Pemetrexed Disodium Heptahydrate

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Pemetrexed Disodium Heptahydrate

Product Name: Pemetrexed Disodium Heptahydrate
CAS No.: 357166-29-1
Chemical Name: Pemetrexed Disodium Heptahydrate
Synonyms: CS-248;Pemetrexed disodium(7HO);7-dihydro-4-oxo-3H-pyrrolo[2;PeMetrexed disodiuM 7-hydrate;Pemetrexed Disodium (1500659);Pemetrexed disodium hepthydrate;Pemetrexed (sodium salt hydrate);Pemetrexed for system suitability;Pemetrexed disodium 7 hydrate (CEP);Pemetrexed disodium heptahydrate CRS
CBNumber: CB82509918
Molecular Formula: C20H24N5NaO7
Formula Weight: 469.43
MOL File: 357166-29-1.mol

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Pemetrexed Disodium Heptahydrate Property

storage temp.: 2-8°C
solubility: H2O: soluble30mg/mL, clear
form: powder
color: white to beige
Stability:: Stable for 1 year as supplied. Solutions in distilled water may be stored at -20° for up to 31month.
InChI: InChI=1/C20H21N5O6.Na.H2O.H/c21-20-24-16-15(18(29)25-20)12(9-22-16)6-3-10-1-4-11(5-2-10)17(28)23-13(19(30)31)7-8-14(26)27;;;/h1-2,4-5,9,13H,3,6-8H2,(H,23,28)(H,26,27)(H,30,31)(H4,21,22,24,25,29);;1H2;/t13-;;;/s3
InChIKey: AEZRDYKQLPDYEH-YTCXBBKHNA-N
SMILES: C(C1=CNC2NC(N)=NC(=O)C1=2)CC1C=CC(C(=O)N[C@H](C(=O)O)CCC(=O)O)=CC=1.[NaH].O |&1:20,r|

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Safety

Safety Statements: 24/25
WGK Germany: 3
HS Code: 29335990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H341Suspected of causing genetic defects

H372Causes damage to organs through prolonged or repeated exposure

Precautionary statements

P202Do not handle until all safety precautions have been read and understood.

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P308+P313IF exposed or concerned: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: PHR1596
Product name: Pemetrexed for system suitability
Packaging: 500mg
Price: $105
Updated: 2024/03/01

Sigma-Aldrich

Product number: 1500659
Product name: Pemetrexed for system suitability
Purity: United States Pharmacopeia (USP) Reference Standard
Packaging: 100mg
Price: $436
Updated: 2024/03/01

Cayman Chemical

Product number: 14269
Product name: Pemetrexed (sodium salt hydrate)
Purity: ≥98%
Packaging: 5mg
Price: $61
Updated: 2024/03/01

Cayman Chemical

Product number: 14269
Product name: Pemetrexed (sodium salt hydrate)
Purity: ≥98%
Packaging: 10mg
Price: $112
Updated: 2024/03/01

Sigma-Aldrich

Product number: Y0001539
Product name: Pemetrexed disodium heptahydrate
Purity: European Pharmacopoeia (EP) Reference Standard
Packaging: y0001539
Price: $153
Updated: 2024/03/01

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Pemetrexed Disodium Heptahydrate Chemical Properties,Usage,Production

Description

Pemetrexed Disodium Heptahydrate(357166-29-1) is a multi-targeted antifolate with antitumor activity. Its formal name is N-[4-[2-(2-Amino-4,7-dihydro-4-oxo-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-L-glutamic acid disodium salt hydrate. It potently inhibits folate-dependent enzymes involved in both purine and pyrimidine synthesis including thymidylate synthase (Ki?= 109 nM), dihydrofolate reductase (Ki?= 7 nM), glycinamide ribonucleotide formyltransferase (Ki?= 9.3 μM), and aminoimidazole carboxamide ribonucleotide formyltransferase (Ki?= 3.6 μM). It is a clinically useful anticancer agent. Indirectly activates the metabolic kinase AMPK and consequently influences the mTORC1 pathway in human carcinomas. Activation of AMPK is associated with pemetrexed resistance. Induces G0/G1-phase cell cycle arrest in esophageal squamous cell carcinoma cells.

