ChemicalBook > CAS DataBase List > Benzo[b]thiophene, 2-[(5-broMo-2-fluorophenyl)Methyl]-

Benzo[b]thiophene, 2-[(5-broMo-2-fluorophenyl)Methyl]-

Product Name: Benzo[b]thiophene, 2-[(5-broMo-2-fluorophenyl)Methyl]-
CAS No.: 1034305-17-3
Chemical Name: Benzo[b]thiophene, 2-[(5-broMo-2-fluorophenyl)Methyl]-
Synonyms: 2-(5-BroMo-2-fluorobenzyl)benzothiophene;2-(5-BroMo-2-fluorobenzyl)benzo[b]thiophene;Ipragliflozin-004;Azilsartan Impurity 64;Ipragliflozin Impurity B;Ipragliflozin Impurity 9;Ipragliflozin intermediate 1;Ipragliflozin impurity B (B4);2-[(5-broMo-2-fluorophenyl)Methyl]-;2-(5-Eromo-2-fluorobenzyl)benzobthiophene
CBNumber: CB82652155
Molecular Formula: C15H10BrFS
Formula Weight: 321.21
MOL File: 1034305-17-3.mol

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Benzo[b]thiophene, 2-[(5-broMo-2-fluorophenyl)Methyl]- Property

Boiling point:: 408.9±35.0 °C(Predicted)
Density: 1.509±0.06 g/cm3(Predicted)
storage temp.: 2-8°C(protect from light)
Appearance: White to off-white Solid
InChI: InChI=1S/C15H10BrFS/c16-12-5-6-14(17)11(7-12)9-13-8-10-3-1-2-4-15(10)18-13/h1-8H,9H2
InChIKey: IKGTVOQAJKYBGO-UHFFFAOYSA-N
SMILES: C12=CC=CC=C1C=C(CC1=CC(Br)=CC=C1F)S2

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC

Product number: B961545
Product name: 2-(5-Bromo-2-fluorobenzyl)benzo[b]thiophene
Packaging: 100mg
Price: $175
Updated: 2021/12/16

TRC

Product number: B961545
Product name: 2-(5-Bromo-2-fluorobenzyl)benzo[b]thiophene
Packaging: 50mg
Price: $110
Updated: 2021/12/16

AK Scientific

Product number: 3115AH
Product name: 2-(5-Bromo-2-fluorobenzyl)benzo[B]thiophene
Packaging: 1g
Price: $123
Updated: 2021/12/16

Ambeed

Product number: A111765
Product name: 2-(5-Bromo-2-fluorobenzyl)benzo[b]thiophene
Purity: 97%
Packaging: 5g
Price: $153
Updated: 2021/12/16

Chemenu

Product number: CM130309
Product name: 2-(5-Bromo-2-fluorobenzyl)benzo[b]thiophene
Purity: 95%+
Packaging: 5g
Price: $205
Updated: 2021/12/16

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Benzo[b]thiophene, 2-[(5-broMo-2-fluorophenyl)Methyl]- Chemical Properties,Usage,Production

Synthesis

1034305-11-7

1034305-17-3

General procedure for the synthesis of 2-(5-bromo-2-fluorobenzyl)benzo[b]thiophene from benzo[b]thiophen-2-yl(5-bromo-2-fluorophenyl)methanol: 35.4 g (105 mmol) of benzo[b]thiophene-2-yl(5-bromo-2-fluorophenyl)methanol, a compound of Formula 3, was dissolved in 800 mL of dichloromethane, and the solution was cooled to -20 °C. To this solution, 36.5 mL (230 mmol) of triethylsilane and 15.2 mL (120 mmol) of boron trifluoride ethyl ether compound were slowly added under stirring. The reaction mixture was kept stirred at -20°C for 30 minutes. Upon completion of the reaction, saturated aqueous sodium bicarbonate solution was added to the mixture to neutralize the reaction. The organic phase was separated, dried with anhydrous magnesium sulfate, filtered and concentrated under reduced pressure to remove the solvent. The resulting crude product was purified by column chromatography (eluent: ethyl acetate/hexane mixed solvent) to afford the target product 2-(5-bromo-2-fluorobenzyl)benzo[b]thiophene (Compound 4) 30.4 g, with 99.5% purity and 90.1% yield.

