ChemicalBook > CAS DataBase List > Z-ASP-2,6-DICHLOROBENZOYLOXYMETHYLKETONE

Z-ASP-2,6-DICHLOROBENZOYLOXYMETHYLKETONE

Product Name
Z-ASP-2,6-DICHLOROBENZOYLOXYMETHYLKETONE
CAS No.
153088-73-4
Chemical Name
Z-ASP-2,6-DICHLOROBENZOYLOXYMETHYLKETONE
Synonyms
FHN88734;Z-D-CH2-DCB;Z-ASP-CH2-DCB;ICE INHIBITOR V;ICE INHIBITOR VI;CASPASE-1 INHIBITOR V;CASPASE-1 INHIBITOR III;Z-ASP-[(2,6-DICHLOROBENZOYL)OXY]METHANE;ZAspCH2DCB,Z Asp CH2 DCB,Z-Asp-CH-2-DCB;Z-ASP-2,6-DICHLOROBENZOYLOXYMETHYLKETONE
CBNumber
CB8336473
Molecular Formula
C20H17Cl2NO7
Formula Weight
454.26
MOL File
153088-73-4.mol
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Z-ASP-2,6-DICHLOROBENZOYLOXYMETHYLKETONE Property

Boiling point:
674.2±55.0 °C(Predicted)
Density 
1.440±0.06 g/cm3(Predicted)
storage temp. 
−20°C
solubility 
Soluble in DMSO (up to 25 mg/ml).
form 
White to off-white powder.
pka
4.01±0.19(Predicted)
color 
white
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
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Safety

WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical
Product number
15143
Product name
Z-Asp-CH2-DCB
Purity
≥98%
Packaging
5mg
Price
$66
Updated
2024/03/01
Cayman Chemical
Product number
15143
Product name
Z-Asp-CH2-DCB
Purity
≥98%
Packaging
10mg
Price
$98
Updated
2024/03/01
Cayman Chemical
Product number
15143
Product name
Z-Asp-CH2-DCB
Purity
≥98%
Packaging
25mg
Price
$228
Updated
2024/03/01
Cayman Chemical
Product number
15143
Product name
Z-Asp-CH2-DCB
Purity
≥98%
Packaging
50mg
Price
$421
Updated
2024/03/01
TRC
Product number
A790193
Product name
Z-Asp-2,6-Dichlorobenzoyloxymethylketone
Packaging
25mg
Price
$165
Updated
2021/12/16
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Z-ASP-2,6-DICHLOROBENZOYLOXYMETHYLKETONE Chemical Properties,Usage,Production

Description

Z-Asp-CH2-DCB is a peptide originally synthesized for its ability to inactivate the interleukin-1β-converting enzyme, which is the homolog of the C. elegans positive regulator of apoptosis CED-3. Z-Asp-CH2-DCB has been shown to block apoptosis by nonselectively inhibiting caspase activity. At 1-100 μM, it can dose-dependently block the production of IL-1β, TNF-α, IL-6, and IFN-γ by human peripheral blood mononuclear cells as well as inhibit T cell proliferation.

Uses

Z-Asp-2,6-dichlorobenzoyloxymethylketone is a broad Caspase Inhibitor.

References

1) Dolle et al. (1994) P1 aspartate-based peptide alpha-((2,6-dichlorobenzoyl)oxy)methyl ketones as potent time-dependent inhibitors of interleukin-1 beta-converting enzyme; J.Med.Chem. 37 563

Z-ASP-2,6-DICHLOROBENZOYLOXYMETHYLKETONE Preparation Products And Raw materials

Raw materials

Preparation Products

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Z-ASP-2,6-DICHLOROBENZOYLOXYMETHYLKETONE Suppliers

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153088-73-4, Z-ASP-2,6-DICHLOROBENZOYLOXYMETHYLKETONERelated Search:

AC-VDVAD-PNA Z-VAD-FMK Z-ARG-PNA HCL CASPASE INHIBITOR3 AC-VEID-AMC Z-YVAD-AFC ALPHA-(TRICHLOROMETHYL)-4-PYRIDINEETHANOL AC-VDVAD-CHO AC-DEVD-AFC PAC1 AC-DEVD-CHO Z-ALA-PRO-PNA Z-ALA-SER-OH Z-ALA-GLY-OH Z-ASP-GLN-MET-ASP-AFC AC-LEHD-AFC AC-LEU-GLU-THR-ASP-AFC ETHYL 2,6-DICHLOROBENZOATE

  • ICE INHIBITOR V
  • ICE INHIBITOR VI
  • CASPASE-1 INHIBITOR V
  • CASPASE-1 INHIBITOR III
  • (BENZYLOXYCARBONYL-L-ASPART-1-YL)[(2,6-DICHLOROBENZOYL)OXY]METHANE
  • Z-ASP-[(2,6-DICHLOROBENZOYL)OXY]METHANE
  • Z-ASP-2,6-DICHLOROBENZOYLOXYMETHYLKETONE
  • Z-D-CH2-DCB
  • Z-ASP-CH2-DCB
  • Z-L-ASP-ALPHA-[(2,6-DICHLOROBENZOYL)OXY]METHANE
  • N-cbz-L-aspartic acid A-(2,6-dichloro-*benzoyloxy
  • N-CBZ-L-ASPARTIC ACID A-(2 6-DICHLORO- &
  • INTERLEUKIN-1BETA CONVERTING ENZYME INHIBITOR III
  • N-CBZ-L-aspartic acid alpha-[(2,6-dichlorobenzoyloxy)....
  • Z-L-Asp α-([2,6-dichlorobenzoyloxy]methyl ketone)
  • CASPASE-1 INHIBITOR V ;Z-VAL-ALA-ASP(OME)-FLUOROMETHYLKETONE
  • Benzoic acid, 2,6-dichloro-, (3S)-4-carboxy-2-oxo-3-[[(phenylmethoxy)carbonyl]amino]butyl ester
  • ZAspCH2DCB,Z Asp CH2 DCB,Z-Asp-CH-2-DCB
  • FHN88734
  • 153088-73-4
  • C20H17Cl2NO7
  • Pepetides
  • peptides
  • Caspase/Related Products