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Benzo[b]thiophene, 2-[(5-broMo-2-fluorophenyl)Methyl]-

Product Name
Benzo[b]thiophene, 2-[(5-broMo-2-fluorophenyl)Methyl]-
CAS No.
1034305-17-3
Chemical Name
Benzo[b]thiophene, 2-[(5-broMo-2-fluorophenyl)Methyl]-
Synonyms
2-(5-BroMo-2-fluorobenzyl)benzothiophene;2-(5-BroMo-2-fluorobenzyl)benzo[b]thiophene;Ipragliflozin-004;Azilsartan Impurity 64;Ipragliflozin Impurity B;Ipragliflozin Impurity 9;Ipragliflozin intermediate 1;Ipragliflozin impurity B (B4);2-[(5-broMo-2-fluorophenyl)Methyl]-;2-(5-Eromo-2-fluorobenzyl)benzobthiophene
CBNumber
CB82652155
Molecular Formula
C15H10BrFS
Formula Weight
321.21
MOL File
1034305-17-3.mol
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Benzo[b]thiophene, 2-[(5-broMo-2-fluorophenyl)Methyl]- Property

Boiling point:
408.9±35.0 °C(Predicted)
Density 
1.509±0.06 g/cm3(Predicted)
storage temp. 
2-8°C(protect from light)
Appearance
White to off-white Solid
InChI
InChI=1S/C15H10BrFS/c16-12-5-6-14(17)11(7-12)9-13-8-10-3-1-2-4-15(10)18-13/h1-8H,9H2
InChIKey
IKGTVOQAJKYBGO-UHFFFAOYSA-N
SMILES
C12=CC=CC=C1C=C(CC1=CC(Br)=CC=C1F)S2
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC
Product number
B961545
Product name
2-(5-Bromo-2-fluorobenzyl)benzo[b]thiophene
Packaging
100mg
Price
$175
Updated
2021/12/16
TRC
Product number
B961545
Product name
2-(5-Bromo-2-fluorobenzyl)benzo[b]thiophene
Packaging
50mg
Price
$110
Updated
2021/12/16
AK Scientific
Product number
3115AH
Product name
2-(5-Bromo-2-fluorobenzyl)benzo[B]thiophene
Packaging
1g
Price
$123
Updated
2021/12/16
Ambeed
Product number
A111765
Product name
2-(5-Bromo-2-fluorobenzyl)benzo[b]thiophene
Purity
97%
Packaging
5g
Price
$153
Updated
2021/12/16
Chemenu
Product number
CM130309
Product name
2-(5-Bromo-2-fluorobenzyl)benzo[b]thiophene
Purity
95%+
Packaging
5g
Price
$205
Updated
2021/12/16
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Benzo[b]thiophene, 2-[(5-broMo-2-fluorophenyl)Methyl]- Chemical Properties,Usage,Production

Synthesis

1034305-11-7

1034305-17-3

General procedure for the synthesis of 2-(5-bromo-2-fluorobenzyl)benzo[b]thiophene from benzo[b]thiophen-2-yl(5-bromo-2-fluorophenyl)methanol: 35.4 g (105 mmol) of benzo[b]thiophene-2-yl(5-bromo-2-fluorophenyl)methanol, a compound of Formula 3, was dissolved in 800 mL of dichloromethane, and the solution was cooled to -20 °C. To this solution, 36.5 mL (230 mmol) of triethylsilane and 15.2 mL (120 mmol) of boron trifluoride ethyl ether compound were slowly added under stirring. The reaction mixture was kept stirred at -20°C for 30 minutes. Upon completion of the reaction, saturated aqueous sodium bicarbonate solution was added to the mixture to neutralize the reaction. The organic phase was separated, dried with anhydrous magnesium sulfate, filtered and concentrated under reduced pressure to remove the solvent. The resulting crude product was purified by column chromatography (eluent: ethyl acetate/hexane mixed solvent) to afford the target product 2-(5-bromo-2-fluorobenzyl)benzo[b]thiophene (Compound 4) 30.4 g, with 99.5% purity and 90.1% yield.

