Cefotetan disodium

ChemicalBook > CAS DataBase List > Cefotetan disodium

Brand Name(s) in US

Product Name: Cefotetan disodium
CAS No.: 74356-00-6
Chemical Name: Cefotetan disodium
Synonyms: Cefotan in plastic container;Cefotetan and dextrose in duplex container;Cefotetan disodi;CEFOTETAN DISODIUM;Ondansetron Impurity 14;Cefotetan DisodiuM Sterile;Cefotetan Sodium (ICI156834;Cefotetan disodium USP/EP/BP;Disodium (7R)-7-[[4-(carbamoyl-carboxylato-methylidene)-1,3-dithietane-2-carbonyl]amino]-7-methoxy-3-[(1-methyltetrazol-5-yl)sulfanylmethyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate;5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylicacid,7-[[[4-(2-aMino-1-carboxy-2-oxoethylidene)-1,3-dithietan-2-yl]carbonyl]aMino]-7-Methoxy-3-[[(1-Methyl-1H-tetrazol-5-yl)thio]Methyl]-8-oxo-,sodiuM salt (1:2), (6R,7S)-
CBNumber: CB82130367
Molecular Formula: C17H18N7NaO8S4
Formula Weight: 599.6
MOL File: 74356-00-6.mol

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Cefotetan disodium Property

Boiling point:: 798℃
RTECS: XI0330600
storage temp.: 2-8°C
solubility: Freely soluble in aqueous solution
form: powder

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Safety

Hazard Codes: Xn
Risk Statements: 20/21/22-36/37/38
Safety Statements: 26-36
WGK Germany: 3
HS Code: 29419000
Toxicity: LD50 in male mice, rats (g/kg): 6.35, 8.48 i.v.; 8.12, 8.37 i.p.; >10 orally and s.c. both species (Imamura)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H317May cause an allergic skin reaction

H334May cause allergy or asthma symptoms or breathing difficulties if inhaled

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P284Wear respiratory protection.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: A5737
Product name: Cefotetan disodium
Packaging: 100mg
Price: $47.6
Updated: 2024/03/01

Alfa Aesar

Product number: J66206
Product name: Cefotetan disodium
Packaging: 100mg
Price: $89.65
Updated: 2024/03/01

Cayman Chemical

Product number: 23624
Product name: Cefotetan (sodium salt)
Purity: ≥98%
Packaging: 50mg
Price: $64
Updated: 2024/03/01

Cayman Chemical

Product number: 23624
Product name: Cefotetan (sodium salt)
Purity: ≥98%
Packaging: 100mg
Price: $101
Updated: 2024/03/01

Cayman Chemical

Product number: 23624
Product name: Cefotetan (sodium salt)
Purity: ≥98%
Packaging: 250mg
Price: $236
Updated: 2024/03/01

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Cefotetan disodium Chemical Properties,Usage,Production

Brand Name(s) in US

Cefotan

Description

Cefotetan disodium is a β-lactamase resistant, second generation cephalosporin with a serum half-life of about three hours, permitting twice-daily dosing.

Originator

Yamanouchi (Japan)

Uses

Cefotetan Disodium is a related compound of Cefotetan (C242970), an antibiotic related to Cephalosporin that is used to treat bacterial infections.

Uses

Antibacterial.

Definition

ChEBI: The disodium salt of cefotetan.

brand name

Cefotan (AstraZeneca);YAMATETAN.

Clinical Use

Cefotetan (Cefotan) is a third-generation cephalosporin thatis structurally similar to cefoxitin. Like cefoxitin, cefotetanis resistant to destruction by β-lactamases. It is also a competitiveinhibitor of many β-lactamases and causes transient inactivation of some of these enzymes. Cefotetan is reportedto synergize with β-lactamase–sensitive β-lactams but, unlikecefoxitin, does not appear to cause antagonism.
The antibacterial spectrum of cefotetan closely resemblesthat of cefoxitin. It is, however, generally more activeagainst S. aureus, and members of the Enterobacteriaceaefamily sensitive to both agents. It also exhibits excellentpotency against H. influenzae and N. gonorrhoeae, includingβ-lactamase–producing strains. Cefotetan is slightly lessactive than cefoxitin against B. fragilis and other anaerobes.Enterobacter spp. are generally resistant to cefotetan, andthe drug is without effect against Pseudomonas spp.Cefotetan has a relatively long half-life of about 3.5hours. It is administered on a twice-daily dosing schedule. Itis excreted largely unchanged in the urine. Aqueoussolutions for parenteral administration maintain potency for24 hours at 25°C. Refrigerated solutions are stable for 4 days.
Cefotetan contains the MTT group that has been associatedwith hypoprothrombinemia and alcohol intolerance.Another cephalosporin that lacks these properties should beselected for patients at risk for severe bleeding or alcoholism.

Veterinary Drugs and Treatments

Cefotetan may be a reasonable choice for treating serious infections caused by susceptible bacteria, including E. coli or anaerobes. It appears to be well tolerated in small animals and may be given less frequently than cefoxitin.

Cefotetan disodium Preparation Products And Raw materials

Raw materials

Preparation Products

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Cefotetan disodium Suppliers

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View Lastest Price from Cefotetan disodium manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD

Product: Cefotetan disodium 74356-00-6
Price: US $0.00/Kg/Bag
Min. Order: 1KG
Purity: 98%min
Supply Ability: 500kg
Release date: 2021-11-03

Shaanxi Dideu Medichem Co. Ltd

Product: Cefotetan disodium 74356-00-6
Price: US $0.00-0.00/Kg
Min. Order: 1KG
Purity: 99.0%+
Supply Ability: 300 MT
Release date: 2020-05-23

Career Henan Chemical Co

Product: Cefotetan disodium 74356-00-6
Price: US $1.00/g
Min. Order: 100g
Purity: 99%
Supply Ability: G/KG/T
Release date: 2019-12-20

74356-00-6, Cefotetan disodiumRelated Search:

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5-Thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic acid, 7-(((4-(2-amino-1-carboxy-2-oxoethylidene)-1,3-dithietan-2-yl)carbonyl)amino)-7-methoxy-3-(((1-methyl-1H-tetrazol-5-yl)thio)methyl)-8-oxo-, disodium salt, (6R-(6alpha,7alpha))-

Cefotan in plastic container

CEFOTETAN DISODIUM

Disodium (7R)-7-[[4-(carbamoyl-carboxylato-methylidene)-1,3-dithietane-2-carbonyl]amino]-7-methoxy-3-[(1-methyltetrazol-5-yl)sulfanylmethyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate

Cefotetan and dextrose in duplex container

5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylicacid,7-[[[4-(2-aMino-1-carboxy-2-oxoethylidene)-1,3-dithietan-2-yl]carbonyl]aMino]-7-Methoxy-3-[[(1-Methyl-1H-tetrazol-5-yl)thio]Methyl]-8-oxo-,sodiuM salt (1:2), (6R,7S)-

Cefotetan disodi

Cefotetan DisodiuM Sterile

Cefotetan disodium USP/EP/BP

Cefotetan Sodium (ICI156834

Ondansetron Impurity 14

74356-00-6