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ME0328

Product Name
ME0328
CAS No.
1445251-22-8
Chemical Name
ME0328
Synonyms
ME0328;ME0328 ME-0328;ME0328 USP/EP/BP;4-Dihydro-4-oxo-3;ME0328; ME 0328; ME-0328;4-Dihydro-4-oxo-N-[(1S)-1-phenylethyl]-2-quinazolinepropanamide;(S)-3,4-Dihydro-4-oxo-N-(1-phenylethyl)-2-quinazolinepropanamide;2-Quinazolinepropanamide, 3,4-dihydro-4-oxo-N-[(1S)-1-phenylethyl]-;(S)-3-(4-Oxo-3,4-dihydroquinazolin-2-yl)-N-(1-phenylethyl)propanamide;3,4-Dihydro-4-oxo-3,4-Dihydro-4-oxo-N-[(1S)-1-phenylethyl]-2-quinazolinepropanamide
CBNumber
CB82705099
Molecular Formula
C19H19N3O2
Formula Weight
321.37
MOL File
1445251-22-8.mol
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ME0328 Property

storage temp. 
Inert atmosphere,Store in freezer, under -20°C
solubility 
DMSO: soluble10mg/mL, clear
form 
powder
color 
white to beige
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
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Safety

Hazard Codes 
Xn
Risk Statements 
22-43
Safety Statements 
36/37
WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML0999
Product name
ME0328
Purity
≥98% (HPLC)
Packaging
5mg
Price
$119
Updated
2024/03/01
Sigma-Aldrich
Product number
SML0999
Product name
ME0328
Purity
≥98% (HPLC)
Packaging
25mg
Price
$527
Updated
2022/05/15
Cayman Chemical
Product number
18488
Product name
ME0328
Purity
≥98%
Packaging
1mg
Price
$38
Updated
2024/03/01
Cayman Chemical
Product number
18488
Product name
ME0328
Purity
≥98%
Packaging
5mg
Price
$85
Updated
2024/03/01
Cayman Chemical
Product number
18488
Product name
ME0328
Purity
≥98%
Packaging
10mg
Price
$111
Updated
2024/03/01
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ME0328 Chemical Properties,Usage,Production

Description

The poly(ADP-ribose) polymerases (PARPs) are enzymes with roles in DNA repair, apoptosis, inflammation, and other cellular events, particularly in response to reactive oxygen and nitrogen species. ME0328 is an inhibitor of PARP3 (IC50 = 0.89 μM), which is a regulator of DNA repair and mitotic progression. It displays selectivity for PARP3 over 12 other PARP family members. ME0328 is cell permeable and elicits PARP3-specific effects at submicromolar concentrations.

Uses

ME0328 is a potent poly ADP ribose polymerase (PARP) inhibitor with selectivity towards the human ADP-Ribosyltransferase ARTD3/PARP3.

References

1) Lindgren?et al. (2013),?PARP Inhibitor with Selectivity Toward ADP-Ribosyltransferase ART3/PARP3; ACS Chem. Biol.,8?1689

ME0328 Preparation Products And Raw materials

Raw materials

Preparation Products

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ME0328 Suppliers

China 88 India 1 United Kingdom 1 United States 13 Global 103
A.J Chemicals
Tel
--
Fax
--
Email
sales@ajchem.in
Country
India
ProdList
6100
Advantage
58
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View Lastest Price from ME0328 manufacturers

Career Henan Chemical Co
Product
ME0328 1445251-22-8
Price
US $1.00/g
Min. Order
1g
Purity
99%
Supply Ability
200kg
Release date
2019-12-25

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  • ME0328; ME 0328; ME-0328
  • 4-Dihydro-4-oxo-3
  • 4-Dihydro-4-oxo-N-[(1S)-1-phenylethyl]-2-quinazolinepropanamide
  • ME0328
  • 3,4-Dihydro-4-oxo-3,4-Dihydro-4-oxo-N-[(1S)-1-phenylethyl]-2-quinazolinepropanamide
  • (S)-3,4-Dihydro-4-oxo-N-(1-phenylethyl)-2-quinazolinepropanamide
  • 2-Quinazolinepropanamide, 3,4-dihydro-4-oxo-N-[(1S)-1-phenylethyl]-
  • ME0328 USP/EP/BP
  • ME0328 ME-0328
  • (S)-3-(4-Oxo-3,4-dihydroquinazolin-2-yl)-N-(1-phenylethyl)propanamide
  • 1445251-22-8
  • Inhibitors