ChemicalBook > CAS DataBase List > Fenofibric acid

Fenofibric acid

Product Name
Fenofibric acid
CAS No.
42017-89-0
Chemical Name
Fenofibric acid
Synonyms
FENOFIBRATE ACID;lf153;A-1081;FNF Acid;alpha1081;lf178acid;NSC 281318;EP-B/USP RC B;FENOFIBRIC ACID;FeNAfibric acid
CBNumber
CB8400259
Molecular Formula
C17H15ClO4
Formula Weight
318.75
MOL File
42017-89-0.mol
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Fenofibric acid Property

Melting point:
177-179°C
Boiling point:
486.5±35.0 °C(Predicted)
Density 
1.286±0.06 g/cm3(Predicted)
storage temp. 
2-8°C
solubility 
Chloroform (Slightly), Methanol (Slightly)
pka
3.09±0.10(Predicted)
form 
powder
color 
White to Off-White
BRN 
2058973
InChI
InChI=1S/C17H15ClO4/c1-17(2,16(20)21)22-14-9-5-12(6-10-14)15(19)11-3-7-13(18)8-4-11/h3-10H,1-2H3,(H,20,21)
InChIKey
MQOBSOSZFYZQOK-UHFFFAOYSA-N
SMILES
C(O)(=O)C(OC1=CC=C(C(=O)C2=CC=C(Cl)C=C2)C=C1)(C)C
CAS DataBase Reference
42017-89-0(CAS DataBase Reference)
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Safety

Hazard Codes 
Xn,N
Risk Statements 
36/37/38-50/53-22
Safety Statements 
26-36/37/39-61-60-24/25
RIDADR 
UN 3077 9 / PGIII
WGK Germany 
3
RTECS 
UA2453000
HazardClass 
9
PackingGroup 
III
HS Code 
29189900
Toxicity
LD50 oral in rat: 1242mg/kg
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H410Very toxic to aquatic life with long lasting effects

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P273Avoid release to the environment.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P391Collect spillage. Hazardous to the aquatic environment

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
PHR3315
Product name
Fenofibrate Related Compound B
Purity
certified reference material, pharmaceutical secondary standard
Packaging
50MG
Price
$592
Updated
2025/07/31
Sigma-Aldrich
Product number
F0048010
Product name
Fenofibrate impurity B
Purity
European Pharmacopoeia (EP) Reference Standard
Packaging
20 mg
Price
$164
Updated
2025/07/31
Sigma-Aldrich
Product number
796565
Product name
Fenofibric acid
Purity
95%
Packaging
1g
Price
$51.3
Updated
2025/07/31
Sigma-Aldrich
Product number
1269618
Product name
Fenofibrate Related Compound B
Purity
United States Pharmacopeia (USP) Reference Standard
Packaging
25mg
Price
$1300
Updated
2025/07/31
Sigma-Aldrich
Product number
1269436
Product name
Fenofibric Acid
Purity
United States Pharmacopeia (USP) Reference Standard
Packaging
250mg
Price
$585
Updated
2025/07/31
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Fenofibric acid Chemical Properties,Usage,Production

Chemical Properties

Fenofibric acid is a white to almost white crystalline powder that is stable under ordinary conditions and has a melting point of 179 – 183°C. Its empirical formula is C17H15ClO4 and molecular weight 318.75. Fenofibric acid is insoluble in water; its solubility increases with pH in buffered media.

Uses

Fenofibric acid, the active metabolite of fenofibrate. Increases Apolipoprotein A-Iediated High-Density Lipoprotein Biogenesis by enhancing transcription of ATP-Binding cassette transporter A1 gene in a liver X receptorependent manner

Uses

Fenofibric acid, the active metabolite of fenofibrate. Increases Apolipoprotein A-I–Mediated High-Density Lipoprotein Biogenesis by enhancing transcription of ATP-Binding cassette transporter A1 gene in a liver X receptor–dependent manner.