Uses

Pemetrexed Disodium Heptahydrate is an chemotherapy drug for the treatment of pleural mesothelioma and non-small cell lung cancer. Pemetrexed Disodium Heptahydrate exhibit inhibitory activities towards thymidylate synthase as well as other folate dependent enzymes.

Uses

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Definition

ChEBI: Pemetrexed disodium heptahydrate is an organic sodium salt that is the heptahydrate form of pemetrexed disodium. Inhibits thymidylate synthase (TS), 421 dihydrofolate reductase (DHFR), and glycinamide ribonucleotide formyltransferase (GARFT). It has a role as an antimetabolite, an antineoplastic agent, an EC 1.5.1.3 (dihydrofolate reductase) inhibitor, an EC 2.1.1.45 (thymidylate synthase) inhibitor and an EC 2.1.2.2 (phosphoribosylglycinamide formyltransferase) inhibitor. It is an organic sodium salt and a hydrate. It contains a pemetrexed disodium.

General Description

Pemetrexed Disodium Heptahydrate secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Pemetrexed is an anionic anticancer drug with a narrow therapeutic index. As a folate anti metabolite, it acts as an inhibitor of thymidylate synthase. It can act effectively against a broad-spectrum of solid tumors such as non-small-cell lung and breast cancers in clinical trials. It is also effective against both dihydrofolate reductase and glycinamide ribonucleotide formyl transferase.

Biochem/physiol Actions

Pemetrexed exhibits its activity against several tumors such as colorectal, breast, gastric, pancreatic, and cervical cancer. It acts as a substrate for multidrug resistance protein transporters.

in vitro

Pemetrexed (LY231514) disodium is a novel classical antifolate, the antitumor activity of which may result from simultaneous and multipie inhibition of several key folate-requiring enzymes via its polyglutamated metabolites. Pemetrexed (LY231514) is one of the best substrates that is known for the enzyme FPGS (Km=1.6 μM and Vmax/Km=621). It is likely that polyglutamation and the polyglutamated metabolites of LY231514 play profound roles in determining both the selectivity and the antitumor activity of this novel agent. Whereas LY23l5l4 only moderately inhibits TS (Ki=340 nM, recombinant mouse), the pentaglutamate of LY23l5l4 is 100-fold more potent (Ki=3.4 nM), making LY231514 one of the most potent folate-based TS inhibitors.

in vivo

The group of mice treated with PC61 plus Pemetrexed demonstrates statistically longer survival than other groups. In a survival analysis, significantly better survival is observed in the group of mice treated with PC61 plus Pemetrexed compare with those treated with PC61 alone, rat IgG plus Pemetrexed, or no treatment.

References

1) Shih?et al.?(1997),?LY231514, a pyrrolo[2,3-d]pyrimidine-based antifolate that inhibits multiple folate-requiring enzymes; Cancer Res.?57?1116 2) Hanauske?et al. (2001),?Pemetrexed disodium: a novel antifolate clinically active against multiple solid tumors; Oncologist?6?363 3) Rothbart?et al. (2010),?Pemetrexed indirectly activates the metabolic kinase AMPK in human carcinomas; Cancer Res.?70?10299 4) Qin?et al.?(2019),?AMPK activation induced in pemetrexed-treated cells is associated with development of drug resistance independently of target enzyme expression; Mol. Oncol.?13?1419 5) Li?et al.?(2019),?Pemetrexed exerts anticancer effects by inducing G0/G1-phase cell cycle arrest and activating the NOXA/Mcl-1 axis in human esophageal squamous cell carcinoma cells; Oncol. Lett.?17?1851

Pemetrexed Disodium Heptahydrate Preparation Products And Raw materials

Raw materials

Preparation Products

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Pemetrexed Disodium Heptahydrate Suppliers

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View Lastest Price from Pemetrexed Disodium Heptahydrate manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD

Product: Pemetrexed disodium hepthydrate 357166-29-1
Price: US $0.00-0.00/Kg/Drum
Min. Order: 1KG
Purity: 98%min
Supply Ability: 500kg
Release date: 2021-09-11

Hebei Yanxi Chemical Co., Ltd.

