TYRPHOSTIN A51
- Product Name
- TYRPHOSTIN A51
- CAS No.
- 122520-90-5
- Chemical Name
- TYRPHOSTIN A51
- Synonyms
- AG 183;TYRPHOSTIN 51;TYRPHOSTIN A51;TYRPHOSTIN AG 183;TYRPHOSTIN A51 99+%;Tyrphostin 51(AG-183);TYRPHOSTIN A51 USP/EP/BP;2-AMINO-1,1,3-TRICYANO-4-[3',4',5'-TRIHYDROXYPHENYL]BUTADIENE;2-AMINO-4-(3',4',5'-TRIHYDROXYPHENYL)-1,1,3-TRICYANOBUTA-1,3-DIENE;3-AMINO-2,4-DICYANO-5-(3',4',5'-TRIHYDROXYPHENYL)PENTA-2,4-DIENONITRILE
- CBNumber
- CB8260628
- Molecular Formula
- C13H8N4O3
- Formula Weight
- 268.23
- MOL File
- 122520-90-5.mol
TYRPHOSTIN A51 Property
- Melting point:
- 275 °C
- Boiling point:
- 788.2±60.0 °C(Predicted)
- Density
- 1.591±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- solubility
- ≤20mg/ml in DMSO;20mg/ml in dimethyl formamide
- form
- Orange solid.
- pka
- 8.46±0.15(Predicted)
Safety
- WGK Germany
- 3
- HazardClass
- 6.1
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Hazard statements
-
H302Harmful if swallowed
H312Harmful in contact with skin
H315Causes skin irritation
H319Causes serious eye irritation
H332Harmful if inhaled
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- J67135
- Product name
- Tyrphostin AG-183
- Purity
- 98%
- Packaging
- 5mg
- Price
- $56.8
- Updated
- 2021/12/16
- Product number
- J67135
- Product name
- Tyrphostin AG-183
- Purity
- 98%
- Packaging
- 10mg
- Price
- $101
- Updated
- 2021/12/16
- Product number
- 10010315
- Product name
- AG-183
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $40
- Updated
- 2024/03/01
- Product number
- 10010315
- Product name
- AG-183
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $76
- Updated
- 2024/03/01
- Product number
- J67135
- Product name
- Tyrphostin AG-183
- Purity
- 98%
- Packaging
- 25mg
- Price
- $236
- Updated
- 2021/12/16
TYRPHOSTIN A51 Chemical Properties,Usage,Production
Description
Protein tyrosine kinase (PTK) inhibitors are potential antiproliferative agents for diseases caused by the hyperactivity of PTKs. Tyrphostins are a class of antiproliferative compounds which act as PTK blockers. PTK inhibitors which preferentially inhibit the epidermal growth factor (EGF) receptor kinase block EGF-
Uses
Tyrphostin 51 is a potent inhibitor of EGFRK activity showing mixed competitive inhibition with ATP and substrate1-3..
Definition
ChEBI: 2-amino-4-(3,4,5-trihydroxyphenyl)buta-1,3-diene-1,1,3-tricarbonitrile is a benzenetriol.
References
[1] gazit a, yaish p, gilon c, et al. tyrphostins i: synthesis and biological activity of protein tyrosine kinase inhibitors[j]. journal of medicinal chemistry, 1989, 32(10): 2344-2352.
[2] hubbard s r, till j h. protein tyrosine kinase structure and function[j]. annual review of biochemistry, 2000, 69(1): 373-398.
TYRPHOSTIN A51 Preparation Products And Raw materials
Raw materials
Preparation Products
TYRPHOSTIN A51 Suppliers
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- United Kingdom
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