ChemicalBook > CAS DataBase List > 2-(Trifluoromethyl)nicotinic acid

2-(Trifluoromethyl)nicotinic acid

Product Name: 2-(Trifluoromethyl)nicotinic acid
CAS No.: 131747-43-8
Chemical Name: 2-(Trifluoromethyl)nicotinic acid
Synonyms: CAS:131747-43-8;2-(TRIFLUOROMETHYL)NICOTINIC ACID;2-(Trifluoromethyl)nicotinicacid,97%;2-(Trifluoromethyl)nicotinic acid ,98%;2-(TRIFLUOROMETHYL)PYRIDINE-3-CARBOXYLI&;2-(Trifluoromethyl)pyridine-3-carboxylicaci;2-(trifluoroMethyl)pyridin-3-carboxylic acid;2-(TRIFLUOROMETHYL)-3-PYRIDINECARBOXYLIC ACID;2-(Trifluoromethyl)pyridine-3-carboxylic acid;3-Pyridinecarboxylic acid, 2-(trifluoroMethyl)-
CBNumber: CB8251006
Molecular Formula: C7H4F3NO2
Formula Weight: 191.11
MOL File: 131747-43-8.mol

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2-(Trifluoromethyl)nicotinic acid Property

Melting point:: 184-188 °C
Boiling point:: 259.9±40.0 °C(Predicted)
Density: 1.484±0.06 g/cm3(Predicted)
storage temp.: Inert atmosphere,Room Temperature
solubility: Methanol (Slightly)
form: Solid
pka: 2.50±0.36(Predicted)
color: Off-White
InChI: InChI=1S/C7H4F3NO2/c8-7(9,10)5-4(6(12)13)2-1-3-11-5/h1-3H,(H,12,13)
InChIKey: BFROETNLEIAWNO-UHFFFAOYSA-N
SMILES: C1(C(F)(F)F)=NC=CC=C1C(O)=O
CAS DataBase Reference: 131747-43-8(CAS DataBase Reference)

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Safety

Hazard Codes: Xi,Xn
Risk Statements: 22-36/37/38
Safety Statements: 26-37
WGK Germany: 3
HazardClass: IRRITANT
HS Code: 29333990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word: Danger
Hazard statements: H301Toxic if swalloed
Precautionary statements: P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 681261
Product name: 2-(Trifluoromethyl)pyridine-3-carboxylic acid
Purity: 96%
Packaging: 500mg
Price: $160
Updated: 2023/06/20

TCI Chemical

Product number: T3132
Product name: 2-(Trifluoromethyl)nicotinic Acid
Purity: >97.0%(GC)(T)
Packaging: 1g
Price: $91
Updated: 2025/07/31

TCI Chemical

Product number: T3132
Product name: 2-(Trifluoromethyl)nicotinic Acid
Purity: >97.0%(GC)(T)
Packaging: 5g
Price: $363
Updated: 2025/07/31

TRC

Product number: T791325
Product name: 2-(Trifluoromethyl)nicotinic Acid
Packaging: 250mg
Price: $80
Updated: 2021/12/16

Frontier Specialty Chemicals

Product number: T11122
Product name: 2-(Trifluoromethyl)nicotinic Acid
Purity: 98%
Packaging: 25g
Price: $90
Updated: 2021/12/16

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2-(Trifluoromethyl)nicotinic acid Chemical Properties,Usage,Production

Chemical Properties

White to light brown powder or crystal

Uses

An intermediate for agrochemical fungicides.

Uses

A intermediate for agrochemical fungicides

Synthesis

208517-35-5

131747-43-8

In a 250 mL three-necked flask, sodium hydroxide solution (310 g, 7 wt%) and ethyl 2-trifluoromethylnicotinate (100 g) were added. The reaction mixture was heated to 100 °C and the reaction was stirred at this temperature for 1 hour. The progress of the reaction was monitored by gas chromatography (GC). When the conversion reached 99%, the heating was stopped and the reaction mixture was cooled to room temperature. The reaction mixture was neutralized with hydrochloric acid solution (61 g, 30 wt%) to pH neutral. Subsequently, the reaction mixture was filtered and the solid product was washed with water to give 2-trifluoromethylnicotinic acid. Yield: 97%; purity: 99.5%.

References

[1] Patent: WO2018/55640, 2018, A1. Location in patent: Page/Page column 5

2-(Trifluoromethyl)nicotinic acid Preparation Products And Raw materials

Raw materials

Hexamethylphosphoramide Copper Potassium hydroxide 2-Amino-3-picoline Sodium nitrite Hydrogen bromide Trifluoromethyl iodide Bromine Potassium permanganate Sodium hydroxide

Preparation Products

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View Lastest Price from 2-(Trifluoromethyl)nicotinic acid manufacturers

PNP Biotech Co. Ltd

Product: 2-(Trifluoromethyl)nicotinic acid 131747-43-8
Price: US $0.00/kg
Min. Order: 25kg
Purity: 98%
Supply Ability: Inquiry
Release date: 2023-07-11

Dideu Industries Group Limited

Product: 2-(Trifluoromethyl)nicotinic acid 131747-43-8
Price: US $1.10/g
Min. Order: 1g
Purity: 99.00%
Supply Ability: 100 Tons Min
Release date: 2021-10-22

Career Henan Chemical Co

Product: 2-(Trifluoromethyl)nicotinic acid 131747-43-8
Price: US $1.00/KG
Min. Order: 1KG
Purity: 95%
Supply Ability: 500kg
Release date: 2018-08-19

131747-43-8, 2-(Trifluoromethyl)nicotinic acidRelated Search:

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CAS:131747-43-8

131747-43-8

Building Blocks

Pyridines

Heterocyclic Building Blocks

Halogenated Heterocycles

Building Blocks

Pyridine

Aromatics Compounds

Aromatics

Heterocycles

Carboxylic Acids

Pyridines

Heterocycle