Uses

DPP4 inhibitor, antidiabetic

Definition

ChEBI: A monocarboxylic acid that is 2-methylpropanoic acid substituted by a 4-(4-chlorobenzoyl)phenoxy group at position 2. It is a metabolite of the drug fenofibrate.

Synthesis

1159999-13-9

42017-89-0

General procedure for the synthesis of fenofibric acid from compound (CAS:1159999-13-9): to a solution of compound 104 (5.00 g, 12.2 mmol) in ethanol (150 mL) was added a solution of potassium hydroxide (2.74 g, 48.9 mmol) in ethanol (50 mL). The reaction mixture was heated to reflux and stirred for 16 hours. Upon completion of the reaction, ethanol was removed under vacuum and water (200 mL) was added to the residue. The aqueous solution was washed with ether (2 x 100 mL) to remove nonpolar impurities, followed by acidification of the aqueous solution with 2N HCl to pH 1. The acidified aqueous solution was extracted with ethyl acetate (2 x 150 mL), the organic phases were combined, washed with brine, dried over anhydrous sodium sulfate, filtered, and concentrated under vacuum to give compound 105 (3.57 g, 91% yield) as an off-white solid . The product was characterized by 1H NMR (300 MHz, CD3OD): δ 7.75-7.70 (m, 4H), 7.52 (d, J = 8.6 Hz, 2H), 6.96 (d, J = 9.0 Hz, 2H), 1.65 (s, 6H).

Metabolism

Fenofibric acid is primarily conjugated with glucuronic acid and then excreted in urine. A small amount of fenofibric acid is reduced at the carbonyl moiety to a benzhydrol metabolite, which is, in turn, conjugated with glucuronic acid and excreted in urine. In vitro and in vivo metabolism data indicate that fenofibric acid does not undergo oxidative metabolism (e.g. cytochrome P450) to a significant extent. The enzymes CYP1A2, CYP2A6, CYP2B6, CYP2C8, CYP2C9, CYP2C19, CYP2D6, CYP2E1, and CYP3A4 do not play a role in the metabolism of fenofibric acid.

References

[1] Patent: WO2009/73138, 2009, A2. Location in patent: Page/Page column 81-82

Fenofibric acid Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Fenofibric acid manufacturers

Hebei Chuanghai Biotechnology Co., Ltd
Product
Fenofibric acid 42017-89-0
Price
US $10.00/KG
Min. Order
100KG
Purity
99%
Supply Ability
100 mt
Release date
2024-12-02
HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD
Product
Fenofibric acid 42017-89-0
Price
US $99.00-66.00/kg
Min. Order
0.00100000kg
Purity
99%
Supply Ability
5000
Release date
2024-08-12
Hebei Zhuanglai Chemical Trading Co.,Ltd
Product
Fenofibric Acid 42017-89-0
Price
US $180.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
20ton
Release date
2024-06-05

42017-89-0, Fenofibric acidRelated Search:

2-[4-(4-Chlorobenzoyl)phenoxy]-2-methylpropionic acid methyl ester (4-Chlorophenyl)[4-(1-Methylethoxy)phenyl]Methanone (Fenofibrate IMpurity) FENOFIBRATE RELATED COMPOUND C (25 MG) (1-METHYLETHYL 2-[[2-[4-(4-CHLOROBENZOYL)PHENOXY]-2-METHYLPROPANOYL]OXY]-2-METHYLPROPANOATE) Ethyl 2-(Chlorosulfonyl)acetate Dimethyldimethoxysilane Methyltriethoxysilane Methyltrimethoxysilane Stearic acid Folic acid Ethoxymethylenemalononitrile Fenofibrate 2,2-Bis(hydroxymethyl)propionic acid 4-Chloro-4'-hydroxybenzophenone 3-[4-(4-Chlorobenzoyl)phenoxy]-2-butanone (Fenofibrate IMpurity) Diethyl squarate Citric acid Choline Fenofibrate Squaric acid

