2-HYDROXY-5-NITRO-3-(TRIFLUOROMETHYL)PYRIDINE
- Product Name
- 2-HYDROXY-5-NITRO-3-(TRIFLUOROMETHYL)PYRIDINE
- CAS No.
- 33252-64-1
- Chemical Name
- 2-HYDROXY-5-NITRO-3-(TRIFLUOROMETHYL)PYRIDINE
- Synonyms
- 5-NITRO-3-(TRIFLUOROMETHYL)PYRIDIN-2-OL;3-NITRO-5-(TRIFLUOROMETHYL)PYRIDIN-2-OL;BUTTPARK 25\01-34;2-hydroxy-3-nitro-5-trifluoropyridine;5-NITRO-3-(TRIFLUOROMETHYL-2-PYRIDONE);3-NITRO-5-(TRIFLUOROMETHYL)-2-PYRIDONE;3-Nitro-5-(trifluoroMethyl)pyridin-2-o;3-NITRO-5-TRIFLUOROMETHYL-2-PYRIDINONE;5-(trifluoromethyl)-3-nitropyridin-2-ol;3-Nitro-5-(trifluoromethyl)-2-pyridinol
- CBNumber
- CB8395090
- Molecular Formula
- C6H3F3N2O3
- Formula Weight
- 208.09
- MOL File
- 33252-64-1.mol
2-HYDROXY-5-NITRO-3-(TRIFLUOROMETHYL)PYRIDINE Property
- Melting point:
- 189 °C
- Boiling point:
- 276.2±40.0 °C(Predicted)
- Density
- 1.61±0.1 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- pka
- 5.89±0.10(Predicted)
- form
- Solid
- color
- Off-white
- InChI
- InChI=1S/C6H3F3N2O3/c7-6(8,9)3-1-4(11(13)14)5(12)10-2-3/h1-2H,(H,10,12)
- InChIKey
- JYXKHKBZLLIWEV-UHFFFAOYSA-N
- SMILES
- C1(=O)NC=C(C(F)(F)F)C=C1[N+]([O-])=O
- CAS DataBase Reference
- 33252-64-1(CAS DataBase Reference)
Safety
- Hazard Codes
- Xi
- Risk Statements
- 20/21/22-36/37/38
- Safety Statements
- 22-26-36/37/39
- RIDADR
- NA3077
- Hazard Note
- Irritant
- HazardClass
- 6.1
- HS Code
- 2933399990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H312Harmful in contact with skin
H315Causes skin irritation
H319Causes serious eye irritation
H332Harmful if inhaled
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- N900918
- Product name
- 3-Nitro-5-(trifluoromethyl)pyridin-2(1H)-one
- Packaging
- 50mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- PC4861
- Product name
- 2-Hydroxy-3-nitro-5-(trifluoromethyl)pyridine
- Purity
- 98%
- Packaging
- 1g
- Price
- $17
- Updated
- 2021/12/16
- Product number
- 4H54-3-23
- Product name
- 2-Hydroxy-3-nitro-5-(trifluoromethyl)pyridine
- Purity
- 98%
- Packaging
- 1g
- Price
- $28
- Updated
- 2021/12/16
- Product number
- 001464
- Product name
- 2-Hydroxy-3-nitro-5-(trifluoromethyl)pyridine
- Purity
- 98%
- Packaging
- 5g
- Price
- $62
- Updated
- 2021/12/16
- Product number
- J50583
- Product name
- 2-Hydroxy-3-nitro-5-(trifluoromethyl)pyridine
- Packaging
- 5g
- Price
- $62
- Updated
- 2021/12/16
2-HYDROXY-5-NITRO-3-(TRIFLUOROMETHYL)PYRIDINE Chemical Properties,Usage,Production
Synthesis
33252-63-0
33252-64-1
The general procedure for the synthesis of 2-hydroxy-3-nitro-5-trifluoromethylpyridine using 2-hydroxy-5-trifluoromethylpyridine as starting material was as follows: 2-hydroxy-5-trifluoromethylpyridine (10.0 g, 61.3 mmol) was dissolved in concentrated sulfuric acid (50 mL), and the reaction system was cooled to 0 °C. Fuming nitric acid (14 mL, 92 mmol) was slowly added dropwise at 0 °C. After the dropwise addition, the reaction was kept at 0 °C and continued to be stirred for 1 h. Subsequently, the temperature of the reaction was raised to 65 °C and the reaction was continued to be stirred for 24 h. The reaction temperature was increased to 65 °C and the reaction was continued to be stirred. After completion of the reaction, the reaction system was cooled to room temperature and the reaction was quenched by slowly pouring into ice (300 g). Subsequently, 50% aqueous sodium hydroxide solution (85 mL) was slowly added to neutralize the reaction mixture. The aqueous phase was extracted several times with ethyl acetate (4 x 200 mL), all organic phases were combined, dried with anhydrous magnesium sulfate, filtered and concentrated under reduced pressure to give a yellow solid 2-hydroxy-3-nitro-5-trifluoromethylpyridine 7.4 g in 58% yield. The product was characterized by 1H NMR (CDCl3): δ 8.66 (s, 1H), 8.29 (s, 1H).
References
[1] Patent: WO2009/7418, 2009, A1. Location in patent: Page/Page column 23
[2] Patent: CN105111209, 2017, B. Location in patent: Paragraph 0029; 0036
[3] Patent: US2006/4018, 2006, A1. Location in patent: Page/Page column 14; 35
[4] Patent: WO2011/43404, 2011, A1. Location in patent: Page/Page column 111-112
[5] Bioorganic and Medicinal Chemistry Letters, 2013, vol. 23, # 13, p. 3983 - 3987
2-HYDROXY-5-NITRO-3-(TRIFLUOROMETHYL)PYRIDINE Preparation Products And Raw materials
Raw materials
Preparation Products
2-HYDROXY-5-NITRO-3-(TRIFLUOROMETHYL)PYRIDINE Suppliers
- Tel
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- Fax
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- sales@riccichimica.com
- Country
- Italy
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- 2146
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View Lastest Price from 2-HYDROXY-5-NITRO-3-(TRIFLUOROMETHYL)PYRIDINE manufacturers
- Product
- 3-Nitro-5-(trifluoromethyl)-2-pyridinol 33252-64-1
- Price
- US $1.10-9.90/KG
- Min. Order
- 1KG
- Purity
- 99% min
- Supply Ability
- 100kg
- Release date
- 2025-08-18
- Product
- 2-HYDROXY-5-NITRO-3-(TRIFLUOROMETHYL)PYRIDINE 33252-64-1
- Price
- US $0.10/KG
- Min. Order
- 1KG
- Purity
- 99.0%
- Supply Ability
- 1000 tons
- Release date
- 2024-08-04
- Product
- 3-Nitro-5-(trifluoromethyl)-2-pyridinol 33252-64-1
- Price
- US $0.00/kg
- Min. Order
- 25kg
- Purity
- 98%
- Supply Ability
- Inquiry
- Release date
- 2023-07-14