2-Bromo-4-fomylthiazole
Application- Product Name
- 2-Bromo-4-fomylthiazole
- CAS No.
- 5198-80-1
- Chemical Name
- 2-Bromo-4-fomylthiazole
- Synonyms
- 2-BROMOTHIAZOLE-4-CARBALDEHYDE;B2070m500;2-Bromo-4-fomylthiazole;2-BROMO-4-FORMYLTHIAZOLE;2-BROMO-4-CARBOXYTHIAZOLE;2-Bromo-4-formyl-1,3-thiazole;2-Bromothiazol-4-carbaxaldehyde;2-broMo-4-Thiazolecarboxaldehyde;4-Thiazolecarboxaldehyde, 2-bromo-;2-bromo-1,3-thiazole-4-carbaldehyde
- CBNumber
- CB8412519
- Molecular Formula
- C4H2BrNOS
- Formula Weight
- 192.03
- MOL File
- 5198-80-1.mol
2-Bromo-4-fomylthiazole Property
- Melting point:
- 132-135
- Boiling point:
- 264.9±13.0 °C(Predicted)
- Density
- 1.920±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- pka
- -1.37±0.10(Predicted)
- form
- Crystalline Powder
- color
- White to yellow
- InChI
- InChI=1S/C4H2BrNOS/c5-4-6-3(1-7)2-8-4/h1-2H
- InChIKey
- MNQVIZWWCRPZOK-UHFFFAOYSA-N
- SMILES
- S1C=C(C=O)N=C1Br
Safety
- Hazard Codes
- Xi,Xn
- Risk Statements
- 22-41-43
- Safety Statements
- 26-36/37-39
- WGK Germany
- 3
- Hazard Note
- Irritant/Store Cold
- TSCA
- No
- HS Code
- 29341000
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H302Harmful if swallowed
H317May cause an allergic skin reaction
H318Causes serious eye damage
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
N-Bromosuccinimide Price
- Product number
- 756873
- Product name
- 2-Bromothiazole-4-carboxaldehyde
- Packaging
- 500mg
- Price
- $37.8
- Updated
- 2023/06/20
- Product number
- B415063
- Product name
- 2-Bromothiazole-4-carbaldehyde
- Packaging
- 50mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- B11170
- Product name
- 2-Bromo-4-formylthiazole
- Purity
- 98%
- Packaging
- 1g
- Price
- $25
- Updated
- 2021/12/16
- Product number
- OR1863
- Product name
- 2-Bromo-1,3-thiazole-4-carboxaldehyde
- Packaging
- 1g
- Price
- $35
- Updated
- 2021/12/16
- Product number
- 8H70-9-Y6
- Product name
- 2-Bromo-1,3-thiazole-4-carboxaldehyde
- Packaging
- 1g
- Price
- $39
- Updated
- 2021/12/16
2-Bromo-4-fomylthiazole Chemical Properties,Usage,Production
Application
2-Bromo-4-aldehydethiazole is a heterocyclic organic compound that can be used as a pharmaceutical intermediate.
Synthesis
5198-86-7
5198-80-1
General procedure for the synthesis of 2-bromo-4-formylthiazole from 2-bromothiazole-4-methanol: 0.22 mol of dimethylsulfoxide was dissolved in 50 mL of dichloromethane and added slowly and dropwise to 200 mL of dichloromethane solution containing 0.11 mol of oxalyl chloride over a temperature range of -75 to -65 °C. The reaction mixture was stirred at this temperature for 30 minutes. Subsequently, 0.1 mol 2-bromothiazole-4-methanol was slowly added dropwise to a 100 mL dichloromethane solution at the same temperature range. After the dropwise addition was completed, the reaction mixture continued to be stirred at -75 to -65°C for 2 hours. Next, 0.5 mol of triethylamine was slowly added dropwise while keeping the temperature constant. The temperature of the reaction mixture was gradually increased to -10 °C and maintained at this temperature for 1 hour. Upon completion of the reaction, the mixture was poured into 400 mL of aqueous solution containing 0.4 mol of sodium bicarbonate and stirred for 30 minutes. The aqueous phase was extracted with dichloromethane, the organic layers were combined and dried over anhydrous sodium sulfate. The solvent was removed by concentration under reduced pressure and the resulting residue was purified by column chromatography.
References
[1] Russian Journal of General Chemistry, 2017, vol. 87, # 12, p. 2766 - 2775
[2] Zh. Obshch. Khim., 2017, vol. 87, # 12, p. 1947 - 1956,10
[3] Patent: WO2017/184624, 2017, A1. Location in patent: Page/Page column 185; 186
2-Bromo-4-fomylthiazole Preparation Products And Raw materials
Raw materials
Preparation Products
2-Bromo-4-fomylthiazole Suppliers
- Tel
- --
- Fax
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- Sales@casorganic.com
- Country
- Ukraine
- ProdList
- 5026
- Advantage
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View Lastest Price from 2-Bromo-4-fomylthiazole manufacturers
- Product
- 2-Bromo-4-fomylthiazole 5198-80-1
- Price
- US $1.50/g
- Min. Order
- 1g
- Purity
- 99.0% Min
- Supply Ability
- 10 Tons
- Release date
- 2025-06-24
- Product
- 2-Bromo-4-fomylthiazole 5198-80-1
- Price
- US $9.80/KG
- Min. Order
- 1g
- Purity
- ≥99%
- Supply Ability
- 100kg
- Release date
- 2020-01-08