-78-5
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 1ton
- Release date
- 2022-09-30