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4-Chloro-4'-hydroxybenzophenone

Product Name
4-Chloro-4'-hydroxybenzophenone
CAS No.
42019-78-3
Chemical Name
4-Chloro-4'-hydroxybenzophenone
Synonyms
4-CHLORO-4-HYDROXYBENZOPHENONE;NSC4056;NSC 4056;NSC-4056;4-Chloro-4'-;4-Chloro-4'EP-A /USP RC A;4-Chloro-4'-hydroxyb;-hydroxybenzophenone;LABOTEST-BB LT00248477
CBNumber
CB8435031
Molecular Formula
C13H9ClO2
Formula Weight
232.66
MOL File
42019-78-3.mol
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4-Chloro-4'-hydroxybenzophenone Property

Melting point:
177-181 °C
Boiling point:
257 °C (13 mmHg)
Density 
1.2082 (rough estimate)
refractive index 
1.5434 (estimate)
Flash point:
100 °C
storage temp. 
Inert atmosphere,Room Temperature
solubility 
DMSO (Slightly), Methanol (Slightly, Sonicated)
pka
7.68±0.15(Predicted)
color 
Pale Beige to Light Brown
BRN 
2049956
CAS DataBase Reference
42019-78-3(CAS DataBase Reference)
NIST Chemistry Reference
Methanone, (4-chlorophenyl)(4-hydroxyphenyl)-(42019-78-3)
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Safety

Hazard Codes 
Xi,Xn
Risk Statements 
36/37/38-20/21/22
Safety Statements 
24/25-37/39-26-36
Hazard Note 
Irritant
HS Code 
29144000
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
PHR2864
Product name
Fenofibrate Related Compound A
Purity
Pharmaceutical Secondary Standard; Certified Reference Material
Packaging
50MG
Price
$718
Updated
2024/03/01
Sigma-Aldrich
Product number
F0048005
Product name
Fenofibrate impurity A
Purity
European Pharmacopoeia (EP) Reference Standard
Packaging
f0048005
Price
$153
Updated
2024/03/01
Sigma-Aldrich
Product number
1269607
Product name
Fenofibrate Related Compound A
Purity
United States Pharmacopeia (USP) Reference Standard
Packaging
25mg
Price
$894
Updated
2024/03/01
TCI Chemical
Product number
C1155
Product name
4-Chloro-4'-hydroxybenzophenone
Purity
>98.0%(GC)
Packaging
25g
Price
$75
Updated
2024/03/01
TCI Chemical
Product number
C1155
Product name
4-Chloro-4'-hydroxybenzophenone
Purity
>98.0%(GC)
Packaging
500g
Price
$576
Updated
2024/03/01
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4-Chloro-4'-hydroxybenzophenone Chemical Properties,Usage,Production

Chemical Properties

light grey to beige-brown powder

Uses

4-Chloro-4’-hydroxybenzophenone (Fenofibrate EP Impurity A; Fenofibrate USP Related Compound A) the impurity of Fenofibric acid (42017-89-0), the active metabolite of fenofibrate which increases Apolipoprotein A-I–Mediated High-Density Lipoprotein Biogenesis by enhancing transcription of ATP-Binding cassette transporter A1 gene in a liver X receptor–dependent manner.

Preparation

Preparation by Fries rearrangement of phenyl p-chloro-benzoate,
? in the presence of aluminium chloride, without solvent, at 160° for 5 min, between 120° and 160° (good yield) or at 130° for 1 h, then at 160° for 1 h (10%) or in refluxing chlorobenzene for 10 h (52%);
? in the presence of trifluoromethanesulfonic acid at 45–55° (94%).

4-Chloro-4'-hydroxybenzophenone Preparation Products And Raw materials

Raw materials

Anisole Aluminum chloride 4-Chlorobenzoyl chloride

Preparation Products

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4-Chloro-4'-hydroxybenzophenone Suppliers

Americas 1 Belgium 1 Canada 4 China 378 Europe 4 France 2 Germany 5 India 81 Japan 6 Slovakia 1 South Korea 1 Spain 1 Switzerland 3 Ukraine 1 United Kingdom 16 United States 50 Global 555
TCI Europe
Tel
320-37350700
Fax
+32 (0)37350701
Email
sales@tcieurope.eu
Country
Europe
ProdList
23680
Advantage
75
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View Lastest Price from 4-Chloro-4'-hydroxybenzophenone manufacturers

Ouhuang Engineering Materials (Hubei) Co., Ltd
Product
4-p-Chlorobenzoylphenol 42019-78-3
Price
US $30.00/kg
Min. Order
1kg
Purity
99.7%
Supply Ability
200000kg
Release date
2024-04-22
Wuhan Boyuan Import & Export Co., LTD
Product
4-Chloro-4′-Hydroxybenzophenone 42019-78-3
Price
US $15.00-10.00/g
Min. Order
1g
Purity
99.50%
Supply Ability
10kg
Release date
2023-06-25
WUHAN FORTUNA CHEMICAL CO., LTD
Product
4-Chloro-4'-hydroxybenzophenone 42019-78-3
Price
US $0.00/KG
Min. Order
1KG
Purity
98%min
Supply Ability
30tons/month
Release date
2023-02-25

