ChemicalBook > CAS DataBase List > 8-Quinolinesulfonyl chloride
8-Quinolinesulfonyl chloride
- Product Name
- 8-Quinolinesulfonyl chloride
- CAS No.
- 18704-37-5
- Chemical Name
- 8-Quinolinesulfonyl chloride
- Synonyms
- QUINOLINE-8-SULFONYL CHLORIDE;QSC;SKL275;AKOS B019400;ART-CHEM-BB B019400;8-Quinolinesulfonyl;8-quinolylsulfonylchloride;Chinolin-8-sulfonylchlorid;8-Quinolylsulfonyl chloride;8-Chlorosulfonyl-1-benzazine
- CBNumber
- CB8329163
- Molecular Formula
- C9H6ClNO2S
- Formula Weight
- 227.67
- MOL File
- 18704-37-5.mol
More
Less
8-Quinolinesulfonyl chloride Property
- Melting point:
- 126-129 °C(lit.)
- Boiling point:
- 306°C
- Density
- 1.483±0.06 g/cm3(Predicted)
- Flash point:
- 306°C
- storage temp.
- Inert atmosphere,2-8°C
- solubility
- methanol: soluble10mg/mL, clear, colorless to light yellow
- pka
- 0?+-.0.17(Predicted)
- form
- powder to crystal
- color
- White to Orange to Green
- Sensitive
- Moisture Sensitive
- BRN
- 156347
- InChI
- InChI=1S/C9H6ClNO2S/c10-14(12,13)8-5-1-3-7-4-2-6-11-9(7)8/h1-6H
- InChIKey
- JUYUYCIJACTHMK-UHFFFAOYSA-N
- SMILES
- N1C2C(=CC=CC=2S(Cl)(=O)=O)C=CC=1
- CAS DataBase Reference
- 18704-37-5(CAS DataBase Reference)
- NIST Chemistry Reference
- Sulfonyl chloride, 8-quinoline-(18704-37-5)
More
Less
Safety
- Hazard Codes
- C
- Risk Statements
- 34
- Safety Statements
- 26-36/37/39-45-27
- RIDADR
- UN 3261 8/PG 2
- WGK Germany
- 3
- RTECS
- VC2830000
- F
- 3-10-21
- HazardClass
- 8
- PackingGroup
- III
- HS Code
- 29334990
More
Less
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H314Causes severe skin burns and eye damage
- Precautionary statements
-
P260Do not breathe dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P363Wash contaminated clothing before reuse.
More
Less
N-Bromosuccinimide Price
Sigma-Aldrich
- Product number
- Q1506
- Product name
- 8-Quinolinesulfonyl chloride
- Purity
- 98%
- Packaging
- 5g
- Price
- $49.97
- Updated
- 2025/07/31
Sigma-Aldrich
- Product number
- 22695
- Product name
- 8-Quinolinesulfonyl chloride
- Purity
- ≥96.0% (AT)
- Packaging
- 5g
- Price
- $54
- Updated
- 2021/12/16
TCI Chemical
- Product number
- Q0016
- Product name
- Quinoline-8-sulfonyl Chloride
- Purity
- >98.0%(T)
- Packaging
- 5g
- Price
- $83
- Updated
- 2025/07/31
TCI Chemical
- Product number
- Q0016
- Product name
- Quinoline-8-sulfonyl Chloride
- Purity
- >98.0%(T)
- Packaging
- 25g
- Price
- $229
- Updated
- 2025/07/31
Sigma-Aldrich
- Product number
- Q1506
- Product name
- 8-Quinolinesulfonyl chloride
- Purity
- 98%
- Packaging
- 10g
- Price
- $69.93
- Updated
- 2025/07/31
More
Less
8-Quinolinesulfonyl chloride Chemical Properties,Usage,Production
Chemical Properties
white to light yellow crystal powder
Uses
8-Quinolinesulfonyl chloride was used as a coupling reagent in oligonucleotide synthesis. It was also used in the synthesis of olefins from secondary esters at moderate temperature
General Description
8-Quinolinesulfonyl chloride reacts with aromatic/heterocyclic sulfonamides containing a free amino, imino, hydrazino or hydroxyl group to form water-soluble compounds.