Product: Pemetrexed disodium heptahydrate 357166-29-1
Price: US $0.00/kg
Min. Order: 1kg
Purity: 0.99
Supply Ability: 20tons
Release date: 2023-10-12

SHANDONG BOYUAN PHARMACEUTICAL CO., LTD.

Product: Pemetrexed disodium hepthydrate 357166-29-1
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 99.7% HPLC
Supply Ability: 500000
Release date: 2023-09-05

357166-29-1, Pemetrexed Disodium HeptahydrateRelated Search:

4-(4-Hydroxybutyl)benzoic acid Methyl ester Pemetrexed disodium hemipentahydrate Methyl 4-bromobenzoate N-[4-[3-(2,6-DiaMino-1,4-dihydro-4-oxo-5-pyriMidinyl)-3-oxopropyl]benzoyl]-L-glutaMic Acid but-3-en-1-yl 4-methylbenzene-1-sulfonate PeMetrexed EP IMpurity A 4-[2-(2-Amino-4,7-dihydro-4-oxo-1H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoic acid methyl ester 4-[2-(2-Amino-4,7-dihydro-4-oxo-1H-pymol[2,3-d]pyrimodin-5-yl)ethyl]benzoic acid 2,4-Diamino-6-hydroxypyrimidine 3-Butyn-1-ol Methyl 4-(4-hydroxybut-1-ynyl)benzoate N-[4-[2-(2-Amino-4,7-dihydro-4-oxo-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-L-glutamic acid 1,5-diethyl ester N-[4-[2-(2-AMino-4,5,6,7-tetrahydro-4,6-dioxo-1H-pyrrolo[2,3-d]pyriMidin-5-yl)ethyl]benzoyl]-L-glutaMic Acid 3-Buten-1-ol Methyl 4-(4-oxobutyl)benzoate Pemetrexed Disodium Pemetrexed 4-[2’-(7’’-Deazaguanine)ethyl]benzoic Acid N-Hydroxysuccinimide Ester

N-[4-[2-(2-Amino-4,7-dihydro-4-oxo-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-L-glutamic acid disodium salt hydrate

Pemetrexed disodium hepthydrate

PeMetrexed disodiuM 7-hydrate

L-GlutaMic acid, N-[4-[2-(2-aMino-4,7-dihydro-4-oxo-1H-pyrrolo[2,3-d]pyriMidin-5-yl)ethyl]benzoyl]-, disodiuM salt, heptahydrate

Pemetrexed for system suitability

Pemetrexed (sodium salt hydrate)

N-[4-[2-(2-Amino-4,7-dihydro-4-oxo-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-L-glutamic acid disodium salt hepthydrate

7-dihydro-4-oxo-3H-pyrrolo[2

Pemetrexed disodium heptahydrate/Pemetrexed disodium

Sodium (2S)-2-({4-[2-(2-amino-4-oxo-4,7-dihydro-1H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl}amino)pentanedioate hydrate (2:1:7)

CS-248

Pemetrexed Disodium heptahydrate (EMDF)

Pemetrexed for system suitability CRS

Pemetrexed disodium heptahydrate CRS

Pemetrexed Disodium heptahydrate （CEP）

Sodium (S)-2-(4-(2-(2-amino-4-oxo-4,7-dihydro-1H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl)benzamido)pentanedioate heptahydrate

N-[4-[2-(2-Amino-4,7-dihydro-4-oxo-3H-pyrrolo[2,3-d]pyrimidi...

Pemetrexed disodium heptahydrateQ: What is Pemetrexed disodium heptahydrate Q: What is the CAS Number of Pemetrexed disodium heptahydrate Q: What is the storage condition of Pemetrexed disodium heptahydrate Q: What are the applications of Pemetrexed disodium heptahydrate

Pemetrexed Disodium (1500659)

Pemetrexed disodium 7 hydrate (CEP)

Pemetrexed disodium(7HO)

357166-29-1

C20H19N5Na2O67H2O

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