ChemicalBook > CAS DataBase List > 4-METHYLINDOLE-3-CARBOXALDEHYDE

4-METHYLINDOLE-3-CARBOXALDEHYDE

Product Name
4-METHYLINDOLE-3-CARBOXALDEHYDE
CAS No.
4771-48-6
Chemical Name
4-METHYLINDOLE-3-CARBOXALDEHYDE
Synonyms
4-METHYLINDOLE-3-ALDEHYDE;4-Methyl-3-carboxaldehyde;4-METHYLINDOLE-3-CARBALDEHYDE;4-Methylindole-3-caboxaldehyde;4-METHYLINDOLE-3-CARBOXALDEHYDE;4-Methyl-3-indolecarboxaldehyde;4-METHYL-1H-INDOLE-3-CARBALDEHYDE;4-Methyl-1H-indole-3-carboxaldehyde;1H-Indole-3-carboxaldehyde, 4-Methyl-;1H-Indole-3-carboxaldehyde, 4-methyl- (9CI)
CBNumber
CB8375524
Molecular Formula
C10H9NO
Formula Weight
159.18
MOL File
4771-48-6.mol
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4-METHYLINDOLE-3-CARBOXALDEHYDE Property

Melting point:
192-194℃
Boiling point:
347.0±22.0 °C(Predicted)
Density 
1.226
storage temp. 
under inert gas (nitrogen or Argon) at 2-8°C
form 
solid
pka
15.86±0.30(Predicted)
Appearance
Yellow to brown Solid
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Safety

Risk Statements 
36
Safety Statements 
26
HazardClass 
IRRITANT
HS Code 
2933998090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H319Causes serious eye irritation

Precautionary statements

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SYX00293
Product name
3-Formyl-4-methylindole
Packaging
1g
Price
$107
Updated
2025/07/31
TRC
Product number
F701230
Product name
3-Formyl-4-methylindole
Packaging
500mg
Price
$145
Updated
2021/12/16
Matrix Scientific
Product number
036846
Product name
4-Methyl-1H-indole-3-carbaldehyde
Packaging
1g
Price
$195
Updated
2021/12/16
Apolloscientific
Product number
OR960850
Product name
3-Formyl-4-methylindole
Purity
95%
Packaging
1g
Price
$125
Updated
2021/12/16
Matrix Scientific
Product number
036846
Product name
4-Methyl-1H-indole-3-carbaldehyde
Packaging
500mg
Price
$126
Updated
2021/12/16
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4-METHYLINDOLE-3-CARBOXALDEHYDE Chemical Properties,Usage,Production

Synthesis

16096-32-5

68-12-2

4771-48-6

GENERAL STEPS: The Vilsmeier-Haack reagent was prepared by slowly adding POCl3 (60 mmol, 6 mL) dropwise to dry DMF (30 mL) pre-cooled to 0 °C under stirring conditions. Subsequently, the reaction mixture was continued to be stirred at 0 °C for 10-15 min. 4-Methylindole (10 mmol) was dissolved in DMF (5 mL) and the resulting solution was added within the Vilsmeier-Haack reagent prepared above. The reaction mixture was warmed to 35 °C with continuous stirring for 1 hour. After completion of the reaction, it was cooled to room temperature and ice water (6 mL) and 30% NaOH aqueous solution (13 mL) were added sequentially, followed by heating the mixture to reflux for 20 min and then cooled to room temperature. The reaction mixture was extracted with dichloromethane (20 mL x 3), the organic phases were combined and dried with anhydrous Na2SO4. The solvent was removed by concentration under reduced pressure and the resulting crude product was purified by fast column chromatography using 15-25% acetone/petroleum ether (boiling range 60-90 °C) as eluent to afford the target product 4-methylindole-3-carbaldehyde.