References

[1] Patent: CN108276396, 2018, A. Location in patent: Paragraph 0041; 0048; 0049; 0064; 0079
[2] Bioorganic and Medicinal Chemistry, 2012, vol. 20, # 10, p. 3263 - 3279
[3] Patent: CN108623558, 2018, A. Location in patent: Paragraph 0042; 0044; 0046; 0048; 0050; 0052; 0054; 0056

Benzo[b]thiophene, 2-[(5-broMo-2-fluorophenyl)Methyl]- Preparation Products And Raw materials

Raw materials

Preparation Products

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Benzo[b]thiophene, 2-[(5-broMo-2-fluorophenyl)Methyl]- Suppliers

China 162 India 3 United Kingdom 1 United States 1 Global 167
A.J Chemicals
Tel
--
Fax
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Email
sales@ajchem.in
Country
India
ProdList
6100
Advantage
58
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View Lastest Price from Benzo[b]thiophene, 2-[(5-broMo-2-fluorophenyl)Methyl]- manufacturers

Nanjing Fred Technology Co., Ltd
Product
Benzo[b]thiophene, 2-[(5-broMo-2-fluorophenyl)Methyl]- 1034305-17-3
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1 ton
Release date
2024-01-03
Qiuxian Baitai New Material Co., LTD
Product
2-[(5-broMo-2-fluorophenyl)Methyl]-Benzo[b]thiophene 1034305-17-3
Price
US $0.00/KG
Min. Order
1KG
Purity
≥98%
Supply Ability
20 tons
Release date
2021-03-11
Career Henan Chemical Co
Product
Benzo[b]thiophene, 2-[(5-broMo-2-fluorophenyl)Methyl]- 1034305-17-3
Price
US $7.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
100KG
Release date
2018-12-16

1034305-17-3, Benzo[b]thiophene, 2-[(5-broMo-2-fluorophenyl)Methyl]-Related Search:

L-Proline compd. with (1S)-1,5-anhydro-1-C-[3-(benzo[b]thien-2-ylmethyl)-4-fluorophenyl]-D-glucitol (1:1) Benzo[b]thiophene-2-Methanol, α-(5-broMo-2-fluorophenyl)- Methyl 1-C-[3-(benzo[b]thien-2-ylMethyl)-4-fluorophenyl]- Ipragliflozin 2-CHLORO-N-METHYL-N-(4-NITROPHENYL)ACETAMIDE Crizotinib 1-Chloro-2-(4-ethoxybenzyl)-4-iodobenzene (3S)-3-[4-[(5-Bromo-2-chlorophenyl)methyl]phenoxy]tetrahydrofuran (2-Chloro-5-iodophenyl)[4-[[(3S)-tetrahydro-3-furanyl]oxy]phenyl]methanone (2S,3R,4S,5S,6R)-2-(3-(4-((S)-tetrahydrofuran-3-yloxy)benzyl)-4-chlorophenyl)-tetrahydro-6-(hydroxyMethyl)-2-Methoxy-2H-pyran-3,4,5-triol 2,3,4,6-Tetra-O-benzyl-a-D-glucopyranosylbromide (S)-3-(4-(2-Chloro-5-iodobenzyl)phenoxy)tetrahydrofuran (2-Chloro-5-iodophenyl)(4-fluorophenyl)methanone 2,3,4,6-TETRA-O-PIVALOYL-ALPHA-D-GLUCOPYRANOSYL BROMIDE

  • Ipragliflozin-004
  • Ipragliflozin Impurity B
  • 2-(5-BroMo-2-fluorobenzyl)benzo[b]thiophene
  • 2-(5-bromo-2-fluorobenzyl)-1-benzothiophene
  • 2-[(5-bromo-2-fluorophenyl)methyl]-1-benzothiophene
  • Ipragliflozin impurity B (B4)
  • 2-[(5-broMo-2-fluorophenyl)Methyl]-
  • Ipragliflozin intermediate 1
  • Benzo[b]thiophene, 2-[(5-broMo-2-fluorophenyl)Methyl]-
  • 2-(5-BroMo-2-fluorobenzyl)benzothiophene
  • 2-[(5-bromo-2-fluorophenyl)Methyl]-Benzo[b]thiophene
  • Benzo[b]thiophene, 2-[(5-broMo-2-fluorophenyl)Methyl]- ISO 9001：2015 REACH
  • Azilsartan Impurity 64
  • Ipragliflozin Impurity 9
  • 2-(5-Eromo-2-fluorobenzyl)benzobthiophene
  • 1034305-17-3
  • C15H10BrFS