Ethyl 4-bromobenzoylformate
- Product Name
- Ethyl 4-bromobenzoylformate
- CAS No.
- 20201-26-7
- Chemical Name
- Ethyl 4-bromobenzoylformate
- Synonyms
- Ethyl 2-(4-bromophenyl)-2-oxoacetate;Ethyl p-bromophenylglyoxylate;ETHYL 4-BROMOBENZOYL FORMATE;ETHYL 4-BROMOPHENYLGLYOXYLATE;2-(4-bromophenyl)-2-oxoacetate;ETHYL 4-(BROMOPHENYL)GLYOXALATE;Ethyl (4-bromophenyl)(oxo)acetate;4-BROMOBENZOYLFORMICACIDETHYLESTER;Benzeneacetic acid, 4-bromo-α-oxo-, ethyl ester;BENZENEACETIC ACID, 4-BROMO-A-OXO-, ETHYL ESTER
- CBNumber
- CB8226350
- Molecular Formula
- C10H9BrO3
- Formula Weight
- 257.08
- MOL File
- 20201-26-7.mol
Ethyl 4-bromobenzoylformate Property
- Boiling point:
- 322°C
- Density
- 1.480
- Flash point:
- 149°C
- storage temp.
- Sealed in dry,Room Temperature
- Appearance
- Light yellow to yellow Liquid
Safety
- Hazard Codes
- Xi
- HS Code
- 2918999090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- E900993
- Product name
- Ethyl2-(4-Bromophenyl)-2-oxoacetate
- Packaging
- 100mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- 2629-9-05
- Product name
- Ethyl 4-bromophenylglyoxylate
- Packaging
- 250mg
- Price
- $120
- Updated
- 2021/12/16
- Product number
- 2629-9-05
- Product name
- Ethyl 4-bromophenylglyoxylate
- Packaging
- 1g
- Price
- $180
- Updated
- 2021/12/16
- Product number
- 086354
- Product name
- Ethyl 4-bromobenzoyl formate
- Purity
- 97%
- Packaging
- 1g
- Price
- $345
- Updated
- 2021/12/16
- Product number
- R021
- Product name
- Ethyl4-bromobenzoylformate
- Packaging
- 25g
- Price
- $490
- Updated
- 2021/12/16
Ethyl 4-bromobenzoylformate Chemical Properties,Usage,Production
Synthesis
108-86-1
4755-77-5
20201-26-7
To a stirred mixture of bromobenzene (0.7 mL, 6.5 mmol) and monoethyl oxalyl chloride (0.7 mL, 6.5 mmol) in dichloromethane (12 mL) was added aluminum trichloride (1.7 g, 12.5 mmol) in one batch. The reaction mixture was stirred at 0°C for 30 minutes before slowly warming to room temperature and continuing to stir for 18 hours. After completion of the reaction, the mixture was carefully poured into concentrated hydrochloric acid at 0°C to quench the reaction. Subsequently, the mixture was extracted with dichloromethane (3 × 100 mL). The organic layers were combined, washed with saturated saline (100 mL), dried over anhydrous sodium sulfate, filtered and concentrated under reduced pressure. The crude product was purified by silica gel column chromatography (eluent: ethyl acetate/petroleum ether = 1:20) to afford ethyl 4-bromophenylglyoxylate (1.0 g, 60% yield) as a yellow oil. Mass spectrometry (ESI+) analysis: C10H9BrO3 theoretical value [M+H]+ 256, measured value 257, 259 [M+H]+.
References
[1] Journal of Organic Chemistry, 1996, vol. 61, # 18, p. 6407 - 6415
[2] Tetrahedron Letters, 2006, vol. 47, # 16, p. 2675 - 2678
[3] Chemical Science, 2018, vol. 9, # 48, p. 8930 - 8936
[4] Patent: US2016/31892, 2016, A1. Location in patent: Paragraph 0156-0158
[5] Journal of Organic Chemistry, 2008, vol. 73, # 10, p. 3842 - 3847
Ethyl 4-bromobenzoylformate Preparation Products And Raw materials
Raw materials
Preparation Products
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