Methyl 1H-indazole-4-carboxylate
- Product Name
- Methyl 1H-indazole-4-carboxylate
- CAS No.
- 192945-49-6
- Chemical Name
- Methyl 1H-indazole-4-carboxylate
- Synonyms
- Methyl indazole-4-carboxy...;Methyl indazole-4-carboxylate;4-(Methoxycarbonyl)-1H-indazole;METHYL 1H-INDAZOLE-4-CARBOXYLATE;Methyl 1H-indazole-4-carboxylate;INDAZOLE-4-CARBOXYLIC ACID METHYL ESTER;4-(1H)INDAZOLE CARBOXYLIC ACID METHYL ESTER;1H-Indazole-4-carboxylic acid, Methyl ester;1(2)H-Indazole-4-Carboxylic Acid Methyl Ester
- CBNumber
- CB8308377
- Molecular Formula
- C9H8N2O2
- Formula Weight
- 176.17
- MOL File
- 192945-49-6.mol
Methyl 1H-indazole-4-carboxylate Property
- Melting point:
- 133-138°C
- Boiling point:
- 345.2±15.0 °C(Predicted)
- Density
- 1.324±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- form
- solid
- pka
- 12.43±0.40(Predicted)
- Appearance
- Off-white to yellow Solid
Safety
- WGK Germany
- 3
- HS Code
- 2933998090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P260Do not breathe dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
N-Bromosuccinimide Price
- Product number
- 729744
- Product name
- Methyl 1H-indazole-4-carboxylate
- Purity
- 97%
- Packaging
- 1g
- Price
- $97.5
- Updated
- 2023/06/20
- Product number
- M321298
- Product name
- Methyl 1H-indazole-4-carboxylate
- Packaging
- 100mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- 4H23-1-12
- Product name
- Methyl 1H-indazole-4-carboxylate
- Purity
- 98%
- Packaging
- 5G
- Price
- $45
- Updated
- 2021/12/16
- Product number
- 069833
- Product name
- 1H-Indazole-4-carboxylic acid methyl ester
- Purity
- 97%
- Packaging
- 500mg
- Price
- $13
- Updated
- 2021/12/16
- Product number
- 069833
- Product name
- 1H-Indazole-4-carboxylic acid methyl ester
- Purity
- 97%
- Packaging
- 1g
- Price
- $19
- Updated
- 2021/12/16
Methyl 1H-indazole-4-carboxylate Chemical Properties,Usage,Production
Synthesis
18583-89-6
192945-49-6
The general procedure for the synthesis of methyl indazole-4-carboxylate from methyl 3-amino-2-methylbenzoate was as follows: methyl 3-amino-2-methylbenzoate (0.3 g, 1.96 mmol) was dissolved in aqueous NaNO2 (0.62 g, 2 mmol), followed by the slow addition of dilute aqueous glacial acetic acid (7 mL, 3 mmol, the volume ratio of glacial acetic acid to water was 0.2:10). The reaction mixture was stirred at room temperature for 4-6 hours. After completion of the reaction, the reaction mixture was extracted with ethyl acetate (EtOAc) and the organic layer was washed with deionized water (2 x 10 mL). The organic layer was dried over anhydrous sodium sulfate (Na2SO4), concentrated under reduced pressure and purified by column chromatography to give the yellow powdery product indazole-4-carboxylic acid methyl ester. The yield was 0.22 g in 69%; the melting point was 153-155 °C. The product was purified by column chromatography. The 1H NMR (400 MHz, CDCl3, TMS as internal standard, δ in ppm) data of the product were as follows: δ2.55 (s, 3H), 7.37 (t, 1H, J=14.32 Hz), 7.53 (s, 1H), 7.67 (d, 1H, J=8.12 Hz), 7.82 (d, 1H, J=8.16 Hz), 9.79 (s, 1H).
References
[1] Patent: US2012/130078, 2012, A1. Location in patent: Page/Page column 4-5
[2] Patent: EP2141150, 2010, A1. Location in patent: Page/Page column 48
[3] Journal of Medicinal Chemistry, 2000, vol. 43, # 1, p. 41 - 58
[4] Asian Journal of Chemistry, 2014, vol. 26, # 7, p. 1921 - 1930
[5] Patent: WO2009/108838, 2009, A1. Location in patent: Page/Page column 104
Methyl 1H-indazole-4-carboxylate Preparation Products And Raw materials
Raw materials
Preparation Products
Methyl 1H-indazole-4-carboxylate Suppliers
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- Country
- India
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View Lastest Price from Methyl 1H-indazole-4-carboxylate manufacturers
- Product
- 4-(1H)INDAZOLE CARBOXYLIC ACID METHYL ESTER 192945-49-6
- Price
- US $8.80/KG
- Min. Order
- 1KG
- Purity
- 97%-99%
- Supply Ability
- 100kg
- Release date
- 2019-08-05