ChemicalBook > CAS DataBase List > 4-Hydroxy-D-(-)-2-phenylglycine

4-Hydroxy-D-(-)-2-phenylglycine

Product Name
4-Hydroxy-D-(-)-2-phenylglycine
CAS No.
22818-40-2
Chemical Name
4-Hydroxy-D-(-)-2-phenylglycine
Synonyms
(R)-2-AMino-2-(4-hydroxyphenyl)acetic acid;H-D-PHG(4-OH)-OH;D-4-HYDROXYPHENYLGLYCINE;4-HYDROXY-D-PHENYLGLYCINE;(R)-(-)-2-Phenylglycine amide;AMoxicillin Related CoMpound I;(2R)-2-amino-2-(4-hydroxyphenyl)acetic acid;B8372699;H-D-HPG-OH;D-4-OH-Phg-OH
CBNumber
CB8372699
Molecular Formula
C8H9NO3
Formula Weight
167.16
MOL File
22818-40-2.mol
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4-Hydroxy-D-(-)-2-phenylglycine Property

Melting point:
240 °C (dec.)(lit.)
alpha 
-156 º (c=1, 1 N HCl)
Boiling point:
295.73°C (rough estimate)
Density 
1.396
vapor pressure 
0Pa at 25℃
refractive index 
-158 ° (C=1, 1mol/L HCl)
storage temp. 
2-8°C
solubility 
5g/l
form 
Liquid
pka
2.15±0.10(Predicted)
color 
Clear colorless to yellow
optical activity
[α]23/D 158±3°, c = 1 in 1 M HCl
Water Solubility 
5 g/L (20 ºC)
BRN 
2210998
LogP
-2.25
CAS DataBase Reference
22818-40-2(CAS DataBase Reference)
EPA Substance Registry System
Benzeneacetic acid, .alpha.-amino-4-hydroxy-, (.alpha.R)- (22818-40-2)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36-24/25
WGK Germany 
3
TSCA 
Yes
HS Code 
29225000
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
PHR2196
Product name
Amoxicillin Related Compound I
Packaging
50MG
Price
$485
Updated
2024/03/01
Sigma-Aldrich
Product number
215333
Product name
4-Hydroxy-D-phenylglycine
Purity
≥98%
Packaging
25g
Price
$50.1
Updated
2023/06/20
Sigma-Aldrich
Product number
1031591
Product name
Amoxicillin Related Compound I
Purity
United States Pharmacopeia (USP) Reference Standard
Packaging
25mg
Price
$1310
Updated
2022/05/15
TCI Chemical
Product number
H0758
Product name
4-Hydroxy-D-(-)-2-phenylglycine
Purity
>99.0%(HPLC)(T)
Packaging
25g
Price
$40
Updated
2024/03/01
TCI Chemical
Product number
H0758
Product name
4-Hydroxy-D-(-)-2-phenylglycine
Purity
>99.0%(HPLC)(T)
Packaging
100g
Price
$77
Updated
2024/03/01
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4-Hydroxy-D-(-)-2-phenylglycine Chemical Properties,Usage,Production

Description

d-(p-Hydroxyphenyl)glycine (d-HPG) is widely used in large amounts as an important intermediate for the synthesis of amoxicillin and several other semisynthetic β-lactam antibiotics.

Chemical Properties

off-white powder

Uses

4-Hydroxy-D-(-)-2-phenylglycine (Cefadroxil EP Impurity A(Amoxicillin EP Impurity A)) is an compound used mainly for the synthetic preparation of β-lactam antibiotics.

Uses

4-Hydroxy-D-(-)-2-phenylglycine is an compound used mainly for the synthetic preparation of β-lactam antibiotics.

Definition

ChEBI: The D-enantiomer of 4-hydroxyphenylglycine. A non-proteinogenic amino acid found in Herpetosiphon aurantiacus.

Flammability and Explosibility

Non flammable

reaction suitability

reaction type: solution phase peptide synthesis

Purification Methods

Crystallise it from water and dry it in vacuo. [Beilstein 14 I 659.]

4-Hydroxy-D-(-)-2-phenylglycine Preparation Products And Raw materials

Raw materials

DL-P-Hydroxyphenylglycine Glyoxal Phenol DL-Tartaric acid D(-)-Tartaric acid p-Anisaldehyde Glyoxylic acid

Preparation Products

D-(-)-A-4-HYDROXYPHENYLGLYCINE DANE SALT METHYL POTASSIUM (2R)-2-[(4-Ethyl-2,3-dioxopiperazinyl)carbonylamino]-2-(4-hydroxyphenyl)acetic acid
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View Lastest Price from 4-Hydroxy-D-(-)-2-phenylglycine manufacturers

Hebei Mujin Biotechnology Co.,Ltd
Product
4-Hydroxy-D-(-)-2-phenylglycine 22818-40-2
Price
US $0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
50000KG/month
Release date
2023-06-28
Apeloa production Co.,Limited
Product
D(-)-4-Hydroxyphenylglycine 22818-40-2
Price
US $1.00/g
Min. Order
1g
Purity
98%
Supply Ability
1000
Release date
2024-06-05
ShenZhen H&D Pharmaceutical Technology Co., LTD
Product
Amoxicillin Impurity I 22818-40-2
Price
US $0.00-0.00/mg
Min. Order
10mg
Purity
98%
Supply Ability
500mg
Release date
2024-05-28

