ChemicalBook > CAS DataBase List > Ethyl trifluoropyruvate

Ethyl trifluoropyruvate

Product Name
Ethyl trifluoropyruvate
CAS No.
13081-18-0
Chemical Name
Ethyl trifluoropyruvate
Synonyms
ETHYL 3,3,3-TRIFLUORO-2-OXOPROPANOATE;ETHYL 3,3,3-TRIFLUOROPYRUVATE;E-TFPA;RARECHEM AL BI 1300;ETHYL TRIFLUOROPYRUVATE;Ethyltrifluoropyruvate98%;ETHYL 3,3,3-TRIFLUORO-2-O;Threefluorideethylpyruvate;Ethyl trifluoropyruvate 98%;Ethyl-trifluoroMethylpyruvate
CBNumber
CB8333735
Molecular Formula
C5H5F3O3
Formula Weight
170.09
MOL File
13081-18-0.mol
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Ethyl trifluoropyruvate Property

Boiling point:
42 °C(lit.)
Density 
1.283 g/mL at 25 °C (lit.)
vapor pressure 
12.49hPa at 25℃
refractive index 
n20/D 1.341(lit.)
Flash point:
88 °F
storage temp. 
Inert atmosphere,2-8°C
solubility 
Miscible with dichloromethane.
form 
Liquid
color 
Clear colorless to pale yellow
BRN 
2087388
Stability:
Moisture Sensitive
InChIKey
KJHQVUNUOIEYSV-UHFFFAOYSA-N
LogP
-0.05
CAS DataBase Reference
13081-18-0(CAS DataBase Reference)
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Safety

Hazard Codes 
Xn,C,Xi
Risk Statements 
10-22-36/37/38
Safety Statements 
26-37/39-16
RIDADR 
UN 3272 3/PG 3
WGK Germany 
3
Hazard Note 
Corrosive
HazardClass 
3
PackingGroup 
III
HS Code 
29183000
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H226Flammable liquid and vapour

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P233Keep container tightly closed.

P240Ground/bond container and receiving equipment.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
510254
Product name
Ethyl 3,3,3-trifluoropyruvate
Purity
97%
Packaging
5g
Price
$26
Updated
2024/03/01
TCI Chemical
Product number
T1434
Product name
Ethyl Trifluoropyruvate
Purity
>98.0%(GC)
Packaging
5g
Price
$47
Updated
2024/03/01
TCI Chemical
Product number
T1434
Product name
Ethyl Trifluoropyruvate
Purity
>98.0%(GC)
Packaging
25g
Price
$135
Updated
2024/03/01
Alfa Aesar
Product number
B20611
Product name
Ethyl trifluoropyruvate, 97%
Packaging
5g
Price
$46.65
Updated
2024/03/01
Alfa Aesar
Product number
B20611
Product name
Ethyl trifluoropyruvate, 97%
Packaging
25g
Price
$184
Updated
2024/03/01
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Ethyl trifluoropyruvate Chemical Properties,Usage,Production

Chemical Properties

Clear pale yellow liquid

Uses

Ethyl trifluoropyruvate acts as a building block in synthetic chemistry for the synthesis of fluorine containing compounds. It is also used as a reagent for the preparation of potential biologically active compounds like highly enantioselective organocatalytic hydroxyalkylation of indoles.

Uses

Ethyl 3,3,3-trifluoropyruvate may be used in the preparation of N-heteroaryl(trifluoromethyl)hydroxyalkanoic acid esters.

Uses

Ethyl Trifluoropyruvate is used as a reagent in the preparation of potential biologically active compounds such as in the highly enantioselective organocatalytic hydroxyalkylation of indoles .

General Description

Ethyl 3,3,3-trifluoropyruvate is a trifluoromethylated compound. Enantioselective Friedel–Crafts alkylation of simple phenols and indoles with ethyl 3,3,3-trifluoropyruvate under different reaction conditions have been reported.

