ChemicalBook > CAS DataBase List > BenzenesulfonaMide, 5-(phenylsulfonyl)-N-4-piperidinyl-2-(trifluoroMethyl)-

BenzenesulfonaMide, 5-(phenylsulfonyl)-N-4-piperidinyl-2-(trifluoroMethyl)-

Product Name
BenzenesulfonaMide, 5-(phenylsulfonyl)-N-4-piperidinyl-2-(trifluoroMethyl)-
CAS No.
915759-45-4
Chemical Name
BenzenesulfonaMide, 5-(phenylsulfonyl)-N-4-piperidinyl-2-(trifluoroMethyl)-
Synonyms
316606;CS-2786;WAY-316606;WAY 316606;way-316606 /way 316606;WAY 316606, 10 mM in DMSO;WAY 316606 HCl(free base);WAY-316606;WAY 316606;WAY316606;2-[(2S)-2-Oxiranylmethyl]-1H-isoindole-1;5-(benzenesulfonyl)-N-piperidin-4-yl-2-(trifluoromethyl)benzenesulfonamide
CBNumber
CB82627535
Molecular Formula
C18H19F3N2O4S2
Formula Weight
448.48
MOL File
915759-45-4.mol
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BenzenesulfonaMide, 5-(phenylsulfonyl)-N-4-piperidinyl-2-(trifluoroMethyl)- Property

Boiling point:
601.1±65.0 °C(Predicted)
Density 
1.50±0.1 g/cm3(Predicted)
solubility 
DMF: 3 mg/ml; DMSO: 3 mg/ml; DMSO:PBS (pH 7.2) (1:10): 0.1 mg/ml
pka
8.76±0.20(Predicted)
form 
Powder
color 
White to off-white
InChI
InChI=1S/C18H19F3N2O4S2/c19-18(20,21)16-7-6-15(28(24,25)14-4-2-1-3-5-14)12-17(16)29(26,27)23-13-8-10-22-11-9-13/h1-7,12-13,22-23H,8-11H2
InChIKey
ITBGJNVZJBVPLJ-UHFFFAOYSA-N
SMILES
C1(S(NC2CCNCC2)(=O)=O)=CC(S(C2=CC=CC=C2)(=O)=O)=CC=C1C(F)(F)F
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical
Product number
26324
Product name
WAY-316606
Packaging
1mg
Price
$37
Updated
2024/03/01
Cayman Chemical
Product number
26324
Product name
WAY-316606
Packaging
5mg
Price
$161
Updated
2024/03/01
Cayman Chemical
Product number
26324
Product name
WAY-316606
Packaging
10mg
Price
$266
Updated
2024/03/01
ChemScene
Product number
CS-0996
Product name
WAY316606
Purity
99.61%
Packaging
5mg
Price
$110
Updated
2021/12/16
ChemScene
Product number
CS-0996
Product name
WAY316606
Purity
99.61%
Packaging
10mg
Price
$220
Updated
2021/12/16
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BenzenesulfonaMide, 5-(phenylsulfonyl)-N-4-piperidinyl-2-(trifluoroMethyl)- Chemical Properties,Usage,Production

Description

WAY-316606 is an inhibitor of secreted frizzled-related protein 1 (sFRP-1; IC50 = 0.5 μM). It increases Wnt signaling in U2OS osteosarcoma cells (EC50 = 0.65 μM). WAY-316606 increases total bone area in a murine calvarial organ culture assay when used at concentrations greater than 0.1 nM.

Uses

WAY 316606 is an inhibitor of the secreted protein sFRP-1, an endogenous antagonist of the secreted glycoprotein Wnt. The affinity of WAY-316606 for sFRP-1 is determined using the FP binding assay with IC50 of 0.5 μM[1].

