Cefotetan disodium
Brand Name(s) in US- Product Name
- Cefotetan disodium
- CAS No.
- 74356-00-6
- Chemical Name
- Cefotetan disodium
- Synonyms
- Cefotan in plastic container;Cefotetan and dextrose in duplex container;Cefotetan disodi;CEFOTETAN DISODIUM;Ondansetron Impurity 14;Cefotetan DisodiuM Sterile;Cefotetan Sodium (ICI156834;Cefotetan disodium USP/EP/BP;Disodium (7R)-7-[[4-(carbamoyl-carboxylato-methylidene)-1,3-dithietane-2-carbonyl]amino]-7-methoxy-3-[(1-methyltetrazol-5-yl)sulfanylmethyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate;5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylicacid,7-[[[4-(2-aMino-1-carboxy-2-oxoethylidene)-1,3-dithietan-2-yl]carbonyl]aMino]-7-Methoxy-3-[[(1-Methyl-1H-tetrazol-5-yl)thio]Methyl]-8-oxo-,sodiuM salt (1:2), (6R,7S)-
- CBNumber
- CB82130367
- Molecular Formula
- C17H18N7NaO8S4
- Formula Weight
- 599.6
- MOL File
- 74356-00-6.mol
Cefotetan disodium Property
- Boiling point:
- 798℃
- RTECS
- XI0330600
- storage temp.
- 2-8°C
- solubility
- Freely soluble in aqueous solution
- form
- powder
Safety
- Hazard Codes
- Xn
- Risk Statements
- 20/21/22-36/37/38
- Safety Statements
- 26-36
- WGK Germany
- 3
- HS Code
- 29419000
- Toxicity
- LD50 in male mice, rats (g/kg): 6.35, 8.48 i.v.; 8.12, 8.37 i.p.; >10 orally and s.c. both species (Imamura)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H317May cause an allergic skin reaction
H334May cause allergy or asthma symptoms or breathing difficulties if inhaled
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P284Wear respiratory protection.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
N-Bromosuccinimide Price
- Product number
- A5737
- Product name
- Cefotetan disodium
- Packaging
- 100mg
- Price
- $47.6
- Updated
- 2024/03/01
- Product number
- J66206
- Product name
- Cefotetan disodium
- Packaging
- 100mg
- Price
- $89.65
- Updated
- 2024/03/01
- Product number
- 23624
- Product name
- Cefotetan (sodium salt)
- Purity
- ≥98%
- Packaging
- 50mg
- Price
- $64
- Updated
- 2024/03/01
- Product number
- 23624
- Product name
- Cefotetan (sodium salt)
- Purity
- ≥98%
- Packaging
- 100mg
- Price
- $101
- Updated
- 2024/03/01
- Product number
- 23624
- Product name
- Cefotetan (sodium salt)
- Purity
- ≥98%
- Packaging
- 250mg
- Price
- $236
- Updated
- 2024/03/01
Cefotetan disodium Chemical Properties,Usage,Production
Brand Name(s) in US
Cefotan
Description
Cefotetan disodium is a β-lactamase resistant, second generation cephalosporin with a serum half-life of about three hours, permitting twice-daily dosing.
Originator
Yamanouchi (Japan)
Uses
Cefotetan Disodium is a related compound of Cefotetan (C242970), an antibiotic related to Cephalosporin that is used to treat bacterial infections.
Uses
Antibacterial.
Definition
ChEBI: The disodium salt of cefotetan.
brand name
Cefotan (AstraZeneca);YAMATETAN.
Clinical Use
Cefotetan (Cefotan) is a third-generation cephalosporin thatis structurally similar to cefoxitin. Like cefoxitin, cefotetanis resistant to destruction by β-lactamases. It is also a competitiveinhibitor of many β-lactamases and causes transient inactivation of some of these enzymes. Cefotetan is reportedto synergize with β-lactamase–sensitive β-lactams but, unlikecefoxitin, does not appear to cause antagonism.
The antibacterial spectrum of cefotetan closely resemblesthat of cefoxitin. It is, however, generally more activeagainst S. aureus, and members of the Enterobacteriaceaefamily sensitive to both agents. It also exhibits excellentpotency against H. influenzae and N. gonorrhoeae, includingβ-lactamase–producing strains. Cefotetan is slightly lessactive than cefoxitin against B. fragilis and other anaerobes.Enterobacter spp. are generally resistant to cefotetan, andthe drug is without effect against Pseudomonas spp.Cefotetan has a relatively long half-life of about 3.5hours. It is administered on a twice-daily dosing schedule. Itis excreted largely unchanged in the urine. Aqueoussolutions for parenteral administration maintain potency for24 hours at 25°C. Refrigerated solutions are stable for 4 days.
Cefotetan contains the MTT group that has been associatedwith hypoprothrombinemia and alcohol intolerance.Another cephalosporin that lacks these properties should beselected for patients at risk for severe bleeding or alcoholism.
Veterinary Drugs and Treatments
Cefotetan may be a reasonable choice for treating serious infections caused by susceptible bacteria, including E. coli or anaerobes. It appears to be well tolerated in small animals and may be given less frequently than cefoxitin.
Cefotetan disodium Preparation Products And Raw materials
Raw materials
Preparation Products
Cefotetan disodium Suppliers
- Tel
- --
- Fax
- --
- Country
- Europe
- ProdList
- 1780
- Advantage
- 38
View Lastest Price from Cefotetan disodium manufacturers
- Product
- Cefotetan disodium 74356-00-6
- Price
- US $0.00/Kg/Bag
- Min. Order
- 1KG
- Purity
- 98%min
- Supply Ability
- 500kg
- Release date
- 2021-11-03
- Product
- Cefotetan disodium 74356-00-6
- Price
- US $0.00-0.00/Kg
- Min. Order
- 1KG
- Purity
- 99.0%+
- Supply Ability
- 300 MT
- Release date
- 2020-05-23
- Product
- Cefotetan disodium 74356-00-6
- Price
- US $1.00/g
- Min. Order
- 100g
- Purity
- 99%
- Supply Ability
- G/KG/T
- Release date
- 2019-12-20