(1S-cis)-Milnacipran Hydrochloride
- Product Name
- (1S-cis)-Milnacipran Hydrochloride
- CAS No.
- 175131-60-9
- Chemical Name
- (1S-cis)-Milnacipran Hydrochloride
- Synonyms
- Levominaprine;L-Milnacipran HCl;Levomilnacipran HCl;Milnacipran (1S-cis);F 2695 hydrochloride;Sitafloxacin Impurity 70;Levomilnacipran HCl (F2695;L-Milnacipran Hydrochloride;LevoMilnacipran hydrochloride;(1S,2R)-Milnacipran hydrochloride
- CBNumber
- CB82510923
- Molecular Formula
- C15H23ClN2O
- Formula Weight
- 282.81
- MOL File
- 175131-60-9.mol
(1S-cis)-Milnacipran Hydrochloride Property
- storage temp.
- Store at -20°C
- solubility
- DMSO:57.0(Max Conc. mg/mL);201.55(Max Conc. mM)
- form
- A crystalline solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321Specific treatment (see … on this label).
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
N-Bromosuccinimide Price
- Product number
- 23951
- Product name
- Levomilnacipran (hydrochloride)
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $44
- Updated
- 2024/03/01
- Product number
- 23951
- Product name
- Levomilnacipran (hydrochloride)
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $172
- Updated
- 2024/03/01
- Product number
- 23951
- Product name
- Levomilnacipran (hydrochloride)
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $321
- Updated
- 2024/03/01
- Product number
- 23951
- Product name
- Levomilnacipran (hydrochloride)
- Purity
- ≥98%
- Packaging
- 25mg
- Price
- $692
- Updated
- 2024/03/01
- Product number
- M344595
- Product name
- (1S-cis)-MilnacipranHydrochloride
- Packaging
- 50mg
- Price
- $1230
- Updated
- 2021/12/16
(1S-cis)-Milnacipran Hydrochloride Chemical Properties,Usage,Production
Description
Levomilnacipran (Fetzima®) is a dual serotonin–norepinephrine reuptake inhibitor (SNRI) approved by the FDA in 2013 for the treatment of major depressive disorders (MDD). Levomilnacipran is the most active enantiomer of the racemate Milnacipran, which is currently used to treat pain associated with fibromyalgia. The drug was developed by Forest Laboratories and the Pierre Fabre group.
Uses
The (1S-cis)-enatiomer of Milnacipran (M344600). A selective norepinephrine and serotonin reuptake inhibitor approved for the management of fibromyalgia.
Uses
The S-enatiomer of Milnacipran (M344600).
Synthesis
Reaction of phenylacetonitrile (100) and commercially available (R)-epichlorohydrin (101) with NaNH2 led to chloride displacement and intramolecular cyclopropanation, yielding lactone 102 after a one-pot nitrile hydrolysis and acid-promoted lactonization (75% yield over 3 steps). Lactone ring-opening with Et2NH¨CAlCl3 complex provided amido-alcohol 103, which was converted to its phthalimido derivative 104 by sequential treatment with thionyl chloride and potassium phthalimide in 80% over three steps. Finally, levomilnacipran hydrochloride (XIII) was obtained in >95% optical purity after phthalimide cleavage, HCl salt formation, and crystallization from HCl/i-PrOH/i-PrAc. This sequence represents a highly efficient route to levomilnacipran, requiring no isolation of intermediates, resulting in >40% overall yield, and allowing use of the same solvent solution (toluene) for all steps.
(1S-cis)-Milnacipran Hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
(1S-cis)-Milnacipran Hydrochloride Suppliers
View Lastest Price from (1S-cis)-Milnacipran Hydrochloride manufacturers
- Product
- (1S-cis)-Milnacipran Hydrochloride 175131-60-9
- Price
- US $0.00/kg
- Min. Order
- 25kg
- Purity
- 98%-99%
- Supply Ability
- Inquiry
- Release date
- 2022-09-16
- Product
- (1S-cis)-Milnacipran Hydrochloride 175131-60-9
- Price
- US $2.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- ask
- Release date
- 2018-12-23