ChemicalBook > CAS DataBase List > ME0328

ME0328

Product Name: ME0328
CAS No.: 1445251-22-8
Chemical Name: ME0328
Synonyms: ME0328;ME0328 ，S7438;ME0328 ME-0328;ME0328 USP/EP/BP;4-Dihydro-4-oxo-3;ME0328, 10 mM in DMSO;ME0328; ME 0328; ME-0328;ME 0328, PARP-3 inhibitor;4-Dihydro-4-oxo-N-[(1S)-1-phenylethyl]-2-quinazolinepropanamide;(S)-3,4-Dihydro-4-oxo-N-(1-phenylethyl)-2-quinazolinepropanamide
CBNumber: CB82705099
Molecular Formula: C19H19N3O2
Formula Weight: 321.37
MOL File: 1445251-22-8.mol

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ME0328 Property

storage temp.: Inert atmosphere,Store in freezer, under -20°C
solubility: DMSO: soluble10mg/mL, clear
form: powder
color: white to beige
Stability:: Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.

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Safety

Hazard Codes: Xn
Risk Statements: 22-43
Safety Statements: 36/37
WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML0999
Product name: ME0328
Purity: ≥98% (HPLC)
Packaging: 5mg
Price: $88.4
Updated: 2025/07/31

Sigma-Aldrich

Product number: SML0999
Product name: ME0328
Purity: ≥98% (HPLC)
Packaging: 25mg
Price: $527
Updated: 2022/05/15

Cayman Chemical

Product number: 18488
Product name: ME0328
Purity: ≥98%
Packaging: 1mg
Price: $38
Updated: 2024/03/01

Cayman Chemical

Product number: 18488
Product name: ME0328
Purity: ≥98%
Packaging: 5mg
Price: $85
Updated: 2024/03/01

Cayman Chemical

Product number: 18488
Product name: ME0328
Purity: ≥98%
Packaging: 10mg
Price: $111
Updated: 2024/03/01

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ME0328 Chemical Properties,Usage,Production

Description

The poly(ADP-ribose) polymerases (PARPs) are enzymes with roles in DNA repair, apoptosis, inflammation, and other cellular events, particularly in response to reactive oxygen and nitrogen species. ME0328 is an inhibitor of PARP3 (IC₅₀ = 0.89 μM), which is a regulator of DNA repair and mitotic progression. It displays selectivity for PARP3 over 12 other PARP family members. ME0328 is cell permeable and elicits PARP3-specific effects at submicromolar concentrations.

Uses

ME0328 is a potent poly ADP ribose polymerase (PARP) inhibitor with selectivity towards the human ADP-Ribosyltransferase ARTD3/PARP3.

IC 50

ARTD3/PARP3: 0.89 μM (IC₅₀); ARTD1/PARP1: 6.3 μM (IC₅₀); ARTD2/PARP2: 10.8 μM (IC₅₀); ARTD6/TNKS2: 34.3 μM (IC₅₀); ARTD5/TNKS1: 47.3 μM (IC₅₀); ARTD10/PARP10: 71.3 μM (IC₅₀)

References

[1] ANDERS E. G. LINDGREN. PARP Inhibitor with Selectivity Toward ADP-Ribosyltransferase ARTD3/PARP3[J]. ACS Chemical Biology, 2013, 8 8: 1698-1703. DOI:10.1021/cb4002014

ME0328 Preparation Products And Raw materials

Raw materials

Preparation Products

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ME0328 Suppliers

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View Lastest Price from ME0328 manufacturers

Career Henan Chemical Co

Product: ME0328 1445251-22-8
Price: US $1.00/g
Min. Order: 1g
Purity: 99%
Supply Ability: 200kg
Release date: 2019-12-25

1445251-22-8, ME0328Related Search:

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ME0328; ME 0328; ME-0328

4-Dihydro-4-oxo-3

4-Dihydro-4-oxo-N-[(1S)-1-phenylethyl]-2-quinazolinepropanamide

ME0328

3,4-Dihydro-4-oxo-3,4-Dihydro-4-oxo-N-[(1S)-1-phenylethyl]-2-quinazolinepropanamide

(S)-3,4-Dihydro-4-oxo-N-(1-phenylethyl)-2-quinazolinepropanamide

2-Quinazolinepropanamide, 3,4-dihydro-4-oxo-N-[(1S)-1-phenylethyl]-

ME0328 USP/EP/BP

ME0328 ME-0328

(S)-3-(4-Oxo-3,4-dihydroquinazolin-2-yl)-N-(1-phenylethyl)propanamide

ME 0328, PARP-3 inhibitor

ME0328, 10 mM in DMSO

ME0328 ，S7438

1445251-22-8

Inhibitors