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(1S-cis)-Milnacipran Hydrochloride

Product Name
(1S-cis)-Milnacipran Hydrochloride
CAS No.
175131-60-9
Chemical Name
(1S-cis)-Milnacipran Hydrochloride
Synonyms
Levominaprine;L-Milnacipran HCl;Levomilnacipran HCl;Milnacipran (1S-cis);F 2695 hydrochloride;Sitafloxacin Impurity 70;Levomilnacipran HCl (F2695;L-Milnacipran Hydrochloride;LevoMilnacipran hydrochloride;(1S,2R)-Milnacipran hydrochloride
CBNumber
CB82510923
Molecular Formula
C15H23ClN2O
Formula Weight
282.81
MOL File
175131-60-9.mol
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(1S-cis)-Milnacipran Hydrochloride Property

storage temp. 
Store at -20°C
solubility 
DMSO:57.0(Max Conc. mg/mL);201.55(Max Conc. mM)
form 
A crystalline solid
color 
White to off-white
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

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N-Bromosuccinimide Price

Cayman Chemical
Product number
23951
Product name
Levomilnacipran (hydrochloride)
Purity
≥98%
Packaging
1mg
Price
$44
Updated
2024/03/01
Cayman Chemical
Product number
23951
Product name
Levomilnacipran (hydrochloride)
Purity
≥98%
Packaging
5mg
Price
$172
Updated
2024/03/01
Cayman Chemical
Product number
23951
Product name
Levomilnacipran (hydrochloride)
Purity
≥98%
Packaging
10mg
Price
$321
Updated
2024/03/01
Cayman Chemical
Product number
23951
Product name
Levomilnacipran (hydrochloride)
Purity
≥98%
Packaging
25mg
Price
$692
Updated
2024/03/01
TRC
Product number
M344595
Product name
(1S-cis)-MilnacipranHydrochloride
Packaging
50mg
Price
$1230
Updated
2021/12/16
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(1S-cis)-Milnacipran Hydrochloride Chemical Properties,Usage,Production

Description

Levomilnacipran (Fetzima®) is a dual serotonin–norepinephrine reuptake inhibitor (SNRI) approved by the FDA in 2013 for the treatment of major depressive disorders (MDD). Levomilnacipran is the most active enantiomer of the racemate Milnacipran, which is currently used to treat pain associated with fibromyalgia. The drug was developed by Forest Laboratories and the Pierre Fabre group.

Uses

The (1S-cis)-enatiomer of Milnacipran (M344600). A selective norepinephrine and serotonin reuptake inhibitor approved for the management of fibromyalgia.

Uses

The S-enatiomer of Milnacipran (M344600).

Synthesis

Reaction of phenylacetonitrile (100) and commercially available (R)-epichlorohydrin (101) with NaNH2 led to chloride displacement and intramolecular cyclopropanation, yielding lactone 102 after a one-pot nitrile hydrolysis and acid-promoted lactonization (75% yield over 3 steps). Lactone ring-opening with Et2NH¨CAlCl3 complex provided amido-alcohol 103, which was converted to its phthalimido derivative 104 by sequential treatment with thionyl chloride and potassium phthalimide in 80% over three steps. Finally, levomilnacipran hydrochloride (XIII) was obtained in >95% optical purity after phthalimide cleavage, HCl salt formation, and crystallization from HCl/i-PrOH/i-PrAc. This sequence represents a highly efficient route to levomilnacipran, requiring no isolation of intermediates, resulting in >40% overall yield, and allowing use of the same solvent solution (toluene) for all steps.

(1S-cis)-Milnacipran Hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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(1S-cis)-Milnacipran Hydrochloride Suppliers

Canada 1 China 107 India 13 Italy 1 Spain 1 United Kingdom 1 United States 11 Global 135
COSMA SPA
Tel
--
Fax
--
Email
cosma@gruppocosma.com
Country
Italy
ProdList
18
Advantage
58
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View Lastest Price from (1S-cis)-Milnacipran Hydrochloride manufacturers

PNP Biotech Co. Ltd
Product
(1S-cis)-Milnacipran Hydrochloride 175131-60-9
Price
US $0.00/kg
Min. Order
25kg
Purity
98%-99%
Supply Ability
Inquiry
Release date
2022-09-16
Career Henan Chemical Co
Product
(1S-cis)-Milnacipran Hydrochloride 175131-60-9
Price
US $2.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
ask
Release date
2018-12-23

175131-60-9, (1S-cis)-Milnacipran HydrochlorideRelated Search:

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  • (1S,2R)-2-(Aminomethyl)-N,N-diethyl-1-phenylcyclopropanecarboxamide hydrochloride , Milnacipran ((1S-cis) HCl
  • 175131-60-9
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