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Semicarbazide hydrochloride

Product Name
Semicarbazide hydrochloride
CAS No.
563-41-7
Chemical Name
Semicarbazide hydrochloride
Synonyms
SEM;SEMICARBAZIDE HCL;AMINOUREA HYDROCHLORIDE;SEM·HCl;SCA-HCl;SEMICARBAZIDE HYDROCHLORIDE REAGENT;HYDRAZINE CARBOXAMIDE MONOHYDROCHLORIDE;Semicarbaside;Semicarbazide-13C;15N2, 98%) 100 UG/
CBNumber
CB8213684
Molecular Formula
CH6ClN3O
Formula Weight
111.53
MOL File
563-41-7.mol
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Semicarbazide hydrochloride Property

Melting point:
175-177 °C (dec.)(lit.)
Boiling point:
394.09℃[at 101 325 Pa]
Density 
1.2908 (rough estimate)
vapor pressure 
0-0Pa at 25℃
refractive index 
1.4480 (estimate)
storage temp. 
Store at +15°C to +25°C.
solubility 
H2O: 0.1 g/mL at 20 °C, clear, colorless
form 
Crystalline Powder and/or Chunks
color 
White
PH
1.5 (100g/l, H2O, 20℃)
Water Solubility 
100 g/L (15 ºC)
Merck 
14,8444
BRN 
3593642
Stability:
Stable. Incompatible with strong oxidizing agents, strong bases.
InChIKey
XHQYBDSXTDXSHY-UHFFFAOYSA-N
LogP
-4.99--1.9 at 20℃
CAS DataBase Reference
563-41-7(CAS DataBase Reference)
IARC
3 (Vol. 12, Sup 7) 1987
EPA Substance Registry System
Semicarbazide hydrochloride (563-41-7)
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Safety

Hazard Codes 
Xn,T
Risk Statements 
22-40-36/38-25-45-23/24/25
Safety Statements 
24/25-22-45-53
RIDADR 
UN 2811 6.1/PG 3
WGK Germany 
3
RTECS 
VT3500000
TSCA 
Yes
HS Code 
2928 00 90
HazardClass 
6.1
PackingGroup 
III
Hazardous Substances Data
563-41-7(Hazardous Substances Data)
Toxicity
LD50 orally in Rabbit: 123 mg/kg
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H301Toxic if swalloed

H314Causes severe skin burns and eye damage

H373May cause damage to organs through prolonged or repeated exposure

Precautionary statements

P201Obtain special instructions before use.

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
8.18369
Product name
Semicarbazide hydrochloride
Purity
for synthesis
Packaging
100g
Price
$37.3
Updated
2024/03/01
Sigma-Aldrich
Product number
8.18369
Product name
Semicarbazide hydrochloride
Purity
for synthesis
Packaging
500g
Price
$173
Updated
2024/03/01
Sigma-Aldrich
Product number
33656
Product name
Semicarbazide hydrochloride
Purity
VETRANAL?, analytical standard
Packaging
100mg
Price
$89.6
Updated
2024/03/01
Sigma-Aldrich
Product number
84940
Product name
Semicarbazide hydrochloride
Purity
purum p.a., ≥98.0% (AT)
Packaging
100g
Price
$46.5
Updated
2022/05/15
TCI Chemical
Product number
S0032
Product name
Semicarbazide Hydrochloride
Purity
>99.0%(T)
Packaging
25g
Price
$21
Updated
2024/03/01
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Semicarbazide hydrochloride Chemical Properties,Usage,Production

Chemical Properties

White Solid

Chemical Properties

Semicarbazide hydrochloride is a white crystalline solid.

Uses

Inhibitor of enzyme. Hypotensive

Uses

A metabolite of Nitrofuran.

Uses

Semicarbazide hydrochloride is used as urease substrate and MAO inhibitor. Derivatizing agent for carbonyl compounds as their semicarbazones which produces crystalline compounds with characteristic melting points. Also used in heterocyclic synthesis. Semicarbazone formation has been used to separate carbonyl compounds from mixtures by adsorption onto silica gel from a hydrocarbon solution. Regeneration is by hydrolysis with oxalic acid.

Definition

ChEBI: Semicarbazide hydrochloride is an organic molecular entity.

Hazard

Toxic by ingestion. Questionable carcino- gen.

