ChemicalBook > CAS DataBase List > VU 0364770

VU 0364770

Product Name: VU 0364770
CAS No.: 61350-00-3
Chemical Name: VU 0364770
Synonyms: SKL856;VU 0364770;VU 0364770 100MG;VU 0364770 USP/EP/BP;VU0364770;VU-0364770;VU0364770, 10 mM in DMSO;N-(3-Chlorophenyl)picolinamide;N-(3-chlorophenyl)pyridine-2-carboxamide;2-PyridinecarboxaMide, N-(3-chlorophenyl)-
CBNumber: CB82596686
Molecular Formula: C12H9ClN2O
Formula Weight: 232.67
MOL File: 61350-00-3.mol

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VU 0364770 Property

Melting point:: 81-83 °C
Boiling point:: 293.6±20.0 °C(Predicted)
Density: 1.341±0.06 g/cm3(Predicted)
storage temp.: Inert atmosphere,Store in freezer, under -20°C
solubility: DMF: 30 mg/ml; DMF:PBS (pH 7.2) (1:1): 0.5 mg/ml; DMSO: 25 mg/ml; Ethanol: 5 mg/ml
form: Powder
pka: 11.24±0.70(Predicted)
color: Light yellow to yellow

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 22927
Product name: VU0364770
Packaging: 5mg
Price: $81
Updated: 2024/03/01

Cayman Chemical

Product number: 22927
Product name: VU0364770
Packaging: 10mg
Price: $129
Updated: 2024/03/01

Cayman Chemical

Product number: 22927
Product name: VU0364770
Packaging: 25mg
Price: $298
Updated: 2024/03/01

Cayman Chemical

Product number: 22927
Product name: VU0364770
Packaging: 50mg
Price: $435
Updated: 2024/03/01

Tocris

Product number: 4469
Product name: VU0364770
Purity: ≥99%(HPLC)
Packaging: 10
Price: $173
Updated: 2021/12/16

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VU 0364770 Chemical Properties,Usage,Production

Uses

N-(3-Chlorophenyl)-2-pyridinecarboxamide shows positive allosteric modulation at the mGlu4 receptors in combination with other antagonists resulting in treatment for the neurodegenerative Parkinson’s disease (1).

in vivo

VU0364770 exhibits suitable pharmacokinetic properties for systemic dosing in animal models. After intravenous administration, VU0364770 is rapidly clears from the systemic circulation (165 ml/min/kg) and exhibits a volume of distribution of 2.92 L/kg. VU0364770 is a highly protein-bound ligand displaying free fractions of 2.7 and 1.8% in human and rat plasma, respectively. VU0364770 also shows an improved pharmacokinetic profile relative to previously reported mGlu₄ PAMs with enhanced central penetration and a total brain-to-plasma ratio of more than 1 after systemic administration of a 10 mg/kg dose. VU0364770 produces a dose-dependent reversal of haloperidol-induced catalepsy. VU0364770 dose-dependently reverses haloperidol (0.75 mg/kg)-induced catalepsy in rats, significant at doses of 10 to 56.6 mg/kg, after subcutaneous dosing (F_6,69=8.04; p<0.001)^[1].

IC 50

Rat mGlu₄: 290 nM (EC₅₀); Human mGlu₄: 1.1 μM (EC₅₀); mGlu₆: 6.8 μM (EC₅₀); mGlu₅: 17.9 μM (EC₅₀)

VU 0364770 Preparation Products And Raw materials

Raw materials

Preparation Products

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VU 0364770 Suppliers

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61350-00-3, VU 0364770Related Search:

N-[3-Oxo-3-[4-(4-pyridinyl)-1-piperazinyl]propyl]-2,1,3-benzothiadiazole-4-sulfonamide VU0155041 VU0134992(hydrochloride) VU6005649 VU 591 hydrochloride VU0810464 VU0483605 N-(4-Chloro-3-methoxyphenyl)-2-pyridinecarboxamide 1-(4-Methoxybenzyl)-5-trifluoromethoxyisatin VU 6008667 (1R,2R)-N-([S]-1-{4-[5-broMo-2-oxo-2,3-dihydro-1H-benzo(d)iMidazol-1-yl]piperidin-1-yl}propan-2-yl)-2-phenylcyclopropanecarboxaMide 5-Amino-3,4-dimethyl-thieno[2,3-c]pyridazine-6-carboxylic acid 4-trifluoromethanesulfonyl-benzylamide 3-methylsulfanyl-7,8-dihydro-6H-cyclopenta[4,5]thieno[1,2-c]pyrimidin-1-amine VU 0360172 VU 0365114 VU 0357121 VU 0360223 VU 0364439

VU 0364770

2-PyridinecarboxaMide, N-(3-chlorophenyl)-

N-(3-Chlorophenyl)picolinamide

N-(3-chlorophenyl)pyridine-2-carboxamide

VU 0364770 100MG

VU0364770;VU-0364770

VU 0364770 USP/EP/BP

SKL856

VU0364770, 10 mM in DMSO

61350-00-3

Aromatics, Heterocycles

Inhibitors