Synthesis

To 58 mL (1.0 mL/mmol) of acetonitrile, 10 g (58 mmol, 1.0 eq) of ethyl 3,3,3-trifluorolactate was added and dissolved therein.Furthermore, 11 g (67 mmol, 1.2 eq) of NaClO.5H2O was added, followed by stirring at 20° C. for 30 minutes.As the reaction-terminated liquid was analyzed by 19F-NMR, conversion was 100%, and selectivity was 98%.To the reaction-terminated liquid, 0.38 g (1.5 mmol, 0.026 eq) of sodium thiosulfate pentahydrate was added, followed by stirring, thereby quenching the remaining oxidation agent.Furthermore, 0.33 g (3.9 mmol, 0.067 eq) of sodium hydrogencarbonate and 10 g (70 mmol, 1.2 eq) of sodium sulfate were added, followed by stirring and then removing solid matter by filtration.As the filtrate was quantified with internal standard method (internal standard substance: α,α,α-trifluorotoluene) by 19F-NMR, Ethyl trifluoropyruvate was contained by 56 mmol (quantitative yield: 97%).By a simple distillation (up to 48° C./0.5 kPa) of the filtrate, 7.6 g of Ethyl trifluoropyruvate was obtained. 19F-NMR purity was 99% (40 mmol), and the total yield was 69%.

Ethyl trifluoropyruvate Preparation Products And Raw materials

Raw materials

Preparation Products

6-CHLORO-2-(TRIFLUOROMETHYL)QUINOLINE-4-CARBOXYLIC ACID 2-(TRIFLUOROMETHYL)-5,7-DIMETHYLQUINOLINE-4-CARBOXYLIC ACID 5-CHLORO-2-(TRIFLUOROMETHYL)QUINOLINE-4-CARBOXYLIC ACID 2-(TRIFLUOROMETHYL)-5-METHYLQUINOLINE-4-CARBOXYLIC ACID
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Ethyl trifluoropyruvate Suppliers

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View Lastest Price from Ethyl trifluoropyruvate manufacturers

Hebei Chuanghai Biotechnology Co,.LTD
Product
Ethyl trifluoropyruvate 13081-18-0
Price
US $9.00/KG
Min. Order
1KG
Purity
99.9
Supply Ability
1 ton
Release date
2024-08-19
Henan Aochuang Chemical Co.,Ltd.
Product
Ethyl trifluoropyruvate 13081-18-0
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
1ton
Release date
2022-09-16
Longyan Tianhua Biological Technology Co., Ltd
Product
Ethyl trifluoropyruvate 13081-18-0
Price
US $50.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
10000KG
Release date
2020-10-29

13081-18-0, Ethyl trifluoropyruvateRelated Search:

Ethyl 4,4,4-trifluoroacetoacetate Ethyl acetoacetate Phosphoenolpyruvate carboxylase Ethylparaben Ethyl bromopyruvate Calcium pyruvate Trinexapac-ethyl ISOXADIFEN-ETHYL PYRUVATE DEHYDROGENASE EC 2.7.1.40 Dimethyl succinate Methyl acrylate Ethanol Ethyl acetate Ethyl bromodifluoroacetate Ethyl propionate Ethyl trifluoroacetate Ethyl 2,4-dioxovalerate

  • Ethyl trifluoropyruvate, Ethyl 2-oxo-3,3,3-trifluoropropionate
  • Threefluorideethylpyruvate
  • Ethyl 3,3,3-trifluoropyruvate 97%
  • ETHYL TRIFLUOROPYRUVATE
  • ETHYL 3,3,3-TRIFLUOROPYRUVATE
  • ETHYL 3,3,3-TRIFLUORO-2-OXOPROPANOATE
  • ETHYL 2-OXO-3,3,3-TRIFLUORO PROPIONATE
  • E-TFPA
  • 3,3,3-TRIFLUORO-2-OXOPROPANOIC ACID ETHYL ESTER
  • RARECHEM AL BI 1300
  • TRIFLUOROPYRUVIC ACID ETHYL ESTER
  • Ethyl trifluoropyruvate 98%
  • Ethyltrifluoropyruvate98%
  • 3,3,3-Trifluoropyruvic acid ethyl ester
  • Ethyl 2-oxo-3,3,3-trifluoropropanoate
  • Ethyl 2-oxo-3,3,3-trifluoropropanoate 97%
  • ETHYL 3,3,3-TRIFLUORO-2-O
  • Ethyl 3,3,3-trifluoropyruvate,98+%
  • Ethyl-trifluoroMethylpyruvate
  • Propanoic acid, 3,3,3-trifluoro-2-oxo-, ethyl ester
  • 3,3, 3-trifluoropyruvate, ethyl ester
  • TIANFUCHEM--13081-18-0--Ethyl trifluoropyruvate factory price
  • 13081-18-0
  • 3081-18-0
  • 1308-18-0
  • C5H5F3O3
  • CF3COCO2C2H5
  • Esters
  • Organic Building Blocks
  • Carbonyl Compounds
  • C2 to C5
  • Building Blocks
  • C2 to C5
  • Carbonyl Compounds
  • Esters