2,4-DICHLOROFURO[3,2-D]PYRIMIDINE
- Product Name
- 2,4-DICHLOROFURO[3,2-D]PYRIMIDINE
- CAS No.
- 956034-07-4
- Chemical Name
- 2,4-DICHLOROFURO[3,2-D]PYRIMIDINE
- Synonyms
- 4-dichlorofuro[3;2,4-Dichlorofuro[3,2-d]py...;2,4-DICHLOROFURO[3,2-D]PYRIMIDINE;Furo[3,2-d]pyrimidine, 2,4-dichloro-;2,4-dichlorofurano [3,2-d] pyrimidine
- CBNumber
- CB82459156
- Molecular Formula
- C6H2Cl2N2O
- Formula Weight
- 189
- MOL File
- 956034-07-4.mol
2,4-DICHLOROFURO[3,2-D]PYRIMIDINE Property
- Density
- 1.619±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- pka
- -1.02±0.40(Predicted)
- Appearance
- Light yellow to brown Solid
- InChI
- InChI=1S/C6H2Cl2N2O/c7-5-4-3(1-2-11-4)9-6(8)10-5/h1-2H
- InChIKey
- OTFDNOQBJWBJJM-UHFFFAOYSA-N
- SMILES
- C1(Cl)=NC(Cl)=C2OC=CC2=N1
Safety
- HS Code
- 2934999090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H226Flammable liquid and vapour
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P233Keep container tightly closed.
P240Ground/bond container and receiving equipment.
P241Use explosion-proof electrical/ventilating/lighting/…/equipment.
P242Use only non-sparking tools.
P243Take precautionary measures against static discharge.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
P370+P378In case of fire: Use … for extinction.
P403+P235Store in a well-ventilated place. Keep cool.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- D434555
- Product name
- 2,4-Dichlorofuro[3,2-d]pyrimidine
- Packaging
- 100mg
- Price
- $165
- Updated
- 2021/12/16
- Product number
- FD21675
- Product name
- 2,4-Dichlorofuro[3,2-d]pyrimidine
- Packaging
- 250mg
- Price
- $175
- Updated
- 2021/12/16
- Product number
- FD21675
- Product name
- 2,4-Dichlorofuro[3,2-d]pyrimidine
- Packaging
- 100mg
- Price
- $100
- Updated
- 2021/12/16
- Product number
- W9757
- Product name
- 2,4-Dichlorofuro[3,2-d]pyrimidine
- Packaging
- 250mg
- Price
- $131
- Updated
- 2021/12/16
- Product number
- OR926903
- Product name
- 2,4-Dichlorofuro[3,2-d]pyrimidine
- Purity
- 95%
- Packaging
- 100mg
- Price
- $145
- Updated
- 2021/12/16
2,4-DICHLOROFURO[3,2-D]PYRIMIDINE Chemical Properties,Usage,Production
Uses
2,4-Dichlorofuro[3,2-d]pyrimidine is a furopyrimidine derivative used in the preparation of phosphoinositide 3-kinase inhibitor.
Synthesis
956034-06-3
956034-07-4
Furo[3,2-d]pyrimidine-2,4-diol (7J) (1.52 g, 10 mmol) was added to N,N-dimethylaniline (1 mL, 8 mmol) and trichlorophosphorus (0.9 mL, 9.65 mmol) as a starting material and the reaction was carried out for 3 hours at 130°C. The reaction was carried out at 130°C for 3 hours. Upon completion of the reaction, the mixture was cooled to room temperature and carefully quenched with ice water. The resulting solid product was collected by filtration, washed with water and dried under vacuum to afford 2,4-dichlorofuro[3,2-d]pyrimidine (7K) (1.02 g, 54% yield) as a light brown solid. The melting point of the product was 107.3°C. The NMR hydrogen spectrum (300 MHz, CDCl3) data were as follows: δ 8.08 (d, J = 2.2 Hz, 1H), 7.02 (d, J = 2.2 Hz, 1H).
References
[1] Patent: WO2011/79230, 2011, A2. Location in patent: Page/Page column 57
[2] Patent: US2008/76758, 2008, A1. Location in patent: Page/Page column 78
[3] Patent: WO2008/70740, 2008, A1. Location in patent: Page/Page column 138
[4] Patent: WO2008/73785, 2008, A2. Location in patent: Page/Page column 165
[5] Journal of Medicinal Chemistry, 2011, vol. 54, # 22, p. 7815 - 7833
2,4-DICHLOROFURO[3,2-D]PYRIMIDINE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2,4-DICHLOROFURO[3,2-D]PYRIMIDINE manufacturers
- Product
- 2,4-Dichlorofuro[3,2-d]pyriMidine 956034-07-4
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 20T
- Release date
- 2020-05-15
- Product
- 2,4-DICHLOROFURO[3,2-D]PYRIMIDINE 956034-07-4
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 200kg
- Release date
- 2020-01-03