ChemicalBook > CAS DataBase List > CCT128930

CCT128930

Product Name: CCT128930
CAS No.: 885499-61-6
Chemical Name: CCT128930
Synonyms: CS-447;CCT128930;CCT128930, >=98%;CCT128930 (CCT 128930;4-(4-chlorobenzyl)-1-(7H-pyrrolo[2,3-d]pyriMidin-4-yl)piperidin-4-aMine;4-(4-Chlorobenzyl)-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidin-4-ylamine;4-[(4-Chlorophenyl)methyl]-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-4-piperidinamine;4-PiperidinaMine, 4-[(4-chlorophenyl)Methyl]-1-(7H-pyrrolo[2,3-d]pyriMidin-4-yl)-
CBNumber: CB82554024
Molecular Formula: C18H20ClN5
Formula Weight: 341.84
MOL File: 885499-61-6.mol

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CCT128930 Property

Density: 1.39
storage temp.: Store at -20°C
solubility: DMSO : 36.67 mg/mL (107.27 mM; Need ultrasonic)
form: Powder
pka: 13.93±0.50(Predicted)
color: Off-white to yellow
InChI: InChI=1S/C18H20ClN5/c19-14-3-1-13(2-4-14)11-18(20)6-9-24(10-7-18)17-15-5-8-21-16(15)22-12-23-17/h1-5,8,12H,6-7,9-11,20H2,(H,21,22,23)
InChIKey: RZIDZIGAXXNODG-UHFFFAOYSA-N
SMILES: N1(C2N=CN=C3NC=CC3=2)CCC(CC2=CC=C(Cl)C=C2)(N)CC1

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Safety

HS Code: 2933399990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 18194
Product name: CCT128930
Purity: ≥95%
Packaging: 1mg
Price: $44
Updated: 2024/03/01

Cayman Chemical

Product number: 18194
Product name: CCT128930
Purity: ≥95%
Packaging: 5mg
Price: $172
Updated: 2024/03/01

Cayman Chemical

Product number: 18194
Product name: CCT128930
Purity: ≥95%
Packaging: 10mg
Price: $321
Updated: 2024/03/01

Cayman Chemical

Product number: 18194
Product name: CCT128930
Purity: ≥95%
Packaging: 50mg
Price: $1027
Updated: 2024/03/01

TRC

Product number: C227955
Product name: CCT128930
Packaging: 5mg
Price: $270
Updated: 2021/12/16

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CCT128930 Chemical Properties,Usage,Production

Uses

CCT128930 is a potent, ATP-competitive and selective inhibitor of Akt2 with IC50 of 6 nM.

Uses

CCT128930 is a potent, ATP-competitive and selective inhibitor of Akt2.

in vivo

CCT128930 (25 or 40 mg/kg; i.p. daily or twice daily for 5 days) shows antitumor activities in U87MG and BT474 human breast cancer xenografts^[1].
Summary of the pharmacokinetic parameters of CCT128930 (25 mg/kg) in CrTacNCr-Fox1nu mice^[1]

Tissue	Route	T_1/2 (h)	T_max (h)	C_max (μM)	V_ss (L)	Cl (L/h)	AUC_0-∞ (μMh)	Bioavailability (%)
Plasma	i.v.	0.95	0.083	6.36	0.25	0.325	4.62	100
Plasma	i.p.	2.33	0.5	1.28	N/A	0.372	1.33	28.8
Tumor	i.p.	3.89	1	8.02	N/A	0.06^*	25.8	N/A
Plasma	p.o.	0.57	0.5	0.432	N/A	0.317	0.392	8.5

^*Apparent clearance.

Animal Model:	6-8 weeks old female CrTacNCr-Fox1nu mice^[1]
Dosage:	25 mg/kg (U87MG human glioblastoma xenografts) or 40 mg/kg (BT474 human breast cancer xenografts)
Administration:	i.p. daily for 5 days (U87MG human glioblastoma xenografts); i.p. twice daily for 5 days (BT474 human breast cancer xenografts)
Result:	Giving a treated:control (T/C) ratio on day 12 of 48%. There was no weight loss associated with this regime in U87MG human glioblastoma xenografts. Had a profound antitumor effect with complete growth arrest and a T/C ratio of 29% on day 22. This regimen was associated with minimal weight loss, with a nadir of only 94.8% of the initial body weight on day 15 of treatment in BT474 human breast cancer xenografts.

target

Akt2

IC 50

Akt2: 6 nM (IC₅₀); p70S6K: 120 nM (IC₅₀); PKA: 168 nM (IC₅₀); Autophagy; Apoptosis

CCT128930 Preparation Products And Raw materials

Raw materials

Preparation Products

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CCT128930 Suppliers

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885499-61-6, CCT128930Related Search:

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4-(4-chlorobenzyl)-1-(7H-pyrrolo[2,3-d]pyriMidin-4-yl)piperidin-4-aMine

CCT128930 (CCT 128930

CS-447

4-[(4-Chlorophenyl)methyl]-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-4-piperidinamine

4-PiperidinaMine, 4-[(4-chlorophenyl)Methyl]-1-(7H-pyrrolo[2,3-d]pyriMidin-4-yl)-

CCT128930, >=98%

CCT128930

4-(4-Chlorobenzyl)-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidin-4-ylamine

885499-61-6

C18H20ClN5

Akt

mTOR

PI3K

Inhibitors