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CYCLO(-HIS-PRO)

Product Name
CYCLO(-HIS-PRO)
CAS No.
53109-32-3
Chemical Name
CYCLO(-HIS-PRO)
Synonyms
Cyclo(HP);Cyclo(Pro-His);CYCLO(-HIS-PRO);HIS-PRO, CYCLIC;Cyclo-Pro-His-HO;CYCLO(HIS-PRO), >99%;Vitamin B6 Impurity 93;Cyclo(histidyl-proline);Protirelin EP Impurity E;Cyclo(L-histidyl-L-proline)
CBNumber
CB8279260
Molecular Formula
C11H14N4O2
Formula Weight
234.25
MOL File
53109-32-3.mol
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CYCLO(-HIS-PRO) Property

Melting point:
162-164 °C
Boiling point:
659.3±48.0 °C(Predicted)
Density 
1.41±0.1 g/cm3(Predicted)
storage temp. 
2-8°C
solubility 
DMF: 1 mg/ml; DMSO: 1 mg/ml; Ethanol: 1 mg/ml; PBS (pH 7.2): 1 mg/ml
form 
A neat oil
pka
12.73±0.40(Predicted)
color 
Light yellow to yellow
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Safety

WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Biosynth Carbosynth
Product number
FC49257
Product name
Cyclo(L-His-L-Pro)
Packaging
25mg
Price
$83.5
Updated
2021/12/16
ChemScene
Product number
CS-6320
Product name
Cyclo(his-pro)
Packaging
5mg
Price
$90
Updated
2021/12/16
Biosynth Carbosynth
Product number
FC49257
Product name
Cyclo(L-His-L-Pro)
Packaging
50mg
Price
$140.5
Updated
2021/12/16
ChemScene
Product number
CS-6320
Product name
Cyclo(his-pro)
Packaging
10mg
Price
$150
Updated
2021/12/16
Biosynth Carbosynth
Product number
FC49257
Product name
Cyclo(L-His-L-Pro)
Packaging
100mg
Price
$225
Updated
2021/12/16
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CYCLO(-HIS-PRO) Chemical Properties,Usage,Production

Uses

Cyclo(L-histidyl-L-proline) is used in the pharmaceutical composition comprising cyclo(His-Pro) for preventing or treating obesity.

Definition

ChEBI: Cyclo(L-His-L-Pro) is a homodetic cyclic peptide resulting from the formal condensation of both the amino and acid groups of L-histidine with the acid and amino groups of L-proline. It is a metabolite of thyrotropin-releasing hormone (TRH). It has a role as a human blood serum metabolite, a dopamine uptake inhibitor and an anti-inflammatory agent. It is a homodetic cyclic peptide, a dipeptide, a pyrrolopyrazine and a member of imidazoles. It is functionally related to a L-histidine and a L-proline.

CYCLO(-HIS-PRO) Preparation Products And Raw materials

Raw materials

Preparation Products

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CYCLO(-HIS-PRO) Suppliers

China 71 France 1 Germany 1 India 2 Switzerland 1 United Kingdom 1 United States 9 Global 86
Pharmaffiliates Analytics and Synthetics P. Ltd
Tel
--
Fax
--
Email
mktg@pharmaffiliates.com
Country
India
ProdList
6739
Advantage
58

53109-32-3, CYCLO(-HIS-PRO)Related Search:

2,5-Dimethylpiperazine 1-Methylpiperazin-2-one DL-2-AMINOPROPIONIC ANHYDRIDE CYCLO(-ALA-ALA) CIS-2,5-DIMETHYLPIPERAZINE CYCLO-(D-PRO-L-ALA-D-ALA-L-2-AMINO-8-OXO-9,10-EPOXYDECANOIC ACID),Cyclo[D-Pro-L-Ala-D-Ala-2-(6-oxo-6-oxiranylhexyl)-L-Gly-] Cyclo(L-Pro-L-Val-) CYCLO(-GLY-HIS) 1-ETHYL-2-METHYL-PIPERAZINE CYCLO(-GLY-PRO) (S)-3-METHYL-2-KETOPIPERAZINE CYCLO(-ALA-GLY) HEXAHYDROPYRROLO[1,2-A]PYRAZINE-1,4-DIONE (+/-)-1,4-DIAZABICYCLO[4.4.0]DECANE (R)-HEXAHYDROPYRROLO[1,2-A]PYRAZIN-1(2H)-ONE 1-ETHYLPIPERAZIN-2-ONE hexahydropyrrolo[1,2-a]pyrazin-4(1H)-one (S)-1,4-DIAZABICYCLO[4.3.0]NONANE

  • (3S,6S)-3-(3H-imidazol-4-ylmethyl)-1,4-diazabicyclo[4.4.0]decane-2,5-dione
  • Histidylproline diketopiperazine
  • histidylproline dioxopiperazine
  • Cyclo-Pro-His-HO
  • HIS-PRO, CYCLIC
  • CYCLO(-HIS-PRO)
  • Cyclo(histidyl-proline)
  • CYCLO(HISTIDYL-PROLINE); HISTIDYLPROLINE DIKETOPIPERAZINE
  • CYCLO(HIS-PRO), >99%
  • Cyclo(his-pro),Cyclo(histidyl-proline),Histidylproline diketopiperazine, >99%
  • Protirelin EP Impurity E
  • Pyrrolo[1,2-a]pyrazine-1,4-dione, hexahydro-3-(1H-imidazol-4-ylmethyl)-, (3S,8aS)-
  • 3-(1H-imidazol-5-ylmethyl)-2,3,6,7,8,8a-hexahydropyrrolo[1,2-a]pyrazine-1,4-dione
  • Cyclo(L-histidyl-L-proline)
  • (3S,8aS)-3-(1H-Imidazol-4-ylmethyl)hexahydropyrrolo[1,2-a]pyrazine-1,4-dione
  • Cyclo(his-pro) (Cyclo(histidyl-proline))
  • Endogenous Metabolite,active,orally,inflammatory,inhibit,tyreotropin-releasing,stress,NF-κB,Cyclo(his-pro),hormone,Nuclear factor-κB,cyclic,Cyclo(hispro),Histidylproline diketopiperazine,Cyclo(histidyl-proline),dipeptide,Cyclo(his pro),Inhibitor,Nuclear factor-kappaB,responses
  • Cyclo(HP)
  • (3S,8aS)-3-[(4-Imidazolyl)methyl]hexahydropyrrolo[1,2-a]pyrazine-1,4-dione
  • Cyclo(Pro-His)
  • Vitamin B6 Impurity 93
  • Nebivolol Impurity 10 Monomer
  • 53109-32-3
  • Peptides
  • Releasing Factors
  • TRH
  • Biochemicals and Reagents
  • Amino Acids and Peptides
  • BioChemical