  • 2-[4-(4-CHLOROBENZOYL)PHENOXY]-2-METHYLPROPANOIC ACID
  • LABOTEST-BB LT00239222
  • FENOFIBRIC ACID
  • SALOR-INT L498335-1EA
  • 2-[4-(4-CHLORO-BENZOYL)-PHENOXY]-2-METHYL-PROPIONIC ACID (FENOFIBRIC ACID)
  • 2-[4-(4-CHLOROBENBONYZOYL)PHENOXY)-2-METHYLPROPIONIC ACID
  • 2-[4'-(p-Chlorobenzoyl)phenoxy]-2-methylpropionic acid
  • FENOFIBRATE ACID
  • A-1081
  • Fenofibrate Related Compound B (25 mg) (2-(4-(4-chlorobenzoyl)phenoxy)-2-methylpropanoic acid)
  • Choline Fenofibrate Impurity B
  • Fenofibrate Impurity 2(Fenofibrate EP Impurity B)
  • Fenofibrate impurity B (EP)
  • alpha1081
  • 2-(4-(4-chlorobenzoyl)phenoxy)-2-methyl-propanoicaci
  • 2-[4-[(4-chlorophenyl)-oxomethyl]phenoxy]-2-methylpropanoate
  • FeNAfibric acid
  • Fenofibrate EP IMpurity B
  • 2-(4-(4-Chlorobenzoyl)phenoxy)-2-Methylpropanoic acid, 95+%
  • FNF Acid
  • NSC 281318
  • Fenofibric acid, >=99%
  • 2-[4-(4-Chlorobenzoyl)phenoxy]-2-methylpropionic acid 95%
  • lf153
  • lf178acid
  • procetofenicacid
  • 2-[4-(4-CHLORO-BENZOYL)-PHENOXY]-2-METHYL-PROPIONIC ACID
  • 2-[4-(4-CHLOROBENZOYL) PHENOXY]-2'-METHYL PROPANOIC ACID
  • Fenofibrate Impurity Ⅱ:Fenofibric acid(2-[4-(4-chlorobenzoyl)phenoxy]-2-methylpropionic acid)
  • FenofibricAcid&gt
  • Fenofibrate impurity B CRS
  • Fenofibrate EP Impurity B (Fenofibric Acid)
  • Propanoic acid, 2-[4-(4-chlorobenzoyl)phenoxy]-2-methyl-
  • Fenofibrate USP Related Compound B
  • Fenofibrate EP Impurity B/ Fenofibrate Related Compound B (Fenofibric Acid)
  • Fenofibrate impurity B (F0048010)
  • Fenofibric acid D4
  • Fenofibric AcidQ: What is Fenofibric Acid Q: What is the CAS Number of Fenofibric Acid Q: What is the storage condition of Fenofibric Acid Q: What are the applications of Fenofibric Acid
  • Fenofibrate Related Compound B (2-(4-(4-chlorobenzoyl)phenoxy)-2-methylpropanoic acid) (1269618)
  • Choline Fenofibrate EP Impurity B
  • Fenofibric acid,2-[4-(4-Chlorobenzoyl)phenoxy]-2-methylpropionic acid
  • EP-B/USP RC B
  • Fenofibric acid 100 μg/ml Acetone
  • Fenofibrate Related Compound II（2-[4-（4-chlorobenzoyl)phenoxy]-2-methylpropanoic acid
  • 2-[4-(4-Chlorobenzoyl)phenoxy]-2-methylpropanoic Acid (Fenofibric Acid)
  • Fenofibric acid, 10 mM in DMSO
  • Fenofibric acid 100 μg/mL in Acetonitrile
  • Fenofibrate Imp. B (EP): 2-[4-(4-Chlorobenzoyl)phenoxy-2-methylpropanoic Acid
  • 42017-89-0
  • C17H14ClO4
  • C20H21CL04
  • JANUVIA
  • Various Metabolites and Impurities
  • Intermediates & Fine Chemicals
  • Metabolites & Impurities
  • Pharmaceuticals
  • pharmacetical
  • Aromatics