4SC-202
- Product Name
- 4SC-202
- CAS No.
- 1186222-89-8
- Chemical Name
- 4SC-202
- Synonyms
- CS-1272;4SC-202;4SC-202.TsOH;4SC-202 tosylate;Domatinostat tosylate;4SC-202;4SC202;4SC 202;Domatinostat tosylate,Domatinostat,Apoptosis,inhibit,Histone deacetylases,Inhibitor,HDAC;(E)-N-(2-aminophenyl)-3-(1-((4-(1-methyl-1H-pyrazol-4-yl)phenyl)sulfonyl)-1H-pyrrol-3-yl)acrylamide 4-methylbenzenesulfonate;4SC-202 2-Propenamide, N-(2-aminophenyl)-3-[1-[[4-(1-methyl-1H-pyrazol-4-yl)phenyl]sulfonyl]-1H-pyrrol-3-yl]-, (2E)-, 4-methylbenzenesul
- CBNumber
- CB82624903
- Molecular Formula
- C30H29N5O6S2
- Formula Weight
- 619.71116
- MOL File
- 1186222-89-8.mol
4SC-202 Property
- storage temp.
- Store at -20°C
- solubility
- insoluble in H2O; ≥2.4 mg/mL in EtOH with gentle warming and ultrasonic; ≥62 mg/mL in DMSO
- form
- Powder
- color
- Light yellow to brown
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H301Toxic if swalloed
H311Toxic in contact with skin
H315Causes skin irritation
H317May cause an allergic skin reaction
H331Toxic if inhaled
H341Suspected of causing genetic defects
H411Toxic to aquatic life with long lasting effects
- Precautionary statements
-
P201Obtain special instructions before use.
P202Do not handle until all safety precautions have been read and understood.
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P271Use only outdoors or in a well-ventilated area.
P272Contaminated work clothing should not be allowed out of the workplace.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P281Use personal protective equipment as required.
P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P308+P313IF exposed or concerned: Get medical advice/attention.
P311Call a POISON CENTER or doctor/physician.
P312Call a POISON CENTER or doctor/physician if you feel unwell.
P321Specific treatment (see … on this label).
P322Specific measures (see …on this label).
P330Rinse mouth.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P333+P313IF SKIN irritation or rash occurs: Get medical advice/attention.
P361Remove/Take off immediately all contaminated clothing.
P362Take off contaminated clothing and wash before reuse.
P363Wash contaminated clothing before reuse.
P403+P233Store in a well-ventilated place. Keep container tightly closed.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 26175
- Product name
- 4SC-202
- Packaging
- 25mg
- Price
- $558
- Updated
- 2024/03/01
- Product number
- 26175
- Product name
- 4SC-202
- Packaging
- 50mg
- Price
- $979
- Updated
- 2024/03/01
- Product number
- 26175
- Product name
- 4SC-202
- Packaging
- 5mg
- Price
- $141
- Updated
- 2024/03/01
- Product number
- 26175
- Product name
- 4SC-202
- Packaging
- 10mg
- Price
- $253
- Updated
- 2024/03/01
- Product number
- B4106
- Product name
- 4SC-202
- Packaging
- 5mg
- Price
- $100
- Updated
- 2021/12/16
4SC-202 Chemical Properties,Usage,Production
Description
4SC-202 is an inhibitor of the class I histone deacetylases (HDACs) HDAC1-3 and the histone demethylase KDM1A. It reduces cell viability in a panel of colorectal cancer (CRC) cell lines when used at concentrations ranging from 1 to 10 μM and in patient-derived CRC cell lines when used at a concentration of 5 μM. 4SC-202 (5 μM) induces cell cycle arrest at the G2/M phase in HT-29 cells and primary human CRC cells and increases apoptosis in HT-29 cells in a concentration-dependent manner, an effect that is enhanced by the Akt inhibitors perifosine and MK-2206 . 4SC-202 (100 mg/kg, p.o., every other day) reduces tumor growth in an HT-29 mouse xenograft model when administered alone and to an enhanced degree when co-administered with oxaliplatin (Item No. 13106).
in vivo
studies, 4sc-202 has shown a good tolerability and dose-dependent effect on anti-tumour activity compared with other inhibitors in the a549nsclc xenograft model and the rko27 colon carcinoma model [1].
References
[1] henning s w, doblhofer r, kohlhof h, et al. 178 preclinical characterization of 4sc-202, a novel isotype specific hdac inhibitor[j]. european journal of cancer supplements, 2010, 8(7): 61.
4SC-202 Preparation Products And Raw materials
Raw materials
Preparation Products
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