ChemicalBook > CAS DataBase List > 5-Chloro-2-cyanopyridine

5-Chloro-2-cyanopyridine

Product Name
5-Chloro-2-cyanopyridine
CAS No.
89809-64-3
Chemical Name
5-Chloro-2-cyanopyridine
Synonyms
5-chloropicolinonitrile;5-CHLOROPYRIDINE-2-CARBONITRILE;5-Chloro-2-cyanopyrid;6-CYANO-3-CHLOROPYRIDINE;5-CHLORO-2-CYANOPYRIDINE;3-Chloro-6-cyanopyridine;oropyridine-2-carbonitriL;5-Chloro-2-cyanopyridine94%;5-Chloro-2-cyanopyridine >5-Chloro-2-pyridinecarbonitrile
CBNumber
CB8242873
Molecular Formula
C6H3ClN2
Formula Weight
138.55
MOL File
89809-64-3.mol
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5-Chloro-2-cyanopyridine Property

Melting point:
106-108℃
Boiling point:
110°C/3mmHg(lit.)
Density 
1.33±0.1 g/cm3(Predicted)
storage temp. 
Inert atmosphere,Room Temperature
solubility 
Methanol
form 
Solid
pka
-2.60±0.10(Predicted)
color 
Yellow Cyrstalline
CAS DataBase Reference
89809-64-3(CAS DataBase Reference)
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Safety

Hazard Codes 
T,Xi
Risk Statements 
36/37/38
Safety Statements 
26-36
RIDADR 
UN 3439 6.1/PG III
Hazard Note 
Toxic
HazardClass 
IRRITANT
HazardClass 
6.1
PackingGroup 
III
HS Code 
29333990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H302Harmful if swallowed

H312Harmful in contact with skin

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

TCI Chemical
Product number
C3023
Product name
5-Chloro-2-cyanopyridine
Purity
>98.0%(GC)
Packaging
5g
Price
$122
Updated
2025/07/31
TCI Chemical
Product number
C3023
Product name
5-Chloro-2-cyanopyridine
Purity
>98.0%(GC)
Packaging
25g
Price
$408
Updated
2025/07/31
TRC
Product number
C962510
Product name
6-Cyano-3-chloropyridine
Packaging
25g
Price
$265
Updated
2021/12/16
Matrix Scientific
Product number
011186
Product name
5-Chloro-2-cyanopyridine
Purity
95%
Packaging
5g
Price
$23
Updated
2021/12/16
Apolloscientific
Product number
OR11381
Product name
5-Chloropyridine-2-carbonitrile
Purity
96%
Packaging
5g
Price
$25
Updated
2021/12/16
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5-Chloro-2-cyanopyridine Chemical Properties,Usage,Production

Chemical Properties

Light yellow Cryst

Uses

6-Cyano-3-chloropyridine (cas# 89809-64-3) is a compound useful in organic synthesis.

Synthesis

16110-09-1

557-21-1

89809-64-3

General procedure for the synthesis of 5-chloro-2-cyanopyridine from 2,5-dichloropyridine and zinc cyanide: In a 22-liter three-necked round-bottomed flask equipped with an overhead stirrer, a reflux condenser, and a thermometer, N,N-dimethylacetamide (DMAC, 6 L), 2,5-dichloropyridine (347.0 g, 2.34 mol), zinc cyanide (138.0 g, 1.17 mol ), bis(diphenylphosphino)dipalladium II CH2Cl2 complex (DPPF, 20.8 g, 0.02 mol) and zinc powder (1.6 g, 0.02 mol). The reaction mixture was slowly heated to 160 °C. When the temperature reaches 160°C, controlled exotherm may occur and the internal temperature may rise to 180-185°C. Remove the heat source and slowly cool the mixture to room temperature. Dilute the dark reaction mixture with 2L of water, add brine (2L), filter with diatomaceous earth and extract with ethyl acetate (4L). The process was repeated 3 times to ensure complete extraction, the organic phases were combined and dried with magnesium sulfate. Careful concentration at 25-30°C may give a dark colored liquid. (Note: the product may volatilize at higher temperatures, so keep the temperature low during concentration.) Add water (5L) to the concentrate, stir for 1 hour to precipitate a solid, filter, and wash the filter cake with 2L of water. The filter cake was dried to give 215 g of crude product. The aqueous filtrate was extracted with ether (8 L) and the organic phase was dried with magnesium sulfate and concentrated to give 51 g of crude product. The two batches of crude product were combined and purified by silica gel chromatography (Biotage 150; eluting first with 5% ethyl acetate/hexane and then 10% ethyl acetate/hexane) to give pure 5-chloro-2-cyanopyridine as a white solid (193 g, 59% yield).1H NMR (CDCl3) δ 8.68 (d, J = 2.0 Hz, 1H), 7.84 (dd , J = 2.7,8.6Hz, 1H), 7.66 (d, J = 8.3Hz, 1H).

References

[1] Patent: WO2005/66126, 2005, A1. Location in patent: Page/Page column 74-75

5-Chloro-2-cyanopyridine Preparation Products And Raw materials

Raw materials

Preparation Products

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5-Chloro-2-cyanopyridine Suppliers

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View Lastest Price from 5-Chloro-2-cyanopyridine manufacturers

Shaanxi Dideu New Materials Co. Ltd
Product
5-Chloro-2-cyanopyridine 89809-64-3
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
98.0%
Supply Ability
10000KGS
Release date
2025-05-30
Shaanxi Dideu Medichem Co. Ltd
Product
5-Chloro-2-cyanopyridine 89809-64-3
Price
US $1.10/g
Min. Order
1g
Purity
99.0% min
Supply Ability
100 tons mini
Release date
2021-05-12
Henan Fengda Chemical Co., Ltd
Product
5-Chloro-2-cyanopyridine 89809-64-3
Price
US $5.00-0.10/KG
Min. Order
1KG
Purity
98%
Supply Ability
g-kg-tons, free sample is available
Release date
2024-04-08

89809-64-3, 5-Chloro-2-cyanopyridineRelated Search:

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