References

[1] Chemical Biology and Drug Design, 2011, vol. 78, # 5, p. 864 - 868
[2] European Journal of Medicinal Chemistry, 2015, vol. 92, p. 776 - 783
[3] Bioorganic and Medicinal Chemistry Letters, 2003, vol. 13, # 7, p. 1301 - 1305
[4] Bioorganic and Medicinal Chemistry Letters, 2007, vol. 17, # 6, p. 1793 - 1798
[5] Bioorganic and Medicinal Chemistry, 2008, vol. 16, # 7, p. 3780 - 3790

4-METHYLINDOLE-3-CARBOXALDEHYDE Preparation Products And Raw materials

Raw materials

N,N-Dimethylformamide Nickel Phosphorus oxitrichloride N,N-Dimethyformamide diethy acetal 3-Nitro-o-xylene

Preparation Products

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4-METHYLINDOLE-3-CARBOXALDEHYDE Suppliers

China 95 Europe 1 India 2 Japan 1 Switzerland 2 United Kingdom 2 United States 14 Global 117
HBCChem, Inc.
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View Lastest Price from 4-METHYLINDOLE-3-CARBOXALDEHYDE manufacturers

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
Product
4-Methylindole-3-caboxaldehyde 4771-48-6
Price
US $1.60-6.60/kg
Min. Order
1kg
Purity
99%
Supply Ability
100kg
Release date
2025-06-19
Shaanxi Dideu Medichem Co. Ltd
Product
4-methyl-1H-indole-3-carbaldehyde 4771-48-6
Price
US $1.00-22.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
100000KG
Release date
2024-07-17
Career Henan Chemical Co
Product
4-METHYLINDOLE-3-CARBOXALDEHYDE 4771-48-6
Price
US $1.00/g
Min. Order
100EA
Purity
99%
Supply Ability
G/KG/T
Release date
2019-12-20

4771-48-6, 4-METHYLINDOLE-3-CARBOXALDEHYDERelated Search:

4-Methyloxazole-5-carbaldehyde 2-METHYLINDOLE-3-CARBOXALDEHYDE,2-Methylindole-3-carboxaldehyde, 97+% Arbidol hydrochloride 3-formyl-1H-Indole-4-carboxylic acid methyl ester 6-Methylindole-3-carboxaldehyde,98%,6-METHYLINDOLE-3-CARBOXALDEHYDE 5-Methylindole-3-carboxaldehyde 98%,5-METHYLINDOLE-3-CARBOXALDEHYDE 98% (HPLC),5-METHYLINDOLE-3-CARBOXALDEHYDE 1-METHYLINDOLE-3-CARBOXALDEHYDE 98% (HPLC),1-Methylindole-3-carboxaldehyde, 98+%,1-METHYLINDOLE-3-CARBOXALDEHYDE 7-METHYLINDOLE-3-CARBOXALDEHYDE,7-METHYLINDOLE-3-CARBOXALDEHYDE 98% (HPLC),7-Methylindole-3-carboxaldehyde 98% 5-METHOXY-1-METHYLINDOLE-3-CARBOXALDEHYDE 4-Methylindole 3,6A,11,14-TETRAHYDRO-9-METHOXY-2-METHYL-(12H)-ISOQUINO[1,2-B]PYRROLO[3,2-F][1,3]BENZOXAZINE-1-CARBOXYLIC ACID, ETHYL ESTER 5-Methoxy-4-methylindole-3-carboxaldehyde METHYL 6-N-BOC-AMINO-3-FORMYL-1H-INDOLE-4-CARBOXYLATE 3-FORMYL-1H-INDOLE-4-CARBONITRILE 4-METHYLINDOLE-3-CARBOXYLIC ACID 4-METHYLINDOLE-3-CARBOXALDEHYDE 2,4,6-TRIMETHYL-1H-INDOLE-3-CARBALDEHYDE 5-FLUORO-1-METHYLINDOLE-3-CARBOXALDEHYDE

  • 4-Methylindole-3-caboxaldehyde
  • 1H-Indole-3-carboxaldehyde, 4-methyl- (9CI)
  • 4-methyl-1H-indole-3-carbaldehyde(SALTDATA: FREE)
  • 4-Methyl-1H-indole-3-carboxaldehyde
  • 4-Methyl-3-indolecarboxaldehyde
  • 1H-Indole-3-carboxaldehyde, 4-Methyl-
  • 4-Methyl-3-carboxaldehyde
  • 4-METHYLINDOLE-3-ALDEHYDE
  • 4-METHYLINDOLE-3-CARBALDEHYDE
  • 4-METHYLINDOLE-3-CARBOXALDEHYDE
  • 4-METHYL-1H-INDOLE-3-CARBALDEHYDE
  • 4771-48-6
  • ALDEHYDE