PF 04447943
- Product Name
- PF 04447943
- CAS No.
- 1082744-20-4
- Chemical Name
- PF 04447943
- Synonyms
- EOS-62041;PF 4447943;PF-04447943;PF 04447943;PF 4447943;PF-4447943;PF04447943; PF 04447943;PF 04447943 - PF 4447943;PF-04447943 >=98% (HPLC);PDE9 Inhibitor, PF-04447943 - CAS 1082744-20-4 - Calbiochem;(tetrahydro-2H-pyran-4-yl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one
- CBNumber
- CB82645148
- Molecular Formula
- C20H25N7O2
- Formula Weight
- 395.46
- MOL File
- 1082744-20-4.mol
PF 04447943 Property
- Boiling point:
- 599.8±60.0 °C(Predicted)
- Density
- 1.52±0.1 g/cm3(Predicted)
- storage temp.
- -20C
- solubility
- Soluble in DMSO
- form
- Off-white solid
- pka
- 7.22±0.60(Predicted)
- color
- Light yellow to yellow
N-Bromosuccinimide Price
- Product number
- 5.38337
- Product name
- PDE9 Inhibitor, PF-04447943 - CAS 1082744-20-4 - Calbiochem
- Packaging
- 10mg
- Price
- $246
- Updated
- 2024/03/01
- Product number
- 24299
- Product name
- PF-04447943
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $36
- Updated
- 2024/03/01
- Product number
- 24299
- Product name
- PF-04447943
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $95
- Updated
- 2024/03/01
- Product number
- 24299
- Product name
- PF-04447943
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $172
- Updated
- 2024/03/01
- Product number
- 24299
- Product name
- PF-04447943
- Purity
- ≥98%
- Packaging
- 25mg
- Price
- $384
- Updated
- 2024/03/01
PF 04447943 Chemical Properties,Usage,Production
Biological Activity
pf-04447943 is a potent and selective inhibitor of pde9 [1].phosphodiesterase 9 (pde9) selectively degrades cgmp and limits the cgmp-mediated signal transduction which occurs following glutamate binding to nmda receptors. pde9 in cortex and hippocampus of rodents and humans play an important role in memory and learning [1].pf-04447943 have high affinity with ki of 2.8, 4.5 and 18 nm for human, rhesus and rat recombinant pde9 respectively and high selectivity for pde9 versus pdes1- 8 and 10 -11. in cultured hippocampal neurons, pf-04447943 (30-100 nm) significantly increased neurite outgrowth and synapse formation. also, pf-04447943 (100 nm) significantly facilitated hippocampal slice ltp evoked by a weak tetanic stimulus [1].in mice model, pf-04447943 (1 mg/kg) significantly reduced the time spent interacting with the female mouse during the second encounter 24 h later compared to the first encounter, which suggested that pf-04447943 enhanced recognition memory. while, pf-04447943 (3 or 10 mg/kg) didn’t change the interaction times for each encounter. these results suggested that pf-04447943 enhanced memory with an inverted u-shaped dose-response efficacy curve [1].
References
[1]hutson ph, finger en, magliaro bc, et al. the selective phosphodiesterase 9 (pde9) inhibitor pf-04447943(6-[(3s,4s)-4-methyl-1-(pyrimidin-2-ylmethyl)pyrrolidin-3-yl]-1-(tetrahydro-2h-pyran-4-yl)-1,5-dihydro-4h-pyrazolo[3,4-d]pyrimidin-4-one) enhances synaptic plasticity and cognitive function in rodents. neuropharmacology, 2011, 61(4): 665-676.
PF 04447943 Preparation Products And Raw materials
Raw materials
Preparation Products
PF 04447943 Suppliers
- Tel
- --
- Fax
- --
- info@axonmedchem.com
- Country
- The Netherlands
- ProdList
- 477
- Advantage
- 30