42019-78-3, 4-Chloro-4'-hydroxybenzophenoneRelated Search:

4-Hydroxybenzophenone 4-Chlorobenzophenone 3,4-Dihydroxybenzophenone Glycolic acid 4,4'-Dihydroxybenzophenone 4-Hydroxybenzaldehyde 2,4-Dihydroxybenzophenone Benzophenone Hydroxy silicone oil Hydroxyapatite Fenofibric acid Fenofibrate FENOFIBRATE RELATED COMPOUND C (25 MG) (1-METHYLETHYL 2-[[2-[4-(4-CHLOROBENZOYL)PHENOXY]-2-METHYLPROPANOYL]OXY]-2-METHYLPROPANOATE) (4-Chlorophenyl)[4-(1-Methylethoxy)phenyl]Methanone (Fenofibrate IMpurity) 2-[4-(4-Chlorobenzoyl)phenoxy]-2-methylpropionic acid methyl ester Unii-4bmh7izt98 3-[4-(4-Chlorobenzoyl)phenoxy]-2-butanone (Fenofibrate IMpurity) FENOFIBRIC ACID ETHYL ESTER

  • 4-hydroxy-4’-chloro-benophenone
  • Fenofibrate Impurity Ⅰ:4-Chloro-4'-hydroxybenzophenone
  • 4-Chloro-4'-Hydroxybenzophenone 4-Hydroxy-4'-Chlorobenzophenone
  • 4-p-Chlorobenzoylphenol
  • 4-(4-Chlorobenzoyl)-4-Hydroxypiperidine
  • 4-(4-CHLOROBENZOYL)PHENOL
  • 4-Chloro-4'-hydroxybenzophenon
  • LABOTEST-BB LT00248477
  • METHANONE, (4-CHLOROPHENYL)(4-HYDROXYPHENYL)-
  • 4-CHLORO-4'-HYDROXYBENZOPHENONE
  • 4-CHLORO-4-HYDROXYBENZOPHENONE
  • 4-HYDROXY-4'-CHLOROBENZOPHENONE
  • (4-CHLORO-PHENYL)-(4-HYDROXY-PHENYL)-METHANONE
  • 4-CHLORO-4''-HYDROXYBENZOPHENONE=99.0%
  • 8) 4-CHLORO 4-HYDROXY BENZOPHENONE
  • 4-CHLORO-4''-HYDROXYBENZOPHENONEFENOFIBRATE
  • 4,4'-Chlorohydroxybenzophenone
  • 4-Chloro-4'-hydroxybenzophenone,98%
  • 4-Chloro-4'-hydroxyb
  • Fenofibrate Related Compound A (25 mg) ((4-chlorophenyl)(4-hydroxyphenyl)methanone)
  • (4-chlorophenyl)(4-hydroxyphenyl)MethaNAne
  • Fenofibrate EP IMpurity A
  • Chloro-4'-hydroxybenzophe
  • -4'-two4-chlorinehydroxylbenzophenone
  • Fenofibrate Related Compound A (4-Chloro-4'-Hydroxybenzophenone)
  • 4-Chloro-4'-hydroxybenzophenone≥ 99% (GC)
  • 1-(4-Chlorophenyl)-1-(4-hydroxyphenyl)methanone
  • Benzophenone,4-chloro-4'-hydroxy- (6CI)
  • Choline Fenofibrate Impurity A
  • Fenofibrate impurity A (EP) -G
  • Fenofibrate impurity A (EP)
  • 4-Chloro-4'-hydroxybenzoph
  • Fenofibrate Impurity 1(Fenofibrate EP Impurity A)
  • 4-Chloro-4'-hydroxybenzophenone benzophenone
  • 4-Chloro-4'-
  • 4-Chloro-4'-hydroxybenzophenone&gt
  • Fenofibrate impurity A CRS
  • Fenofibrate Related Impurity A
  • Fenofibrate EP Impurity A/ Fenofibrate Related Compound A
  • Fenofibrate EP Impurity AQ: What is Fenofibrate EP Impurity A Q: What is the CAS Number of Fenofibrate EP Impurity A Q: What is the storage condition of Fenofibrate EP Impurity A Q: What are the applications of Fenofibrate EP Impurity A
  • Fenofibrate impurity A (F0048005)
  • Fenofibrate Impurity 2
  • Fenofibrate Related Compound A ((4-chlorophenyl)(4-hydroxyphenyl)methanone) (1269607)
  • NSC 4056
  • NSC4056
  • NSC-4056
  • Choline Fenofibrate EP Impurity A
  • Fenofibrate USP Related Compound A
  • 4-Chloro-4&#39
  • -hydroxybenzophenone
  • 5-Chloro-4’-hydroxybenzophenone
  • EP-A /USP RC A
  • 4-Chloro-4'-hydroxybenzophenone
  • 42019-78-3
  • 42019-78-2
  • 420-78-3
  • 42109-78-3
  • ClC6H4COC6H4OH