Synthesis
85-48-3
18704-37-5
The general procedure for the synthesis of quinoline-8-sulfonyl chloride from quinoline-8-sulfonic acid is as follows: chlorosulfonic acid (6.0 g, 51.5 mmol) was added to a reaction vessel fitted with a magnetic stirrer under nitrogen protection. Quinoline (1.0 g, 7.74 mmol) was slowly added under cooling in an ice bath. Subsequently, the reaction system was gradually warmed to 140 °C and the reaction was continuously stirred at this temperature for 10 hours. Upon completion of the reaction, the system was cooled to 40 °C and thionyl chloride (2.0 g, 16.0 mmol) was added dropwise. Then, the reaction temperature was raised to 70 °C and the reaction continued to be stirred for 4 hours. At the end of the reaction, the reaction system was allowed to cool naturally to room temperature, and the reaction solution was slowly poured into ice water, which immediately precipitated a solid. After stirring the mixture for 30 min, the solid product was collected by filtration and dried under vacuum to give quinoline-8-sulfonyl chloride (1.7 g, 99% yield). Mass spectrometry analysis showed m/z: 228.0 (M+1).
References
[1] Patent: WO2018/156297, 2018, A1. Location in patent: Paragraph 0101; 0114; 0115; 0116; 0117
[2] Synthesis, 2004, # 18, p. 2999 - 3004
[3] Chemische Berichte, 1908, vol. 41, p. 942
[4] Chemische Berichte, 1886, vol. 19, p. 925
8-Quinolinesulfonyl chloride Preparation Products And Raw materials
Raw materials
Preparation Products
More
Less
8-Quinolinesulfonyl chloride Suppliers
- Tel
- 0512-69209928 18796809688
- Fax
- 0512-68417696
- zhouyingxiang@highfine.com
- Country
- China
- ProdList
- 475
- Advantage
- 75
- Tel
- 18210857532; 18210857532
- Fax
- 86-10-82849933
- jkinfo@jkchemical.com
- Country
- China
- ProdList
- 96815
- Advantage
- 76
- Tel
- 4006356688 18621169109
- Fax
- 86-21-61259102
- market03@meryer.com
- Country
- China
- ProdList
- 40228
- Advantage
- 62
- Tel
- +86-21-20908456
- Fax
- 021-58180499
- sales@BioChemBest.com
- Country
- China
- ProdList
- 6003
- Advantage
- 61
- Tel
- 400-6106006
- Fax
- 021-67582001/03/05
- saleschina@alfa-asia.com
- Country
- China
- ProdList
- 30123
- Advantage
- 84
- Tel
- 021-67121386
- Fax
- 021-67121385
- Sales-CN@TCIchemicals.com
- Country
- China
- ProdList
- 24529
- Advantage
- 81
- Tel
- 021-021-58432009 400-005-6266
- Fax
- 021-58436166
- sales8178@energy-chemical.com
- Country
- China
- ProdList
- 44801
- Advantage
- 61
- Tel
- +86 (0) 571 85 58 67 18
- Fax
- 0086-571-85864795
- Country
- China
- ProdList
- 18207
- Advantage
- 66
- Tel
- 0573-85285100 18627885956
- Fax
- 0573-85285100
- isenchem@163.com
- Country
- China
- ProdList
- 9310
- Advantage
- 66
- Tel
- 021-50795510 4000665055
- Fax
- 021-50795055
- sales@accelachem.com
- Country
- China
- ProdList
- 11035
- Advantage
- 64
- Tel
- 021-54306202 13764082696
- info@hanhongsci.com
- Country
- China
- ProdList
- 42934
- Advantage
- 64
- Tel
