N-BOC-4,4'-BIPIPERIDINE

Product Name: N-BOC-4,4'-BIPIPERIDINE
CAS No.: 171049-35-7
Chemical Name: N-BOC-4,4'-BIPIPERIDINE
Synonyms: tert-butyl 4-(piperidin-4-yl)piperidine-1-carboxylate;-bipiperidine;N-Boc-4,4’N-Boc-4,4'-bipiperidine;N-Boc-4,4'-Bipiperidine;1-Boc- 4,4\'-bipiperidine;4,4'-Bipiperidine, 1-BOC protected;N-Boc-4,4′-bipiperidine, CAS 171049-35-7;1-(tert-Butoxycarbonyl)-4,4'-bipiperidine;tert-Butyl 4,4'-bipiperidine-1-carboxylate
CBNumber: CB8221249
Molecular Formula: C15H28N2O2
Formula Weight: 268.39
MOL File: 171049-35-7.mol

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N-BOC-4,4'-BIPIPERIDINE Property

Boiling point:: 363℃
Density: 1.028
Flash point:: 173℃
storage temp.: 2-8°C(protect from light)
pka: 10.38±0.10(Predicted)
form: solid
color: Cream

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Safety

Hazard Codes: Xi
HazardClass: IRRITANT
HS Code: 2933399990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: B200895
Product name: N-Boc-4,4''-bipiperidine
Packaging: 250mg
Price: $95
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB51004
Product name: N-Boc-4,4'-bipiperidine
Packaging: 250mg
Price: $90
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB51004
Product name: N-Boc-4,4'-bipiperidine
Packaging: 2g
Price: $300
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB51004
Product name: N-Boc-4,4'-bipiperidine
Packaging: 500mg
Price: $120
Updated: 2021/12/16

Matrix Scientific

Product number: 045893
Product name: 4-(4'-Piperid-1-yl)-1-tert-butoxycarbonyl-piperidine
Purity: >95%
Packaging: 500mg
Price: $127
Updated: 2021/12/16

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N-BOC-4,4'-BIPIPERIDINE Chemical Properties,Usage,Production

Synthesis

24424-99-5

78619-84-8

171049-35-7

The general procedure for the synthesis of tert-butyl [4,4'-bipiperidinyl]-1-carboxylate from di-tert-butyl dicarbonate and 4,4'-bipiperidinium dihydrochloride is as follows: 1. prepare 4-(4-piperidinyl)-1-piperidine carboxylic acid, 1,1-dimethylethyl ester (LXXXIX). 2. dissolve 41 g (0.17 mol) of 4,4'-bipiperidine dihydrochloride in 250 mL of ethanol and 250 mL of 2N sodium hydroxide solution. 3. 18.5 g (0.085 mol) of tert-butyl dicarbonate was slowly added to a 100 mL ethanol solution at 0°C. 4. The reaction mixture was stirred at 10 °C for 1 hour. 5. The ethanol was removed using a rotary evaporator. 6. The residual aqueous phase was saturated with sodium chloride and extracted with ethyl acetate. 7. The organic phases were combined, dried with magnesium sulfate and concentrated under reduced pressure. 8. The crude product was purified by silica gel column chromatography, the eluent being a mixture of dichloromethane/methanol/ammonia (8:2:0.4, v/v). 9. 16.5 g of the target compound tert-butyl [4,4'-bipiperidine]-1-carboxylate was finally obtained as a white solid in 72% yield, with a melting point of 70-71°C. The product was purified by silica gel column chromatography.

References

[1] Patent: US2006/178360, 2006, A1. Location in patent: Page/Page column 17
[2] Patent: US6008213, 1999, A
[3] Journal of Medicinal Chemistry, 2016, vol. 59, # 7, p. 3489 - 3498
[4] Patent: WO2017/83219, 2017, A1. Location in patent: Page/Page column 43; 44

N-BOC-4,4'-BIPIPERIDINE Preparation Products And Raw materials

Raw materials

Preparation Products

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N-BOC-4,4'-BIPIPERIDINE Suppliers

Canada 1 China 63 Germany 2 India 1 Japan 1 Switzerland 1 United Kingdom 6 United States 16 Global 91

Alchem Pharmtech,Inc.

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View Lastest Price from N-BOC-4,4'-BIPIPERIDINE manufacturers

Career Henan Chemical Co

Product: N-BOC-4,4'-BIPIPERIDINE 171049-35-7
Price: US $0.01/KG
Min. Order: 500g
Purity: 98%; 99%
Supply Ability: 500g；1kg； 10kg; 25kg
Release date: 2020-01-08

171049-35-7, N-BOC-4,4'-BIPIPERIDINERelated Search:

N-BOC-2-(4-BROMO-PHENYL)-ETHYLAMINE N-BOC-4-PIPERIDINEACETALDEHYDE N-BOC-L-Arginine hydrochloride N-Boc-3-bromo-4-fluoroaniline N-Boc-2-piperidinecarboxylic acid N-Boc-3-Ethylpiperazine N-BOC-4,4-difluoro-L-proline N-Boc-5-amino-2-fluoropyridine 1-Boc-3-piperidinecarboxylic acid 1-Boc-3-hydroxypiperidine TERT-BUTYL 3-BROMOPHENETHYLCARBAMATE (3-IODO-PHENYL)-CARBAMIC ACID TERT-BUTYL ESTER 1-N-Boc-3-Methylpiperidine-3-carboxylic acid N-Boc-cis-2,6-Diethyl-4-piperidone N-BOC-DL-SERINE TERT-BUTYL 4-(3-AMINOPROPYL)PIPERIDINE-1-CARBOXYLATE N-BOC-4,4'-BIPIPERIDINE Tert-butyl 3-(piperidin-4-yl)propylcarbamate

[4,4']BIPIPERIDINYL-1-CARBOXYLIC ACID TERT-BUTYL ESTER

4-(4'-PIPERID-1-YL)-1-TERT-BUTOXYCARBONYL PIPERIDINE

N-(tert-Butoxycarbonyl)-4,4''-bipiperidine

tert-Butyl 4,4'-bipiperidine-1-carboxylate

tert-Butyl 4,4'-bipiperidine-1-carboxylate, 4-(tert-Butoxycarbonyl)-4-piperidin-4-ylpiperidine

[4,4'-Bipiperidine]-1-carboxylic acid 1,1-dimethylethyl ester

1-(tert-Butoxycarbonyl)-4,4'-bipiperidine

1,1-Dimethylethyl 4,4'-bipiperidine-1-carboxylate

4-(4-Piperidinyl)-1-piperidinecarboxylic acid 1,1-dimethylethyl ester

4,4'-Bipiperidine, 1-BOC protected

tert-Butyl 4,4'-bipiperidine-1-carboxylate, 1-(tert-Butoxycarbonyl)-4,4'-bipiperidine

tert-butyl 4-(piperidin-4-yl)piperidine-1-carboxylate

1-Boc- 4,4\'-bipiperidine

4-Piperidin-4-ylpiperidine, N-BOC protected

4-(1-piperidinyl)-1-piperidinecarboxylic acid tert-butyl ester

-bipiperidine

N-Boc-4,4&rsquo

N-Boc-4,4'-bipiperidine

tert-Butyl [4,4'-bipiperidine]-1-carboxylate

tert-butyl 4-(4-piperidyl)piperidine-1-carboxylate

4,4'Bipiperidinyl-1-carboxylic acid tert-butyl ester

N-Boc-4,4′-bipiperidine, CAS 171049-35-7

N-Boc-4,4'-Bipiperidine

171049-35-7

C15H28N2O2

pharmacetical