EC 2.4.2.4
- Product Name
- EC 2.4.2.4
- CAS No.
- 9030-23-3
- Chemical Name
- EC 2.4.2.4
- Synonyms
- TYMP;MNGIE;ECGF1;Gliostatin;EC 2.4.2.4;THYMIDINE PHOSPHORYLASE;Phosphorylase,thymidine;Thymidine Phosphorylase, recombinant;THYMIDINE PHOSPHORYLASE FROM*ESCHERICHIA COLI;ANTI-ECGF1 (CENTER) antibody produced in rabbit
- CBNumber
- CB8341855
- Formula Weight
- 0
- MOL File
- Mol file
EC 2.4.2.4 Property
- storage temp.
- 2-8°C
- form
- buffered aqueous solution
Safety
- WGK Germany
- -
N-Bromosuccinimide Price
- Product number
- T2807
- Product name
- Thymidine Phosphorylase, recombinant from Escherichia coli
- Purity
- recombinant, expressed in E. coli, buffered aqueous solution, ≥500?units/mL
- Packaging
- 500units
- Price
- $156
- Updated
- 2024/03/01
- Product number
- T2807
- Product name
- Thymidine Phosphorylase, recombinant from Escherichia coli
- Purity
- recombinant, expressed in E. coli, buffered aqueous solution, ≥500?units/mL
- Packaging
- 1000units
- Price
- $201
- Updated
- 2024/03/01
- Product number
- T6632
- Product name
- Thymidine Phosphorylase, recombinant from Escherichia coli
- Purity
- recombinant, expressed in E. coli, buffered aqueous solution, ≥900?units/mL, aseptically filled
- Packaging
- 5000units
- Price
- $1600
- Updated
- 2024/03/01
- Product number
- T2807
- Product name
- Thymidine Phosphorylase, recombinant from Escherichia coli
- Purity
- recombinant, expressed in E. coli, buffered aqueous solution, ≥500?units/mL
- Packaging
- 5000units
- Price
- $411.6
- Updated
- 2024/03/01
- Product number
- SRE0006
- Product name
- Thymidine Phosphorylase, recombinant from Escherichia coli
- Purity
- recombinant, expressed in E. coli, Suitable for manufacturing of diagnostic kits and reagents, buffered aqueous solution, ≥500?units/mL
- Packaging
- 5000units
- Price
- $300
- Updated
- 2024/03/01
EC 2.4.2.4 Chemical Properties,Usage,Production
Uses
Thymidine phosphorylase has been used in a study to evaluate biomarkers for advanced breast cancer patients treated with capecitabine-based first-line chemotherapy. Thymidine phosphorylase has also been used in a study to investigate implications for the clinical efficacy of nucleoside analogues.
Uses
Thymidine phosphorylase has been used in a study to assess TAS-102 treatment in patients with advanced solid tumors. Thymidine phosphorylase has also been used in a study to investigate antitumor effects of the FP3 protein on patient-derived tumor tissue xenograft models of primary colon carcinoma.
General Description
Thymidine phosphorylase inhibits vascular smooth muscle cell proliferation.
Biochem/physiol Actions
An enzyme that catalyzes the reversible conversion of thymidine to thymine. Thymidine phosphorylase is part of the pyrimidine nucleoside salvage pathway. This pathway allows pyrimidine bases to be recycled for nucleotide biosynthesis, while the pentose 1-phosphates are converted to intermediates of the pentose phosphate shunt and glycolysis. The E. coli thymidine phosphorylase shares 40% sequence homology with the human sequence, which has been found to be identical to the angiogenic agent platelet-derived endothelial growth factor. The purified E. coli enzyme has been shown to stimulate blood vessel growth in chick chorioallantoic membrane assays.