Description Uses
ChemicalBook > CAS DataBase List > Cyclopropanecarboxylic acid

Cyclopropanecarboxylic acid

Description Uses
Product Name
Cyclopropanecarboxylic acid
CAS No.
1759-53-1
Chemical Name
Cyclopropanecarboxylic acid
Synonyms
Cyclopropionic acid;cyclopropanecarboxylic;CYCLOPROPYL CARBOXYLIC ACID;CPC-ACID;Cyclopropane c;Cyclopropanic acid;Carboxycyclopropane;RARECHEM AL BO 0005;Ring propyl forMate;Olapali impurity 20
CBNumber
CB8343293
Molecular Formula
C4H6O2
Formula Weight
86.09
MOL File
1759-53-1.mol
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Cyclopropanecarboxylic acid Property

Melting point:
14-17 °C (lit.)
Boiling point:
182-184 °C (lit.)
Density 
1.081 g/mL at 25 °C (lit.)
refractive index 
n20/D 1.438(lit.)
Flash point:
161 °F
storage temp. 
2-8°C
solubility 
soluble in Chloroform, Ethyl Acetate
form 
Liquid
pka
4.83(at 25℃)
color 
Clear colorless to light yellow
PH
3 (10g/l, H2O, 22℃)
BRN 
969839
InChIKey
YMGUBTXCNDTFJI-UHFFFAOYSA-N
LogP
0.630
CAS DataBase Reference
1759-53-1(CAS DataBase Reference)
NIST Chemistry Reference
Cyclopropanecarboxylic acid(1759-53-1)
EPA Substance Registry System
Cyclopropanecarboxylic acid (1759-53-1)
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Safety

Hazard Codes 
C,Xi
Risk Statements 
34-22
Safety Statements 
26-36/37/39-45-27
RIDADR 
UN 3265 8/PG 2
WGK Germany 
3
RTECS 
GZ1100000
Hazard Note 
Irritant/Corrosive
TSCA 
Yes
HazardClass 
8
PackingGroup 
II
HS Code 
29162000
Toxicity
mouse,LD50,intraperitoneal,172mg/kg (172mg/kg),Journal of Pharmacy and Pharmacology. Vol. 21, Pg. 85, 1969.
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H314Causes severe skin burns and eye damage

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P363Wash contaminated clothing before reuse.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
C116602
Product name
Cyclopropanecarboxylic acid
Purity
95%
Packaging
25g
Price
$47.2
Updated
2024/03/01
Sigma-Aldrich
Product number
C116602
Product name
Cyclopropanecarboxylic acid
Purity
95%
Packaging
100g
Price
$65.2
Updated
2024/03/01
TCI Chemical
Product number
C0387
Product name
Cyclopropanecarboxylic Acid
Purity
>98.0%(GC)(T)
Packaging
25mL
Price
$25
Updated
2024/03/01
TCI Chemical
Product number
C0387
Product name
Cyclopropanecarboxylic Acid
Purity
>98.0%(GC)(T)
Packaging
100mL
Price
$67
Updated
2024/03/01
Alfa Aesar
Product number
A14215
Product name
Cyclopropanecarboxylic acid, 98%
Packaging
50g
Price
$46.65
Updated
2024/03/01
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Cyclopropanecarboxylic acid Chemical Properties,Usage,Production

Description

Cyclopropanecarboxylic acid is a kind of organic acid. It is a clear liquid used as an intermediate for agrochemicals, pharmaceuticals, and other organic synthesis for the applications of electronics, chemicals, polymer additives, coatings, adhesives, surfactants, and other applications1. Moreover, its derivatives of are used against parasites in plants and animals. For example, the alkynyl esters of cyclopropane-carboxylic acid are used as pesticides. Similarly, cyclopropane carboxylic acid esters containing a polyhalogenated substituent are used as fungicides. The ethyl derivative is reagent used in the addition of cyclopropane and can act as annulation reagent for the conversion of aromatics to 2-methylindanones under Friedel-Crafts conditions2.

Uses

Cyclopropanecarboxylic acid is a monocarboxylic acid and a member of cyclopropanes. It is a conjugate acid of a cyclopropanecarboxylate.

Chemical Properties

clear colourless to light yellow liquid

Uses

Cyclopropanecarboxylic Acid is used as a reagent in the synthesis of substituted 4-(thiophen-2-ylmethyl)-2H-phthalazin-1-ones as potent PARP-1 inhibitors. Also used as a reagent in the synthesis of 2-alkyloxazoles as potent and selective PI4KIIIb inhibitors demonstrating inhibition of HCV replication.

Definition

ChEBI: Cyclopropanecarboxylic acid is a monocarboxylic acid and a member of cyclopropanes. It is a conjugate acid of a cyclopropanecarboxylate.

Preparation

Cyclopropanecarboxylic acid has been prepared by the hydrolysis of cyclopropyl cyanide, although it is unnecessary to isolate the nitrile; by heating cyclopropanedicarboxylic acid; and by the action of alkali on ethyl γ-chlorobutyrate.7 The last two methods do not appear to be of practical importance. The oxidation of cyclopropyl methyl ketone with sodium hypobromite is reported to be an excellent preparative method for this acid.
Org. Synth. 1944, 24, 36
DOI: 10.15227/orgsyn.024.0036

Cyclopropanecarboxylic acid Preparation Products And Raw materials

Raw materials

Methyl 4-chlorobutyrate Zinc chloride 4-Chlorobutyryl chloride 4-Chlorobutyronitrile Butyl butyrate Gamma Butyrolactone

Preparation Products

3-(1，2，2，2-tetrabromoethyl)-2，2-dimethyl cyclo-propane carboxylic acid CYCLOPROTHRIN Cilastatin Cyclopropanecarbonyl Chloride (1R-cis)-3-(2,2-dibromoethenyl)-2,2-dimethylcyclopropane carboxylic acid Deltamethrin (1-Aminocyclopropyl)methanol Ethyl 2,2,3,3-tetramethylcyclopropane-carboxylate (Bromomethyl)cyclopropane Permethrin 5-CYCLOPROPYL-2H-PYRAZOL-3-YLAMINE
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View Lastest Price from Cyclopropanecarboxylic acid manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD
Product
Cyclopropanecarboxylic acid 1759-53-1
Price
US $0.00/KG
Min. Order
1KG
Purity
97%
Supply Ability
500kgs/month
Release date
2021-10-28
Hebei Zhuanglai Chemical Trading Co.,Ltd
Product
Cyclopropanecarboxylic Acid 1759-53-1
Price
US $120.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
20ton
Release date
2024-05-30
Hebei Yanxi Chemical Co., Ltd.
Product
Cyclopropanecarboxylic acid 1759-53-1
Price
US $0.00/kg
Min. Order
1kg
Purity
99.00%
Supply Ability
20tons
Release date
2023-09-12

1759-53-1, Cyclopropanecarboxylic acidRelated Search:

Cyclopropyl carbinol Ciprofloxacin hydrochloride Cyclopropyl methyl ketone tert-butyl cyclopropanecarboxylate Propiconazole Methyl cyclopropane carboxylate Cyclopropyl methoxylamine Cyclopentanecarboxylic acid Stearic acid Cyclopropane-1-carboximidamide hydrochloride Folic acid Ciprofloxacin Aminomethylcyclopropane Citric acid Cyclobutanecarboxylic acid Ethyl 2-(Chlorosulfonyl)acetate CYCLOPROPANECARBOXYLIC ACID HYDRAZIDE Ascoric Acid

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