2,4-Dichloro-6-methylpyrimidine

Product Name: 2,4-Dichloro-6-methylpyrimidine
CAS No.: 5424-21-5
Chemical Name: 2,4-Dichloro-6-methylpyrimidine
Synonyms: 6-Methyl-2,4-dichloropyriMidine;2,6-DICHLORO-4-METHYLPYRIMIDINE;NSC 13199;AKOS BBS-00005839;4-Dichloro-6-MethylpyriMidine;2,4-DICHLORO-6-METHYLPYRIMIDE;2,4-dichloro-6-methyl-pyrimidin;2,4-DICHLORO-6-METHYLPYRIMIDINE;2,4-Dichloro-6-methyl-1,3-diazine;2,4-Dichloro-6-methylpyrimidine>
CBNumber: CB8443434
Molecular Formula: C5H4Cl2N2
Formula Weight: 163
MOL File: 5424-21-5.mol

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2,4-Dichloro-6-methylpyrimidine Property

Melting point:: 44-47 °C (lit.)
Boiling point:: 219 °C (lit.)
Density: 1.5462 (rough estimate)
refractive index: 1.6300 (estimate)
Flash point:: >230 °F
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
solubility: Chloroform (Very Slightly, Heated, Sonicated), DMSO (Sparingly, Heated)
form: powder to crystal
pka: -2.12±0.30(Predicted)
color: White to Orange to Green
Water Solubility: Soluble in Chloroform, Ether, Ethyl Acetate and Toluene. Insoluble in water.
BRN: 114295
InChI: InChI=1S/C5H4Cl2N2/c1-3-2-4(6)9-5(7)8-3/h2H,1H3
InChIKey: BTLKROSJMNFSQZ-UHFFFAOYSA-N
SMILES: C1(Cl)=NC(C)=CC(Cl)=N1
CAS DataBase Reference: 5424-21-5(CAS DataBase Reference)
EPA Substance Registry System: Pyrimidine, 2,4-dichloro-6-methyl- (5424-21-5)

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Safety

Hazard Codes: C
Risk Statements: 34
Safety Statements: 26-27-36/37/39-45
RIDADR: UN 3263 8/PG 2
WGK Germany: 3
Hazard Note: Corrosive
TSCA: T
HazardClass: 8
PackingGroup: III
HS Code: 29335990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H314Causes severe skin burns and eye damage

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P363Wash contaminated clothing before reuse.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 144185
Product name: 2,4-Dichloro-6-methylpyrimidine
Purity: 98%
Packaging: 25g
Price: $52.5
Updated: 2025/07/31

Sigma-Aldrich

Product number: 144185
Product name: 2,4-Dichloro-6-methylpyrimidine
Purity: 98%
Packaging: 100g
Price: $165
Updated: 2025/07/31

TCI Chemical

Product number: D2958
Product name: 2,4-Dichloro-6-methylpyrimidine
Purity: >98.0%(GC)
Packaging: 5g
Price: $38
Updated: 2025/07/31

TCI Chemical

Product number: D2958
Product name: 2,4-Dichloro-6-methylpyrimidine
Purity: >98.0%(GC)
Packaging: 25g
Price: $176
Updated: 2025/07/31

Usbiological

Product number: D3531-31
Product name: 2,4-Dichloro-6-methylpyrimidine|
Packaging: 20g
Price: $418
Updated: 2021/12/16

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2,4-Dichloro-6-methylpyrimidine Chemical Properties,Usage,Production

Chemical Properties

White to Light Yellow Powder

Uses

2,4-Dichloro-6-methylpyrimidine is used in the synthesis of (2-chloro-6-methyl-pyrimidin-4-yl)-(2,3-dihydro-benzothiazol-6-yl)-amine.

General Description

2,4-Dichloro-6-methylpyrimidine undergoes double cross-coupling reaction with 2-(tributylstannyl)pyridine, followed by aldol condensation to yield 4-arylvinyl-2,6-di(pyridin-2-yl)pyrimidines. It reacts with 1H,1H,2H,2H-perfluorodecanethiol during fluorous synthesis of disubstituted pyrimidines.

Synthesis

626-48-2

5424-21-5

Step 1. 2,4-Dichloro-6-methylpyrimidine (166-01) was prepared from 6-methylpyrimidine-2,4-diol (500 mg, 3.97 mmol) by reacting with phosphoryl chloride (4 mL) according to the literature procedure 49-01 to afford 540 mg of white solid product in 84% yield. Mass spectral analysis showed m/z: 164.7 [M + H]+.