References

[1] Patent: CN108276396, 2018, A. Location in patent: Paragraph 0041; 0048; 0049; 0064; 0079
[2] Bioorganic and Medicinal Chemistry, 2012, vol. 20, # 10, p. 3263 - 3279
[3] Patent: CN108623558, 2018, A. Location in patent: Paragraph 0042; 0044; 0046; 0048; 0050; 0052; 0054; 0056

Benzo[b]thiophene, 2-[(5-broMo-2-fluorophenyl)Methyl]- Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Benzo[b]thiophene, 2-[(5-broMo-2-fluorophenyl)Methyl]- manufacturers

Nanjing Fred Technology Co., Ltd

Product: Benzo[b]thiophene, 2-[(5-broMo-2-fluorophenyl)Methyl]- 1034305-17-3
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1 ton
Release date: 2024-01-03

Qiuxian Baitai New Material Co., LTD

Product: 2-[(5-broMo-2-fluorophenyl)Methyl]-Benzo[b]thiophene 1034305-17-3
Price: US $0.00/KG
Min. Order: 1KG
Purity: ≥98%
Supply Ability: 20 tons
Release date: 2021-03-11

Career Henan Chemical Co

Product: Benzo[b]thiophene, 2-[(5-broMo-2-fluorophenyl)Methyl]- 1034305-17-3
Price: US $7.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 100KG
Release date: 2018-12-16

1034305-17-3, Benzo[b]thiophene, 2-[(5-broMo-2-fluorophenyl)Methyl]-Related Search:

L-Proline compd. with (1S)-1,5-anhydro-1-C-[3-(benzo[b]thien-2-ylmethyl)-4-fluorophenyl]-D-glucitol (1:1) Benzo[b]thiophene-2-Methanol, α-(5-broMo-2-fluorophenyl)- Methyl 1-C-[3-(benzo[b]thien-2-ylMethyl)-4-fluorophenyl]- Ipragliflozin 2-CHLORO-N-METHYL-N-(4-NITROPHENYL)ACETAMIDE Crizotinib 1-Chloro-2-(4-ethoxybenzyl)-4-iodobenzene (3S)-3-[4-[(5-Bromo-2-chlorophenyl)methyl]phenoxy]tetrahydrofuran (2-Chloro-5-iodophenyl)[4-[[(3S)-tetrahydro-3-furanyl]oxy]phenyl]methanone (2S,3R,4S,5S,6R)-2-(3-(4-((S)-tetrahydrofuran-3-yloxy)benzyl)-4-chlorophenyl)-tetrahydro-6-(hydroxyMethyl)-2-Methoxy-2H-pyran-3,4,5-triol 2,3,4,6-Tetra-O-benzyl-a-D-glucopyranosylbromide (S)-3-(4-(2-Chloro-5-iodobenzyl)phenoxy)tetrahydrofuran (2-Chloro-5-iodophenyl)(4-fluorophenyl)methanone 2,3,4,6-TETRA-O-PIVALOYL-ALPHA-D-GLUCOPYRANOSYL BROMIDE

Ipragliflozin-004

Ipragliflozin Impurity B

2-(5-BroMo-2-fluorobenzyl)benzo[b]thiophene

2-(5-bromo-2-fluorobenzyl)-1-benzothiophene

2-[(5-bromo-2-fluorophenyl)methyl]-1-benzothiophene

Ipragliflozin impurity B (B4)

2-[(5-broMo-2-fluorophenyl)Methyl]-

Ipragliflozin intermediate 1

Benzo[b]thiophene, 2-[(5-broMo-2-fluorophenyl)Methyl]-

2-(5-BroMo-2-fluorobenzyl)benzothiophene

2-[(5-bromo-2-fluorophenyl)Methyl]-Benzo[b]thiophene

Benzo[b]thiophene, 2-[(5-broMo-2-fluorophenyl)Methyl]- ISO 9001：2015 REACH

Azilsartan Impurity 64

Ipragliflozin Impurity 9

2-(5-Eromo-2-fluorobenzyl)benzobthiophene

1034305-17-3

C15H10BrFS