Health Hazard

Semicarbazide hydrochloride is a chemical reagent, and an indicator for its metabolic parent nitrofurazone, a veterinary drug that has been banned for use in livestock production in the European Union and the U.S. amongst other jurisdictions.
After Semicarbazide hydrochloride ingestion, experimental animals have developed tremors, ataxia, equilibrium difficulties, and convulsions. Its proposed mechanism of action is by binding to cytosine residues in RNA, to deoxycytosine residues in DNA and to cytosine and deoxycytosine nucleosides.
Semicarbazide hydrochloride has an oral LD50 of 225mg/kg in mice and 123 mg/kg in the rat. Some studies suggest that Semicarbazide hydrochloride is a mutagen, an animal carcinogen and a teratogen.
Due to the lack of data in humans and overall limited evidence of carcinogenicity in animals, semicarbazide hydrochloride was classified as an IARC Group 3 agent: not classifiable as to its carcinogenicity to humans. Due to its equivocal carcinogenic and mutagenic properties, when handling Semicarbazide hydrochloride and animals treated with Semicarbazide hydrochloride, it is imperative to take caution and adhere to the following guidelines to minimize exposure and the effects of exposure during normal and emergency situations.

Flammability and Explosibility

Not classified

Safety Profile

Poison by ingestion and intraperitoneal routes. Experimental reproductive effects. Questionable carcinogen with experimental neoplastigenic and teratogenic data. Mutation data reported. When heated to decomposition it emits very toxic fumes of NOx and HCl

Potential Exposure

This material is used as a reagent for ketones and aldehydes with which it affords crystalline compounds having characteristic freezing/melting points. Also used in isolation of hormones and certain fractions from essential oils.

Shipping

UN2811 Toxic solids, organic, n.o.s., Hazard Class: 6.1; Labels: 6.1-Poisonous materials, Technical Name Required.

Purification Methods

Crystallise the salt from aqueous 75% EtOH and dry it under vacuum over CaSO4. Alternatively crystallise it from a mixture of 3.6 mole % MeOH and 6.4 mole % of water. [Kovach et al. J Am Chem Soc 107 7360 1985.] IR: 700, 3500 cm-1 [Ingersoll et al. Org Synth Coll Vol I 485 1941, Davison & Christie J Chem Soc 3389 1955, Thiele & Stange Chem Ber 27 33 1894, pK: Bartlett J Am Chem Soc 54 2853 1923]. The free base crystallises as prisms from absolute EtOH, m 96o. [Curtius & Heidenreich Chem Ber 27 55 1894, Beilstein 3 IV 177.] TOXIC ORALLY, possible CARCINOGEN and TERATOGEN.

Incompatibilities

Incompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explosions. Keep away from alkaline materials, strong bases, strong acids, oxoacids, epoxides. May ignite combustible materials (wood, oil, paper).

Semicarbazide hydrochloride Preparation Products And Raw materials

Raw materials

Hydrazinium hydroxide solution Hydrazine hydrate Semicarbazide

Preparation Products

4,5-Dichloro-3(2H)-pyridazinone 3-PHENYL-1H-PYRAZOLE-4-CARBALDEHYDE 6-AZATHYMINE ETHYL 4-PHENYL-1,2,3-THIADIAZOLE-5-CARBOXYLATE 3-Amino-5-phenylpyrazole Semicarbazide 4-CHLORO-2-(TETRAHYDRO-2H-PYRAN-2-YL)-5-HYDROXYPYRIDAZIN-3(2H)-ONE 5-CHLORO-4-(CHLOROMETHYL)-1,2,3-THIADIAZOLE, 97%, 97 3-(4-FLUOROPHENYL)-1H-PYRAZOLE-4-CARBALDEHYDE
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View Lastest Price from Semicarbazide hydrochloride manufacturers

Hebei Zhuanglai Chemical Trading Co.,Ltd
Product
Semicarbazide HCl 563-41-7
Price
US $180.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
20ton
Release date
2024-06-05
Hebei Chuanghai Biotechnology Co,.LTD
Product
Semicarbazide hydrochloride 563-41-7
Price
US $1.90/KG
Min. Order
1KG
Purity
99%
Supply Ability
10 ton
Release date
2024-08-20
Henan Bao Enluo International TradeCo.，LTD
Product
Semicarbazide hydrochloride 563-41-7
Price
US $100.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
500t/month
Release date
2023-07-25

563-41-7, Semicarbazide hydrochlorideRelated Search:

Semicarbazide Topotecan hydrochloride Acetaminophen HYDRAZINE D-Glucosamine hydrochloride Aminoacetonitrile hydrochloride AMINOGUANIDINE HYDROCHLORIDE EC 2.6.1.2 Lomustine Trazodone Carmustine 4-PHENYLSEMICARBAZIDE HYDROCHLORIDE Nitrofurazone CARBOXAMIDE 4-(4-CHLOROPHENYL)SEMICARBAZIDE HYDROCHLORIDE 4-(2-CHLOROPHENYL)SEMICARBAZIDE 4-(2-CHLOROPHENYL)SEMICARBAZIDE HYDROCHLORIDE 4-(4-METHYLPHENYLSULFONYL)SEMICARBAZIDE HYDROCHLORIDE Semicarbazide Hcl

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