4-Amino-6-chloro-5-methoxypyrimidine

Product Name: 4-Amino-6-chloro-5-methoxypyrimidine
CAS No.: 5018-41-7
Chemical Name: 4-Amino-6-chloro-5-methoxypyrimidine
Synonyms: 6-CHLORO-5-METHOXYPYRIMIDIN-4-AMINE;6-Chloro-5-methoxy-4-pyrimidinamine;4-Amino-6-Chloro-5-Methoxy Pyrimidin;4-AMINO-6-CHLORO-5-METHOXYPYRIMIDINE;6-Chloro-5-MethoxypyriMidin-4-ylaMine;4-Pyrimidinamine, 6-chloro-5-methoxy-;4-Amino-6-chloro-5-methoxypyrimidine ISO 9001：2015 REACH;4-(p-AMinobenzene SulfonaMino)-5Methoxy-6-Chloro PyriMidine)
CBNumber: CB8433466
Molecular Formula: C5H6ClN3O
Formula Weight: 159.57
MOL File: 5018-41-7.mol

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4-Amino-6-chloro-5-methoxypyrimidine Property

Melting point:: 176-178 °C
Boiling point:: 305.4±37.0 °C(Predicted)
Density: 1.398±0.06 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2–8 °C
pka: 1.51±0.10(Predicted)
Appearance: White to off-white Solid
InChI: InChI=1S/C5H6ClN3O/c1-10-3-4(6)8-2-9-5(3)7/h2H,1H3,(H2,7,8,9)
InChIKey: AAJZJNHQPBMCFV-UHFFFAOYSA-N
SMILES: C1=NC(Cl)=C(OC)C(N)=N1
CAS DataBase Reference: 5018-41-7(CAS DataBase Reference)

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Safety

HS Code: 2933599590

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

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N-Bromosuccinimide Price

TRC

Product number: A595470
Product name: 4-Amino-6-chloro-5-methoxypyrimidine
Packaging: 500mg
Price: $155
Updated: 2021/12/16

AK Scientific

Product number: L625
Product name: 4-Amino-6-chloro-5-methoxypyrimidine
Packaging: 100mg
Price: $95
Updated: 2021/12/16

Matrix Scientific

Product number: 101625
Product name: 4-Amino-5-methoxy-6-chloropyrimidine
Purity: 98%
Packaging: 1g
Price: $139
Updated: 2021/12/16

Matrix Scientific

Product number: 101625
Product name: 4-Amino-5-methoxy-6-chloropyrimidine
Purity: 98%
Packaging: 5g
Price: $374
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: HCH0012845
Product name: 4-AMINO-6-CHLORO-5-METHOXYPYRIMIDINE
Purity: 95.00%
Packaging: 1G
Price: $970.2
Updated: 2021/12/16

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4-Amino-6-chloro-5-methoxypyrimidine Chemical Properties,Usage,Production

Synthesis

5018-38-2

5018-41-7

General procedure for the synthesis of 4-sulfo-5-methoxy-6-chloropyrimidine from 4,6-dichloro-5-methoxypyrimidine: a mixture of 4,6-dichloro-5-methoxypyrimidine (5.0 g, 28.1 mmol), 30% ammonia (45 mL), and n-butanol (15 mL) was heated and reacted in a sealed tube for 8 hr at 85 °C. Upon completion of the reaction, the reaction mixture was concentrated under reduced pressure and the concentrate was subsequently suspended in brine (150 mL). A white precipitate was collected by filtration and the filter cake was recrystallized from ethanol to afford the target compound 4-sulfo-5-methoxy-6-chloropyrimidine as an off-white solid in a yield of 4.1 g in 90% yield. The product was characterized by 1H NMR (400 MHz, DMSO-d6): δ 7.97 (s, 1H), 7.29 (s, 2H), 3.71 (s, 3H). Mass spectrum (ESI, cation mode) showed m/z: 159.91 [M + H]+.

References

[1] European Journal of Medicinal Chemistry, 2018, vol. 143, p. 1148 - 1164
[2] Patent: CN108164548, 2018, A. Location in patent: Paragraph 0209; 0210; 0211
[3] Organic Process Research and Development, 2015, vol. 19, # 6, p. 639 - 645
[4] Patent: WO2005/47279, 2005, A1. Location in patent: Page/Page column 33

4-Amino-6-chloro-5-methoxypyrimidine Preparation Products And Raw materials

Raw materials

Preparation Products

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4-Amino-6-chloro-5-methoxypyrimidine Suppliers

Canada 1 China 115 India 2 Slovakia 1 Ukraine 1 United Kingdom 4 United States 15 Global 139

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View Lastest Price from 4-Amino-6-chloro-5-methoxypyrimidine manufacturers

Shaanxi Dideu Medichem Co. Ltd

Product: 4-Amino-6-chloro-5-methoxypyrimidine 5018-41-7
Price: US $1.10/g
Min. Order: 1g
Purity: 99.0% min
Supply Ability: 100 tons min
Release date: 2021-05-13

Career Henan Chemical Co

Product: 4-Amino-6-chloro-5-methoxypyrimidine 5018-41-7
Price: US $8.80/KG
Min. Order: 1KG
Purity: 97%-99%
Supply Ability: 100kg
Release date: 2019-07-09

5018-41-7, 4-Amino-6-chloro-5-methoxypyrimidineRelated Search:

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4-Amino-6-chloro-5-methoxypyrimidine ISO 9001：2015 REACH

5018-41-7

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Pyrimidine