Desmopressin acetate

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Desmopressin acetate

Product Name: Desmopressin acetate
CAS No.: 16789-98-3
Chemical Name: Desmopressin acetate
Synonyms: DDAVP;DDAVP ACETATE;Desmopressinum;LKT Desmopressin;Desmopressin (ADH);DESMORESSIN ACETATE;DDAVP, Desmopressin;DESMOPRESSIN ACETATE;DESMOPRESSIN MONOACETATE;DesMopressin (diacetate)
CBNumber: CB8386483
Molecular Formula: C48H68N14O14S2
Formula Weight: 1129.28
MOL File: 16789-98-3.mol

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Desmopressin acetate Property

Melting point:: 170-172°C (dec.)
storage temp.: −20°C
solubility: Acetic Acid (Slightly), Methanol (Slightly), Water (Slightly)
form: Solid
color: White to Off-White
InChIKey: MLSVJHOYXJGGTR-OZEDRGHLNA-N

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Safety

Hazard Codes: Xn
Risk Statements: 20
Safety Statements: 36
WGK Germany: 3
HS Code: 3504009000

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H317May cause an allergic skin reaction

H332Harmful if inhaled

H334May cause allergy or asthma symptoms or breathing difficulties if inhaled

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P314Get medical advice/attention if you feel unwell.

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N-Bromosuccinimide Price

Apolloscientific

Product number: BITH3012
Product name: DDAVP
Packaging: 5mg
Price: $185
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: API0002265
Product name: DESMOPRESSIN ACETATE
Purity: 95.00%
Packaging: 25MG
Price: $545
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: API0002265
Product name: DESMOPRESSIN ACETATE
Purity: 95.00%
Packaging: 50MG
Price: $690
Updated: 2021/12/16

Apolloscientific

Product number: BITH3012
Product name: DDAVP
Packaging: 25mg
Price: $732
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: API0002265
Product name: DESMOPRESSIN ACETATE
Purity: 95.00%
Packaging: 5MG
Price: $458
Updated: 2021/12/16

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Desmopressin acetate Chemical Properties,Usage,Production

Originator

DAV,Ritter,Switz.,1974

Uses

Antidiuretic.

Manufacturing Process

β-Benzylmercaptopropionyl-L-tyrosyl-L-phenylalanyl-L-glutaminyl-Lasparaginyl-S-benzyl-L-cysteinyl-L-prolyl-NG-tosyl-D-arginyl-glycinamide (0.5 g) is reduced with sodium in liquid ammonia. The liquid ammonia is then evaporated and the residue dissolved in 5% aqueous acetic acid (800 ml). The solution is filtered to remove the undissolved portion and the filtrate is adjusted to a pH of 6.5 to 7 by addition of aqueous sodium hydroxide and it is then oxidized by known procedure, cf. Kimbrough, R.D., Jr.; Cash, W.D.; Branda, L.A.; Chan, W.Y.; and Du Vigneaud, V.; J. Biol. Chem. 238,1411 (1963). The reaction mixture is thereupon adjusted to a pH of 4 to 4.5 by addition of acetic acid. The peptide is applied to a column of a carboxylate ion exchange resin, is eluted with 50% aqueous acetic acid and isolated by lyophilization (freeze-drying). The crude product is purified by known procedure using a carrier-free high-voltage electrophoresis, cf. Zaoral, M.; Sorm, F.; Collection Czechoslov. Chem Communs, 31, 310 (1966). Yield, 100 to 200 mg of 1-deamino-8-D-argine-vasopressin.

brand name

Concentraid (Ferring Pharmaceuticals); Ddavp (Sanofi Aventis); Stimate (ZLB Behring).

Therapeutic Function

Antidiuretic

General Description

Desmopressin acetate(DDAVP, Stimate) is synthetic 1-desamino-8-D-argininevasopressin. Its efficacy, ease of administration (intranasal),long duration of action, and lack of side effects make itthe drug of choice for the treatment of central diabetesinsipidus. It may also be administered intramuscularly orintravenously. It is preferred to vasopressin injectionand oral antidiuretics for use in children. It is indicatedin the management of temporary polydipsia and polyuriaassociated with trauma to, or surgery in, the pituitary region.

Clinical Use

Desmopressin, as its acetate salt, is a synthetic analogue of vasopressin in which the Nterminal Cys is devoid of its α-amino function (1-Deamino) and where Arg8 is present as its D-isomer (D-Arg8), thus the commercial acronym DDAVP. The presence of D-Arg and the absence of the N-terminal amine in the desmopressin structure have increased its half-life such that it is available for oral, parenteral, or nasal use. It is used by all three of these routes of administration to prevent or control polydipsia (excessive thirst), polyuria, and dehydration of patients with diabetes insipidus caused by a deficiency of vasopressin. It also has been approved for the treatment of nocturnal enuresis (bed-wetting), which is believed to be caused by an absence of the normal night time rise in vasopressin levels.
Desmopressin is known to cause an increase in both plasma factor VIII (antihemophilic factor) and plasminogen activator. It therefore is approved by the U.S. FDA for use, parenterally and nasally, in reducing spontaneous or trauma-induced bleeding episodes in patients with hemophilia A and type I Von Willebrand's disease, provided that their plasma factor VIII activity is greater than 5%. Stimate, the nasal spray used in treating patients with hemophilia A and type I Von Willebrand's disease, is 15-fold the concentration of DDAVP nasal spray; the latter is used in treating diabetes insipidus.