22818-40-2, 4-Hydroxy-D-(-)-2-phenylglycineRelated Search:

4-Hydroxybenzoic acid 4-Aminophenylacetic acid 6-Aminocaproic acid D-2-Phenylglycine Glycine CHLOROPHOSPHONAZO III Methylparaben Betaine 4-Hydroxyphenylacetic acid Anilinoacetic acid α-Lipoic Acid D-(-)-A-4-HYDROXYPHENYLGLYCINE DANE SALT METHYL POTASSIUM,D-(-)-ALPHA-4-HYDROXYPHENYLGLYCINE DANE SALT METHYL POTASSIUM L-Phenylglycine 4-Hydroxybenzaldehyde D-4-Hydroxyphenylglycine methyl ester D(+)-Trehalose dihydrate D(+)-Malic acid (S)-Amlodipine

  • 4-HYDROXY-D-PHENYLGLYCINE
  • (R)-(-)-AMINO(4-HYDROXYPHENYL)ACETIC ACID
  • (R)-AMINO-(4-HYDROXY-PHENYL)-ACETIC ACID
  • (r)-alpha-amino-4-hydroxybenzeneacetic acid
  • (R)-ALPHA-AMINO-4-HYDROXYPHENYLACETIC ACID
  • (R)-4-HYDROXYPHENYLGLYCINE
  • (R)-(-)-2-(4-HYDROXYPHENYL)GLYCINE
  • D-(-)-2-(4-HYDROXYPHENYL)GLYCINE
  • D(-)-2-(P-HYDROXYPHENYL)GLYCINE
  • D-(-)-A-4-HYDROXYPHENYLGLYCINE
  • D-4-HYDROXYPHENYLGLICYNE
  • D-(-)-4-HYDROXYPHENYLGLYCINE
  • D-4-HYDROXYPHENYLGLYCINE
  • D-ALPHA-PARA-HYDROXYPHENYLGLYCINE
  • (D)-(-)-ALFA-4-HYDROXYPHENYL GLYCINE
  • D-(-)-P-HYDROXYPHENYLGLYCINE
  • D-P-HYDROXYPHENYLGLYCINE
  • D(-)PARA-HYDROXY-PHENYLGLYCINE
  • HYDROXY PHENYL GLYCINE
  • H-D-HPG-OH
  • H-D-PHG(4-OH)-OH
  • H-D-PHG(4-HYDROXY)-OH
  • Cefoperazone Impurity 3
  • Amoxicillin Impurity 8（EP Impurity I）
  • Cefprozil Impurity 1（Cefprozil EP Impurity A）
  • Cefadroxil Impurity 7（Cefadroxil EP Impurity A）
  • D-(-)Pare Hydroxyphenylglycine
  • (theta)-benzeneaceticaci
  • .alpha.-amino-4-hydroxy-,(R)-Benzeneaceticacid
  • a-Amino-p-hydroxyphenylaceticacid
  • Benzeneaceticacid,alpha.-amino-4-hydroxy-,(R)-
  • Benzeneaceticacid,-amino-4-hydroxy-,(R)-
  • L-(-)-4-Hydroxy-α-aminophenylacetic acid
  • D(-)-P-Hydroxyphenylglycine, 98+%
  • (2R)-2-(4-Hydroxyphenyl)glycine
  • (R)-2-(p-Hydroxyphenyl)glycine
  • p-Hydroxy-D-phenylglycine
  • α-(4-Hydroxyphenyl)-D-glycine
  • (2R)-2-Amino-2-(4-hydroxyphenyl)ethanoic acid, (R)-Amino(4-hydroxyphenyl)acetic acid
  • Amoxicillin Related Compound I (15 mg) ((R)-2-Amino-2-(4-hydroxyphenyl)acetic acid)
  • D(-)-4-Hydroxyphenylglycine, 98+% 100GR
  • D(-)-4-Hydroxyphenylglycine, 98+% 25GR
  • D(-)-4-Hydroxyphenylglycine ,99%
  • D(-)-alpha-para-Hydroxyphenylglycine base
  • (R)-(-)-2-Amino-2-(4-hydroxyphenyl)acetic Acid 4-Hydroxy-D-phenylglycine
  • Benzeneacetic acid, a-aMino-4-hydroxy-, (aR)-
  • 4-Hydroxy-D-(-)-2-phenylglycine
  • (R)-2-AMino-2-(4-hydroxyphenyl)acetic acid
  • AMoxicillin EP IMpurity I
  • (-)-4-Hydroxy-D-phenylglycine, 98+%
  • D-(-)p-hydroxyphenylgcine Dane salt
  • AMoxicillin Related CoMpound I
  • 4-Hydroxy-D-(-)-2-phenylglycine, 99.0%(LC&T
  • D(-)-4-Hydroxyphenylglycine 4-Hydroxy-D-phenylglycine
  • Cefprozil impurity A
  • Cefadroxyl impurity A
  • Cefprozil Monohydrate EP Impurity A
  • (2R)-2-ammonio-2-(4-hydroxyphenyl)acetate