4-Hydroxy-D-(-)-2-phenylglycine

Product Name: 4-Hydroxy-D-(-)-2-phenylglycine
CAS No.: 22818-40-2
Chemical Name: 4-Hydroxy-D-(-)-2-phenylglycine
Synonyms: (R)-2-AMino-2-(4-hydroxyphenyl)acetic acid;H-D-PHG(4-OH)-OH;D-4-HYDROXYPHENYLGLYCINE;4-HYDROXY-D-PHENYLGLYCINE;(R)-(-)-2-Phenylglycine amide;AMoxicillin Related CoMpound I;(2R)-2-amino-2-(4-hydroxyphenyl)acetic acid;B8372699;H-D-HPG-OH;D-4-OH-Phg-OH
CBNumber: CB8372699
Molecular Formula: C8H9NO3
Formula Weight: 167.16
MOL File: 22818-40-2.mol

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4-Hydroxy-D-(-)-2-phenylglycine Property

Melting point:: 240 °C (dec.)(lit.)
alpha: -156 º (c=1, 1 N HCl)
Boiling point:: 295.73°C (rough estimate)
Density: 1.396
vapor pressure: 0Pa at 25℃
refractive index: -158 ° (C=1, 1mol/L HCl)
storage temp.: 2-8°C
solubility: 5g/l
form: Liquid
pka: 2.15±0.10(Predicted)
color: Clear colorless to yellow
optical activity: [α]23/D 158±3°, c = 1 in 1 M HCl
Water Solubility: 5 g/L (20 ºC)
BRN: 2210998
LogP: -2.25
CAS DataBase Reference: 22818-40-2(CAS DataBase Reference)
EPA Substance Registry System: Benzeneacetic acid, .alpha.-amino-4-hydroxy-, (.alpha.R)- (22818-40-2)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36-24/25
WGK Germany: 3
TSCA: Yes
HS Code: 29225000

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: PHR2196
Product name: Amoxicillin Related Compound I
Packaging: 50MG
Price: $485
Updated: 2024/03/01

Sigma-Aldrich

Product number: 215333
Product name: 4-Hydroxy-D-phenylglycine
Purity: ≥98%
Packaging: 25g
Price: $50.1
Updated: 2023/06/20

Sigma-Aldrich

Product number: 1031591
Product name: Amoxicillin Related Compound I
Purity: United States Pharmacopeia (USP) Reference Standard
Packaging: 25mg
Price: $1310
Updated: 2022/05/15

TCI Chemical

Product number: H0758
Product name: 4-Hydroxy-D-(-)-2-phenylglycine
Purity: >99.0%(HPLC)(T)
Packaging: 25g
Price: $40
Updated: 2024/03/01

TCI Chemical

Product number: H0758
Product name: 4-Hydroxy-D-(-)-2-phenylglycine
Purity: >99.0%(HPLC)(T)
Packaging: 100g
Price: $77
Updated: 2024/03/01

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4-Hydroxy-D-(-)-2-phenylglycine Chemical Properties,Usage,Production

Description

d-(p-Hydroxyphenyl)glycine (d-HPG) is widely used in large amounts as an important intermediate for the synthesis of amoxicillin and several other semisynthetic β-lactam antibiotics.

Chemical Properties

off-white powder

Uses

4-Hydroxy-D-(-)-2-phenylglycine (Cefadroxil EP Impurity A(Amoxicillin EP Impurity A)) is an compound used mainly for the synthetic preparation of β-lactam antibiotics.

Uses

4-Hydroxy-D-(-)-2-phenylglycine is an compound used mainly for the synthetic preparation of β-lactam antibiotics.

Definition

ChEBI: The D-enantiomer of 4-hydroxyphenylglycine. A non-proteinogenic amino acid found in Herpetosiphon aurantiacus.

Flammability and Explosibility

Non flammable

reaction suitability

reaction type: solution phase peptide synthesis

Purification Methods

Crystallise it from water and dry it in vacuo. [Beilstein 14 I 659.]

4-Hydroxy-D-(-)-2-phenylglycine Preparation Products And Raw materials

Raw materials

DL-P-Hydroxyphenylglycine Glyoxal Phenol DL-Tartaric acid D(-)-Tartaric acid p-Anisaldehyde Glyoxylic acid

Preparation Products

D-(-)-A-4-HYDROXYPHENYLGLYCINE DANE SALT METHYL POTASSIUM (2R)-2-[(4-Ethyl-2,3-dioxopiperazinyl)carbonylamino]-2-(4-hydroxyphenyl)acetic acid

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4-Hydroxy-D-(-)-2-phenylglycine Suppliers

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View Lastest Price from 4-Hydroxy-D-(-)-2-phenylglycine manufacturers

Hebei Mujin Biotechnology Co.,Ltd

Product: 4-Hydroxy-D-(-)-2-phenylglycine 22818-40-2
Price: US $0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 50000KG/month
Release date: 2023-06-28

Apeloa production Co.,Limited

Product: D(-)-4-Hydroxyphenylglycine 22818-40-2
Price: US $1.00/g
Min. Order: 1g
Purity: 98%
Supply Ability: 1000
Release date: 2024-06-05