References

[1] Bioorganic and Medicinal Chemistry Letters, 2003, vol. 13, # 10, p. 1755 - 1757
[2] Molecules, 2012, vol. 17, # 4, p. 4533 - 4544
[3] Patent: WO2018/14802, 2018, A1. Location in patent: Paragraph 0472; 0473
[4] Organic and Biomolecular Chemistry, 2003, vol. 1, # 19, p. 3353 - 3361
[5] Journal of Heterocyclic Chemistry, 1987, vol. 24, # 1, p. 205 - 209

2,4-Dichloro-6-methylpyrimidine Preparation Products And Raw materials

Raw materials

Preparation Products

2-AMINO-6-METHYL-PYRIMIDINE-4-THIOL 6-METHYL-2-(METHYLSULFANYL)PYRIMIDIN-4-YLAMINE 2-CHLORO-6-METHYLPYRIMIDIN-4-AMINE CRIMIDINE 4-AMINO-6-METHYLPYRIMIDINE-2-THIOL 2-Chloro-6-methylpyrimidin-4-ylamine

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2,4-Dichloro-6-methylpyrimidine Suppliers

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View Lastest Price from 2,4-Dichloro-6-methylpyrimidine manufacturers

Hebei Zhuanglai Chemical Trading Co Ltd

Product: 2,4-Dichloro-6-methylpyrimidine 5424-21-5
Price: US $100.00-50.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 20 tons
Release date: 2024-11-12

Career Henan Chemical Co

Product: 2,4-Dichloro-6-methylpyrimidine 5424-21-5
Price: US $3.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 200KG
Release date: 2020-01-07

5424-21-5, 2,4-Dichloro-6-methylpyrimidine Related Search:

2',4'-Dichloroacetophenone 1,2-Dichloro-4-(chloromethyl)benzene 2-Chloro-5-chloromethylpyridine Dichloromethylsilane 2,4-Dichloropyrimidine Pirimiphos-methyl Dichlorodimethylsilane Sulfamerazine 2,4-DICHLORO-5-NITROPYRIDINE 2,4-Dichloro-6-picoline 2,4-Dichloro-6-methyl-5-nitropyrimidine TERT-BUTYL 2,4-DICHLORO-7,8-DIHYDROPYRIDO[4,3-D]PYRIMIDINE-6(5H)-CARBOXYLATE (9H-FLUOREN-9-YL)METHYL 2,4-DICHLORO-5H-PYRROLO[3,4-D]PYRIMIDINE-6(7H)-CARBOXYLATE METHYL 2,4-DICHLOROPYRIMIDINE-6-CARBOXYLATE 2-(3-CHLOROPHENYL)MALONDIALDEHYDE (9H-FLUOREN-9-YL)METHYL 2,4-DICHLORO-7,8-DIHYDROPYRIDO[4,3-D]PYRIMIDINE-6(5H)-CARBOXYLATE 5-Bromo-2,4-dichloro-6-methylpyrimidine 2,4-Dichloro-5-methylpyrimidine ,98%,2,4-Dichloro-5-methylpyrimidine**Toxic, Stench**,2,4-DICHLORO-5-METHYLPYRIMIDINE

AKOS BBS-00005839

2,6-DICHLORO-4-METHYLPYRIMIDINE

2,4-DICHLORO-6-METHYLPYRIMIDINE

2,4-dichloro-6-methyl-pyrimidin

2,4-DICHLORO-6-METHYLPYRIMIDE

2,4-Dichloro-6-methylpyrimidine ,99%

2,4-Dichloro-6-methylpyrimidine,98%

4-Dichloro-6-MethylpyriMidine

6-Methyl-2,4-dichloropyriMidine

NSC 13199

2,4-Dichloro-6-methyl-1,3-diazine

2,4-Dichloro-6-methylpyrimidine&gt

Pyrimidine, 2,4-dichloro-6-methyl-

2,4-Dichloro-6-methylpyrimidine ISO 9001：2015 REACH

2,4-Dichloro-6-methylpyrimidine, 95%

5424-21-5

CH32CHCOCHCH32

HETERO CHLORIDE

Building Blocks

Pyrimidines

Heterocyclic Building Blocks

Halogenated Heterocycles

Heterocycle-Pyrimidine series

Building Blocks

C4 to C5

Chemical Synthesis

Halogenated Heterocycles

Heterocyclic Building Blocks

Bases & Related Reagents

Nucleotides

Building Blocks

Halogenated Heterocycles

Heterocyclic Building Blocks

PyrimidinesHeterocyclic Building Blocks

Heterocyclic Compounds

Nucleotides and Nucleosides

Pyrimidines

pharmacetical

Pyrimidine

Pyrimidine Series

Aromatic Carboxylic Acids, Amides, Anilides, Anhydrides & Salts

Pyridines, Pyrimidines, Purines and Pteredines