- 4009903999 13355009207
- Fax
- 0539-6365991
- 3007715519@qq.com
- Country
- China
- ProdList
- 18729
- Advantage
- 57
- Tel
- 0086-21-58956006
- Fax
- 0086-21-58956100
- Country
- China
- ProdList
- 7811
- Advantage
- 57
- Tel
- 0571-82693216
- Fax
- +86-571-82880190
- info@yuhaochemical.com
- Country
- China
- ProdList
- 6387
- Advantage
- 52
- Tel
- 0370-2785118 17550508557
- Fax
- QQ：3470079902
- 675141927@qq.com
- Country
- China
- ProdList
- 3199
- Advantage
- 55
- Tel
- 021-58388037;21-58388037 13472507714
- 35177634@qq.com;1589045147@qq.com
- Country
- China
- ProdList
- 803
- Advantage
- 55
- Tel
- 4008-755-333 18080918076
- Fax
- 028-86757656
- 800078821@qq.com
- Country
- China
- ProdList
- 9718
- Advantage
- 55
- Tel
- 86-21-34053660
- Fax
- 86-21-34053661
- sale@labgogo.com
- Country
- China
- ProdList
- 9865
- Advantage
- 52
- Tel
- 4009209199
- Fax
- 86-021-52271987
- sales@9dingchem.com
- Country
- China
- ProdList
- 18209
- Advantage
- 56
- Tel
- 400-6206333 13167063860
- Fax
- 021-50323701
- anhua.mao@aladdin-e.com
- Country
- China
- ProdList
- 25003
- Advantage
- 65
- Tel
- 86-0755-86635001
- Fax
- 86-0755-22642228
- cantotech@126.com
- Country
- China
- ProdList
- 4566
- Advantage
- 55
- Tel
- 021-62960152
- Fax
- 021-52212593
- 934678158@qq.com
- Country
- China
- ProdList
- 9899
- Advantage
- 55
- Tel
- 021-61119791,13386096464
- Fax
- 021-50190009
- bzswkf@foxmail.com
- Country
- China
- ProdList
- 3921
- Advantage
- 50
- Tel
- 13971561712, 13995564702, 027-50664929
- Fax
- 027-50664927
- hbeixys2001@163.com
- Country
- China
- ProdList
- 3120
- Advantage
- 55
- Tel
- 0554-2106669
- Fax
- 0554-2666215
- sales1@kedichem.com
- Country
- China
- ProdList
- 4924
- Advantage
- 55
- Tel
- 400-164-7117 13681763483
- Fax
- +86-21-61629029
- product02@bidepharm.com
- Country
- China
- ProdList
- 39966
- Advantage
- 60
- Tel
- 0371-0371-13526885213 15637198702
- Fax
- 0371-63709726
- hsyykjchem@163.com
- Country
- China
- ProdList
- 3853
- Advantage
- 58
- Tel
- 021-021-56795766
- Fax
- +86-21-56795266
- sales@worldyachem.com
- Country
- China
- ProdList
- 9476
- Advantage
- 58
- Tel
- 400-1166-196 13458535857
- Fax
- QQ：800101999
- cdhxsj@163.com
- Country
- China
- ProdList
- 13350
- Advantage
- 58
- Tel
- 0512-87182056 18013166090
- Fax
- 0512-87182056
- lingling.qi@yacoo.com.cn
- Country
- China
- ProdList
- 6295
- Advantage
- 60
- Tel
- 15121041756
- xingui2022@126.com
- Country
- China
- ProdList
- 9979
- Advantage
- 58
- Tel
- 010-1234567 18521000990
- Fax
- 86-021-33275113
- sonyuanchemical@163.com
- Country
- China
- ProdList
- 6479
- Advantage
- 50
- Tel
- 025-66028182 18626450290
- yftan@aikonchem.com
- Country
- China
- ProdList
- 16679
- Advantage
- 50
- Tel
- 028-028-60651388 13330964498
- slyu@hengkangtech.com
- Country
- China
- ProdList
- 378
- Advantage
- 58
- Tel
- 021-61415566 800-8193336
- orderCN@merckgroup.com
- Country
- China
- ProdList
- 51395
- Advantage