ShenZhen H&D Pharmaceutical Technology Co., LTD

Product: Amoxicillin Impurity I 22818-40-2
Price: US $0.00-0.00/mg
Min. Order: 10mg
Purity: 98%
Supply Ability: 500mg
Release date: 2024-05-28

22818-40-2, 4-Hydroxy-D-(-)-2-phenylglycineRelated Search:

4-Hydroxybenzoic acid 4-Aminophenylacetic acid 6-Aminocaproic acid D-2-Phenylglycine Glycine CHLOROPHOSPHONAZO III Methylparaben Betaine 4-Hydroxyphenylacetic acid Anilinoacetic acid α-Lipoic Acid D-(-)-A-4-HYDROXYPHENYLGLYCINE DANE SALT METHYL POTASSIUM,D-(-)-ALPHA-4-HYDROXYPHENYLGLYCINE DANE SALT METHYL POTASSIUM L-Phenylglycine 4-Hydroxybenzaldehyde D-4-Hydroxyphenylglycine methyl ester D(+)-Trehalose dihydrate D(+)-Malic acid (S)-Amlodipine

4-HYDROXY-D-PHENYLGLYCINE

(R)-(-)-AMINO(4-HYDROXYPHENYL)ACETIC ACID

(R)-AMINO-(4-HYDROXY-PHENYL)-ACETIC ACID

(r)-alpha-amino-4-hydroxybenzeneacetic acid

(R)-ALPHA-AMINO-4-HYDROXYPHENYLACETIC ACID

(R)-4-HYDROXYPHENYLGLYCINE

(R)-(-)-2-(4-HYDROXYPHENYL)GLYCINE

D-(-)-2-(4-HYDROXYPHENYL)GLYCINE

D(-)-2-(P-HYDROXYPHENYL)GLYCINE

D-(-)-A-4-HYDROXYPHENYLGLYCINE

D-4-HYDROXYPHENYLGLICYNE

D-(-)-4-HYDROXYPHENYLGLYCINE

D-4-HYDROXYPHENYLGLYCINE

D-ALPHA-PARA-HYDROXYPHENYLGLYCINE

(D)-(-)-ALFA-4-HYDROXYPHENYL GLYCINE

D-(-)-P-HYDROXYPHENYLGLYCINE

D-P-HYDROXYPHENYLGLYCINE

D(-)PARA-HYDROXY-PHENYLGLYCINE

HYDROXY PHENYL GLYCINE

H-D-HPG-OH

H-D-PHG(4-OH)-OH

H-D-PHG(4-HYDROXY)-OH

Cefoperazone Impurity 3

Amoxicillin Impurity 8（EP Impurity I）

Cefprozil Impurity 1（Cefprozil EP Impurity A）

Cefadroxil Impurity 7（Cefadroxil EP Impurity A）

D-(-)Pare Hydroxyphenylglycine

(theta)-benzeneaceticaci

.alpha.-amino-4-hydroxy-,(R)-Benzeneaceticacid

a-Amino-p-hydroxyphenylaceticacid

Benzeneaceticacid,alpha.-amino-4-hydroxy-,(R)-

Benzeneaceticacid,-amino-4-hydroxy-,(R)-

L-(-)-4-Hydroxy-α-aminophenylacetic acid

D(-)-P-Hydroxyphenylglycine, 98+%

(2R)-2-(4-Hydroxyphenyl)glycine

(R)-2-(p-Hydroxyphenyl)glycine

p-Hydroxy-D-phenylglycine

α-(4-Hydroxyphenyl)-D-glycine

(2R)-2-Amino-2-(4-hydroxyphenyl)ethanoic acid, (R)-Amino(4-hydroxyphenyl)acetic acid

Amoxicillin Related Compound I (15 mg) ((R)-2-Amino-2-(4-hydroxyphenyl)acetic acid)

D(-)-4-Hydroxyphenylglycine, 98+% 100GR

D(-)-4-Hydroxyphenylglycine, 98+% 25GR

D(-)-4-Hydroxyphenylglycine ,99%

D(-)-alpha-para-Hydroxyphenylglycine base

(R)-(-)-2-Amino-2-(4-hydroxyphenyl)acetic Acid 4-Hydroxy-D-phenylglycine

Benzeneacetic acid, a-aMino-4-hydroxy-, (aR)-

4-Hydroxy-D-(-)-2-phenylglycine

(R)-2-AMino-2-(4-hydroxyphenyl)acetic acid

AMoxicillin EP IMpurity I

(-)-4-Hydroxy-D-phenylglycine, 98+%

D-(-)p-hydroxyphenylgcine Dane salt

AMoxicillin Related CoMpound I

4-Hydroxy-D-(-)-2-phenylglycine, 99.0%(LC&T

D(-)-4-Hydroxyphenylglycine 4-Hydroxy-D-phenylglycine

Cefprozil impurity A

Cefadroxyl impurity A

Cefprozil Monohydrate EP Impurity A

(2R)-2-ammonio-2-(4-hydroxyphenyl)acetate