Safety

Desmopressin is generally well-tolerated in most patients. There are a few instances where patients require monitoring for adverse effects of the drug. Patients receiving desmopressin need monitoring for the occurrence of hyponatremia. Symptoms of hyponatremia include nausea, confusion, or altered mental status. As patients age, they should also be continually monitored for declining renal function, as the therapeutic index and clearance of the drug will change according to the renal function. There is no known antidote to an overdose of desmopressin. The most worrisome complication to result from an overdose is water intoxication. This condition would result in a delayed loss of consciousness and seizures in some instances. Patients require immediate admission to the intensive care unit to be monitored and have electrolyte correction.

Veterinary Drugs and Treatments

Desmopressin has been found to be useful in the treatment of central diabetes insipidus in small animals. It may be useful in treating Von Willebrand’s disease, but its short duration of activity (2 – 4 hours) in this condition, resistance development, and expense limit its usefulness for this disorder. Desmopressin may be useful perioperatively to reduce lymph node involvement and metastatic disease in canine mammary gland cancer.

Desmopressin acetate Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Desmopressin acetate manufacturers

Wuhan Cell Pharmaceutical Co., Ltd

Product: Desmopressin 16789-98-3
Price: US $1.00-9.90/g
Min. Order: 1g
Purity: 99%
Supply Ability: 100kg
Release date: 2023-04-07

hebei hongtan Biotechnology Co., Ltd

Product: Desmopressin Acetate 16789-98-3
Price: US $30.00/box
Min. Order: 1box
Purity: 98%
Supply Ability: 5000box
Release date: 2024-03-20

Wuhan Boyuan Import & Export Co., LTD

Product: Desmopressin Acetate 16789-98-3
Price: US $15.00-9.00/kg
Min. Order: 1kg
Purity: 99.50%
Supply Ability: 20tons
Release date: 2023-09-08

16789-98-3, Desmopressin acetateRelated Search:

Citric acid Folic acid Ethyl acetate Pancuronium bromide Glatiramer acetate Sodium acetate Methyl acetate Terlipressin acetate Vasopressin Butyl acetate Tocopheryl acetate Vinyl acetate Ethyl 2-(Chlorosulfonyl)acetate Cetrorelix acetate Potassium Acetate Argipressine DESMOPRESSIN ACETATE PH. EUR. Pralmorelin

DESMOPRESSIN MONOACETATE

DESMOPRESSIN ACETATE

DESMOPRESSIN ACETATE SALT

DESMORESSIN ACETATE

Mpr-Tyr-Phe-Gln-Asn-Cys-Pro-D-Arg-Gly-NH2(S-S:1-5)

1-(3-Mercaptopropionic acid)-8-D-arginine-vasopressin diacetate

1-Deamino-8-D-arginine-vasopressin diacetate

DDAVP

Desmopressin (ADH)

[deamino-Cys1, D-Arg8]-Vasopressin hydrate acetate salt

DDAVP, Desmopressin

N-[1-[(2-amino-2-oxoethyl)amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]-1-[[7-(2-amino-2-oxoethyl)-10-(3-amino-3-oxopropyl)-16-[(4-hydroxyphenyl)methyl]-6,9,12,15,18-pentaoxo-13-(p

Desmopressin Acetate(1:2)

LKT Desmopressin

Mpr-Tyr-Phe-Gln-Asn-Cys-Pro-D-Arg-Gly-NH2(S-S:1-6)

1-[4-(2-amino-2-keto-ethyl)-7-(3-amino-3-keto-propyl)-10-(benzyl)-13-(4-hydroxybenzyl)-3,6,9,12,15-pentaketo-18,19-dithia-2,5,8,11,14-pentazacycloicosane-1-carbonyl]-N-[1-[(2-amino-2-keto-ethyl)carbamoyl]-4-guanidino-butyl]pyrrolidine-2-carboxamide

N-[1-[(2-amino-2-oxoethyl)amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]-1-[4-(2-amino-2-oxoethyl)-7-(3-amino-3-oxopropyl)-13-[(4-hydroxyphenyl)methyl]-3,6,9,12,15-pentaoxo-10-(phenylmethyl)-18,19-dithia-2,5,8,11,14-pentazacycloicosane-1-carbonyl]pyrrolidine-2-carboxamide

N-[1-[(2-azanyl-2-oxo-ethyl)amino]-5-[bis(azanyl)methylideneamino]-1-oxo-pentan-2-yl]-1-[[4-(2-azanyl-2-oxo-ethyl)-7-(3-azanyl-3-oxo-propyl)-13-[(4-hydroxyphenyl)methyl]-3,6,9,12,15-pentaoxo-10-(phenylmethyl)-18,19-dithia-2,5,8,11,14-pentazacycloicos-1-yl]carbonyl]pyrrolidine-2-carboxamide

DesMopressin (diacetate)

DDAVP ACETATE

[DEAMINO-CYS1,D-ARG8]-VASOPRESSIN ACETATE SALT

Desmopressinum

3-MERCAPTOPROPIONYL-TYR-PHE-GLN-ASN-CYS-PRO-D-ARG-GLY-NH2 ACETATE SALT

DesmopressinAcetate(DDAVP)

Desmopressin acetate USP/EP/BP

Desmopressin(DDAVP) acetate

16789-98-3

C46H64N14O12S22C2H4O

C46H64N14O12S22C2H4O2

C46H63O14N14S2

Pituitary Hormones

Hormones

Cytokines, Growth Factors and Hormones

Cell Signaling and Neuroscience

Cell Biology

BioChemical

Peptide

hormones

16789-98-3