- 80
- Tel
- 0371-53765687 18937137882
- Fax
- QQ:2885373884
- 2853979813@qq.com
- Country
- China
- ProdList
- 7991
- Advantage
- 55
- Tel
- 18620099427
- Fax
- +86-20-62619665
- amy@howeipharm.com
- Country
- China
- ProdList
- 6687
- Advantage
- 55
- Tel
- 021-58892003
- info@qiaochem.com
- Country
- China
- ProdList
- 6059
- Advantage
- 65
- Tel
- 0311-89250318 031166536426
- Fax
- 4000311741
- master@sjzsdyn.com
- Country
- China
- ProdList
- 3495
- Advantage
- 58
- Tel
- 021-61312847; 18021002903
- Fax
- QQ:3008007432
- 3008007409@qq.com
- Country
- China
- ProdList
- 71826
- Advantage
- 60
- Tel
- 022-83705301 13752403750
- Fax
- 022-83705301
- 2966024760@qq.com
- Country
- China
- ProdList
- 873
- Advantage
- 55
- Tel
- 4009903999 13395398332
- Fax
- 0539-6365991
- sales@xiyashiji.com
- Country
- China
- ProdList
- 20794
- Advantage
- 60
- Tel
- 18221735425
- sales@xinpingchem.com
- Country
- China
- ProdList
- 9942
- Advantage
- 58
- Tel
- 15738884691 153248764872949584887 237654463
- Fax
- 0371-55320919
- jiuhuabiochem@163.com
- Country
- China
- ProdList
- 2750
- Advantage
- 58
- Tel
- 571-89925085
- Fax
- 0086-571-89925065
- sales@amadischem.com
- Country
- China
- ProdList
- 131957
- Advantage
- 58
- Tel
- 0751-2886750 13927877953
- Fax
- 0751-2886750
- 3005811397@qq.com
- Country
- China
- ProdList
- 13305
- Advantage
- 58
- Tel
- 0539-6362799 20）
- Fax
- 0539-6362799（To 20）
- Country
- China
- ProdList
- 9998
- Advantage
- 58
- Tel
- 021-33922791-0 13816046603
- 3368239663@qq.com
- Country
- China
- ProdList
- 4287
- Advantage
- 58
- Tel
- 021-37581181
- Fax
- 021-57456066
- sales@chem-mall.com
- Country
- China
- ProdList
- 10330
- Advantage
- 58
- Tel
- 021-16621358918; 18516310516
- Fax
- 13045646768
- zhenlipharma888@163.com
- Country
- China
- ProdList
- 19035
- Advantage
- 58
More
Less
View Lastest Price from 8-Quinolinesulfonyl chloride manufacturers
Henan Aochuang Chemical Co.,Ltd.
- Product
- 8-Quinolinesulfonyl chloride 18704-37-5
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 1ton
- Release date
- 2022-09-28
Changzhou waston chemical technology Co.,Ltd
- Product
- 8-Quinolinesulfonyl chloride 18704-37-5
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 95%,97%
- Supply Ability
- As your request
- Release date
- 2025-03-19
Shaanxi Dideu New Materials Co. Ltd
- Product
- 8-Quinolinesulfonyl chloride 18704-37-5
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 98.0%
- Supply Ability
- 10000KGS
- Release date
- 2025-02-28
18704-37-5, 8-Quinolinesulfonyl chlorideRelated Search:
Oxalyl chloride
Sulfuryl chloride
Quinoline Yellow
Ethanesulfonyl chloride
Zinc chloride
3-Methyl-8-quinolinesulphonyl chloride
N-Acetylsulfanilyl chloride
Sodium chloride
Benzenesulfonyl chloride
Calcium chloride
Thionyl chloride
4-Nitrobenzenesulfonyl chloride
Quinoline
Ammonium chloride
Choline chloride
Tosyl chloride
Potassium chloride
3-QUINOLINEBORONIC ACID HYDROCHLORIDE