Definition

ChEBI: WAY-316606 is a sulfonamide resulting from the formal condensation of the sulfonic acid group of 5-(phenylsulfonyl)-2-(trifluoromethyl)benzenesulfonic acid with the primary amino group of piperidin-4-amine. An inhibitor of secreted Frizzled-Related Protein-1 (sFRP-1). It has a role as a secreted frizzled-related protein 1 inhibitor. It is a sulfone, a sulfonamide, a member of (trifluoromethyl)benzenes, a member of piperidines and a secondary amino compound.

in vivo

WAY-316606 increases bone formation when tested in a neonatal murine calvarial assay. WAY-316606 increases total bone area up to 60% in a dose-dependent manner with an EC50 of about 1 nM. WAY-316606 exhibits moderate to low inhibition of cytochrome p450 isozymes (3A4, 2D6, 2C9) and good stability in rat and human liver microsomes (t1/2>60 min in each species). In female Sprague-Dawley rats, WAY-316606 exhibits high plasma clearance (77 mL/min/kg, greater than hepatic blood flow) following a single intravenous bolus dose (2 mg/kg), which results in a rapid decline of drug exposure in the plasma despite the route of administration[2].

References

[1] Moore, WJ, et al. Modulation of Wnt Signaling Through Inhibition of Secreted Frizzled-Related Protein I (sFRP-1) with N-Substituted Piperidinyl Diphenylsulfonyl Sulfonamides. Journal of Medicinal Chemistry (2009), 52(1), 105-116. DOI:10.1021/jm801144h
[2] Bodine PV, et al. A small molecule inhibitor of the Wnt antagonist secreted frizzled-related protein-1 stimulates bone formation. Bone. 2009 Jun;44(6):1063-8. DOI:10.1016/j.bone.2009.02.013

BenzenesulfonaMide, 5-(phenylsulfonyl)-N-4-piperidinyl-2-(trifluoroMethyl)- Preparation Products And Raw materials

Raw materials

Preparation Products

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BenzenesulfonaMide, 5-(phenylsulfonyl)-N-4-piperidinyl-2-(trifluoroMethyl)- Suppliers

China 110 India 1 The Netherlands 1 United Kingdom 1 United States 12 Global 125
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View Lastest Price from BenzenesulfonaMide, 5-(phenylsulfonyl)-N-4-piperidinyl-2-(trifluoroMethyl)- manufacturers

Xi an Biohorlden Industry Trade Co Ltd
Product
WAY316606 915759-45-4
Price
US $0.00-0.00/g
Min. Order
10g
Purity
99%
Supply Ability
10 kg
Release date
2025-04-22
Shaanxi TNJONE Pharmaceutical Co., Ltd
Product
Way316606 ;Way-316606 915759-45-4
Price
US $0.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
10000kg
Release date
2024-05-09
Hebei Yanxi Chemical Co., Ltd.
Product
WAY316606 915759-45-4
Price
US $40.00/kg
Min. Order
1kg
Purity
0.99
Supply Ability
10 tons
Release date
2023-10-07

915759-45-4, BenzenesulfonaMide, 5-(phenylsulfonyl)-N-4-piperidinyl-2-(trifluoroMethyl)-Related Search:

1-[4-(6-nitro-3-pyridinyl)-1-piperazinyl]ethanone 1-Methyl-4-piperidone WAY 100635 1,3-Benzenediol, 4-[1-(2-propenyl)-7-(trifluoromethyl)-1H-indazol-3-yl]- CYCLOHEXANECARBOXAMIDE, N-[2-[4-(2-METHOXYPHENYL)-1-PIPERAZINYL]ETHYL]-N-2-PYRIDINYL-, HYDROCHLORIDE (1:3) WAY 208466 dihydrochloride WAY-204688 WAY-600 MAY-262611 WAY-151932 7-Bromo-2-(4-hydroxyphenyl)-1,3-benzoxazol-5-ol

  • BenzenesulfonaMide, 5-(phenylsulfonyl)-N-4-piperidinyl-2-(trifluoroMethyl)-
  • WAY 316606
  • WAY-316606
  • 5-(Phenylsulfonyl)-N-(piperidin-4-yl)-2-(trifluoromethyl)benzenesulfonamide
  • WAY-316606;WAY 316606;WAY316606
  • 5-(benzenesulfonyl)-N-piperidin-4-yl-2-(trifluoromethyl)benzenesulfonamide
  • CS-2786
  • way-316606 /way 316606
  • 2-[(2S)-2-Oxiranylmethyl]-1H-isoindole-1
  • WAY 316606 HCl(free base)
  • WAY 316606, 10 mM in DMSO
  • 316606
  • 915759-45-4
  • 915759-54-4
  • C18H19F3N2O4S2