4-CHLORO-6-IODOQUINOLINE

Product Name: 4-CHLORO-6-IODOQUINOLINE
CAS No.: 40107-07-1
Chemical Name: 4-CHLORO-6-IODOQUINOLINE
Synonyms: BUTTPARK 89\01-03;4-CHLORO-6-IODOQUINOLINE;Quinoline, 4-chloro-6-iodo-
CBNumber: CB8446844
Molecular Formula: C9H5ClIN
Formula Weight: 289.5
MOL File: 40107-07-1.mol

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4-CHLORO-6-IODOQUINOLINE Property

Melting point:: 138-140℃
Boiling point:: 338℃
Density: 1.919
Flash point:: 158℃
storage temp.: under inert gas (nitrogen or Argon) at 2–8 °C
pka: 2.81±0.16(Predicted)
Appearance: Off-white to light yellow Solid
InChI: InChI=1S/C9H5ClIN/c10-8-3-4-12-9-2-1-6(11)5-7(8)9/h1-5H
InChIKey: XPXHGYKMODLJBY-UHFFFAOYSA-N
SMILES: N1C2C(=CC(I)=CC=2)C(Cl)=CC=1

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P310Immediately call a POISON CENTER or doctor/physician.

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N-Bromosuccinimide Price

Biosynth Carbosynth

Product number: FC57757
Product name: 4-Chloro-6-iodoquinoline
Packaging: 50mg
Price: $60
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FC57757
Product name: 4-Chloro-6-iodoquinoline
Packaging: 100mg
Price: $100
Updated: 2021/12/16

AK Scientific

Product number: 5329AB
Product name: 4-Chloro-6-iodoquinoline
Packaging: 250mg
Price: $147
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FC57757
Product name: 4-Chloro-6-iodoquinoline
Packaging: 250mg
Price: $200
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FC57757
Product name: 4-Chloro-6-iodoquinoline
Packaging: 500mg
Price: $300
Updated: 2021/12/16

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4-CHLORO-6-IODOQUINOLINE Chemical Properties,Usage,Production

Uses

4-Chloro-6-iodoquinoline is a commonly used synthetic intermediate in the fields of medicine and materials science, and can be used for cross-coupling reactions to synthesize different diarylquinoline compounds.

Synthesis

342617-07-6

40107-07-1

The general procedure for the synthesis of 4-chloro-6-iodoquinoline from 6-iodo-4-hydroxyquinoline was as follows: 6-iodo-4-hydroxyquinoline (100 g, 369 mmol) was suspended in phosphorus oxychloride (POCl3, 340 mL, 3.7 mol) at room temperature. After 1 hour of reaction, the reaction mixture was concentrated. The concentrated residue was carefully placed in an ice water bath and neutralized with saturated sodium bicarbonate solution. The resulting brown suspension was filtered and the solid was washed with water (2 x 500 mL) and subsequently dried under vacuum overnight to afford 4-chloro-6-iodoquinoline as a brown solid (103 g, 92% yield). The product was characterized by 1H NMR (400 MHz, DMSO-d6): δ 8.88 (d, J = 4.8 Hz, 1H), 8.54 (d, J = 1.8 Hz, 1H), 8.15 (dd, J = 8.8, 2.0 Hz, 1H), 7.88 (d, J = 8.8 Hz, 1H), 7.82 (d, J = 4.8 Hz, 1H); mass spectrum (MS) showed m/z of 289.9 ([M + H]+).

References

[1] Patent: US2012/41024, 2012, A1. Location in patent: Page/Page column 8; 10; 16
[2] Patent: EP2566477, 2015, B1. Location in patent: Paragraph 0157; 0160
[3] Journal of Medicinal Chemistry, 2016, vol. 59, # 10, p. 4867 - 4880
[4] Patent: WO2005/63739, 2005, A1. Location in patent: Page/Page column 64

4-CHLORO-6-IODOQUINOLINE Preparation Products And Raw materials

Raw materials

Preparation Products

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4-CHLORO-6-IODOQUINOLINE Suppliers

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View Lastest Price from 4-CHLORO-6-IODOQUINOLINE manufacturers

Career Henan Chemica Co

Product: 4-CHLORO-6-IODOQUINOLINE 40107-07-1
Price: US $1.00/g
Min. Order: 1g
Purity: 85.0-99.8%
Supply Ability: 20ton
Release date: 2020-10-28

40107-07-1, 4-CHLORO-6-IODOQUINOLINERelated Search:

2-CHLORO-6-IODO-QUINOLINE 2-CHLORO-3-IODOQUINOLINE 8-CHLORO-3-IODOQUINOLINE 6-Iodoquinoline 4-CHLORO-6-IODOQUINOLINE 7-CHLORO-4-IODOQUINOLINE 97,7-CHLORO-4-IODOQUINOLINE, PURUM, 97% ethyl 4-chloro-8-iodoquinoline-3-carboxylate 4-CHLORO-6-IODO-QUINOLINE-3-CARBOXYLIC ACID ETHYL ESTER 4-Chloro-5-iodoquinoline 4-CHLORO-8-IODOQUINOLINE 2-chloro-5-iodoquinoline 4-Chloro-7-iodoquinoline 4-CHLORO-3-IODOQUINOLINE 4-HYDROXY-7-CHLORO-3-IODOQUINOLINE Ethyl 4-chloro-8-iodoquinoline-3-carboxylate ,97% 4-chloro-8-iodoquinoline-3-carbonitrile 7-CHLORO-4-IODOQUINOLINE 8-BROMO-2-CHLORO-3-IODOQUINOLINE

4-CHLORO-6-IODOQUINOLINE

BUTTPARK 89\01-03

Quinoline, 4-chloro-6-iodo-

40107-07-1

CHIRAL CHEMICALS